DecreasedMacrophageNumberandActivationLeadtoReducedLymphaticVesselFormationandContributetoImpairedDiabeticWoundHealing
【摘要】Impairedwoundhealingisacommoncomplicationofdiabetes.Althoughitiswellknownthatbothmacrophagesandbloodvesselsarecriticaltowoundrepair,theroleofwound-associatedlymphaticvesselshasnotbeenwellinvestigated.Wereportthatboththepresenceofactivatedmacrophagesandtheformationoflymphaticvesselsarerat...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第4期SOCS-3negativelyregulatesinnateandadaptiveimmunemechanismsinacuteIL-1–dependentinflammatoryarthritis
...atoryimmunemechanisms.TheSOCSproteinsarenegativeregulatorsofcytokinesignaling,buttodatetherehasbeenlittleinformationontheirfunctionindisease.ThegenerationofSocs3–/vavmice,whichlackSOCS-3inthehematopoieticandendothelialcellcompartment,allowedustoexploretheroleofendogenousSOCS-3duringacuteinflammato...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期前列腺素E1的临床应用
...压患者,在入院后给予常规综合治疗,每日PGE1100~200μg,以15ng/(kg·min)起,每日追加5ng/(kg·min),共4天,至30ng/(kg·min)为止,均用生理盐水输注,并进行血压、心率及Swan-Ganz导管血液动力学、心输出量监测。结果显示PGE1具明显降低肺循环阻...
医源资料库;在线期刊;中华中西医杂志;2005年第6卷第19期MaintenanceofBadPhosphorylationPreventsApoptosisofRatHepaticSinusoidalEndothelialCellsinVitroandinVivo
...ialcells(SECs),weexaminedthephosphorylationstatusofBadanditsupstreamsignalingmoleculesduringapoptosisincultureandafterischemia-reperfusioninjury.RatSECswereisolatedbytheimmunomagneticmethod,and2daysafterculture,mostSECsunderwentapoptosis,whichwasassociatedwithdecreasedtyrosinephosphorylationofcellul...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期N-TerminalProteolysisoftheEndothelinBReceptorAbolishesItsAbilitytoInduceEGFReceptorTransactivationandContractileProteinExpressioninVascula
...lcleavageinvascularsmoothmusclecells(VSMCs).MethodsandResults-VSMCsexpressingeitherthefull-lengthETBreceptororanN-terminallytruncatedETBreceptor(correspondingtotheN-terminallycleavedreceptor)wereanalyzedforligand-inducedmitogen-activatedproteinkinaseactivationandexpressionofcontractileproteins.InVSM...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第6期c-Fosproteinasatargetofanti-osteoclastogenicactionofvitaminD,andsynthesisofnewanalogs
...wthevitaminDreceptor(VDR)regulatesbonecellfunctionremainslargelyunknown.Usingosteoprotegerin-deficientmice,whichexhibitsevereosteoporosisduetoexcessivereceptoractivatorofNF-Bligand/receptoractivatorofNF-B(RANKL/RANK)stimulation,weshowhereinthatoraltreatmentofthesemicewith1,25-dihydroxyvitaminD3inhib...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第2期19.9高碘甲状腺肿的发病机理
...,碘过多地占据了过氧化酶原来用于催化酪氨的活性基,因而使更我的I-氧化I0,但此时缺乏活性的酪氨酸与之结全,因而I0与I0结合氧化成为I2释出,因而MIT及DIT的生成而减少。从而使血清T3及T4的生成减少,可使患者发生甲低底...
医源资料库;医源图书馆;教材类;临床营养学Hyperactivationofp21rasandPI3Kcooperatetoaltermurineandhumanneurofibromatosistype1–haploinsufficientosteoclastfunctions
...ofMedicine,Indianapolis,Indiana,USA.Addresscorrespondenceto:D.WadeClapporFeng-ChunYang,IndianaUniversitySchoolofMedicine,HermanB.WellsCenterforPediatricResearch,CancerResearchInstitute,1044WestWalnutStreet,R4402,Indianapolis,Indiana46202,USA.Phone:(317)278-9290;Fax:(317)274-8679;E-mail:dclapp@iupui....
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期肿瘤坏死因子α和干扰素γ对癌性贫血患者红细胞生成素生成和红系增生的影响
...性贫血患者血清TNF-α、IFN-γ水平分别为(25.75±26.71)ng/L、(50.49±42.12)ng/L,均显著高于正常对照组及癌症无贫血组。TNF-α、IFN-γ水平与血红蛋白浓度之间呈负相关关系。TNF-α与O/PEPO、O/PsTfR之间呈负相关。血清IFN-γ...
行业资讯;临床快报;肿瘤相关新生儿先天性肺囊肿合并肺透明膜病1例
...键词】新生儿;先天性肺囊肿;肺透明膜病 1病历摘要0.5ng/ml,<2ng/ml,CRP正常,血培养(-),血气:pH7.257,PaCO27.39kPa,PO212.59kPa,FiO221%,胸片如图1。结合患儿临床特点,“新生儿肺透明膜病诊断成立,给予气管插管内注入固尔苏120...
医源资料库;在线期刊;中华现代儿科学杂志;2010年第7卷第2期