ReductionofAmyloidAngiopathyandAßPlaqueBurdenafterEnrichedHousinginTgCRNDMice
【摘要】DiversityandintensityofintellectualandphysicalactivitiesseemtohaveaninverserelationshipwiththeextentofcognitivedeclineinAlzheimer??sdisease(AD).TostudytheinteractionbetweenanactivelifestyleandADpathology,femaleTgCRND8micecarryinghumanAPPswe+indweretransferredintoenrichedhousing.Fourmonth...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期EpidermalGrowthFactorReceptorIsaCriticalMediatorofUltravioletBIrradiation-InducedSignalTransductioninImmortalizedHumanKeratinocyteHaCaTCell
【摘要】Epidermalgrowthfactorreceptor(EGFR)isacriticalmediatorofseveraltypesofepithelialcancers.SkincancerarisingfromexposuretoultravioletBirradiation(UVB)fromthesunisaprominentformofhumancancer.Recentdataindicatethatinadditiontocognateligands,EGFRisactivatedbyUVBirradiation.Weusedpharmacologica...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期Antisenseoligonucleotidetherapyforneurodegenerativedisease
1LudwigInstituteforCancerResearch,UniversityofCalifornia,SanDiego,LaJolla,California,USA.2TheScrippsResearchInstitute,LaJolla,California,USA.3CenterforNeurologicStudy,LaJolla,California,USA.4DepartmentofNeurosciences,UniversityofCalifornia,SanDiego,LaJolla,California,USA.5IsisPharmaceuticals,Carlsba...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第8期TranscriptionalActivationofHepaticACSL3andACSL5byOncostatinMReducesHypertriglyceridemiaThroughEnhancedβ-Oxidation
【摘要】Objective—InourpreviousstudiesthatexaminedinvivoactivitiesofoncostatinM(OM)inupregulationofhepaticLDLreceptor(LDLR)expression,weobservedreductionsofLDL-cholesterolandtriglyceride(TG)levelsinOM-treatedhyperlipidemichamsters.Interestingly,theOMeffectofloweringplasmaTGwasmorepronounce...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第10期Toll-LikeReceptors2-DeficientMiceAreProtectedAgainstPostischemicCoronaryEndothelialDysfunction
【摘要】Objectives-Toll-likereceptors(TLR)2areexpressedincardiacandinflammatorycells,andregulateleukocytefunction.Becauseleukocyteadhesionisacriticaleventinendothelialinjuryinducedbyischemia/reperfusion(I/R),weassessedwhetherTLR2wereinvolvedinI/R-inducedcoronaryendothelialinjury.MethodsandResult...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第5期InVivoandInVitroStudiesofaNovelCytokine,Interleukin42,inPulmonaryTuberculosis
CentreforInfectiousDiseasesandInternationalHealth,RoyalFreeandUniversityCollegeMedicalSchoolDepartmentsofThoracicandHIVMedicineandRadiology,RoyalFreeHospitalNHSTrust,London,UnitedKingdomABSTRACTRationale:TuberculosisprogressesdespitepotentTh1responses.Aputativeexplanationisthesimultaneouspresenceofa...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第8期LithiumtreatmentinhibitsrenalGSK-3activityandpromotescyclooxygenase2-dependentpolyuria
...althServiceResearch,VanderbiltUniversityMedicalCenter,andVeteransAdministrationMedicalCenter,Nashville,TennesseeABSTRACTTheuseofLiClinclinicalpsychiatryisroutinelycomplicatedbyovertnephrogenicdiabetesinsipidus(NDI),themechanismofwhichisincompletelyunderstood.Invitrostudiesindicatethatlithiumcaninduc...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第4期AbnormalEGF-dependentregulationofsodiumabsorptioninARPKDcollectingductcells
...mentofPediatricsandPhysiologyandBiophysics,RainbowCenterforChildhoodPolycysticKidneyDisease,CaseWesternReserveUniversity,Cleveland,OhioABSTRACTAmiloride-sensitivesodiumentry,viatheepithelialsodiumchannel(ENaC),istherate-limitingstepforNa+absorptioninkidneycollectingducts,andepidermalgrowthfactor(EGF...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第3期p47phoxAssociatesWiththeCytoskeletonThroughCortactininHumanVascularSmoothMuscleCells
FromMultidisciplinaryResearchGrouponHypertension(R.M.T.,G.Y.,E.L.S.),ClinicalResearchInstituteofMontreal,UniversityofMontreal,Canada;DepartmentofVeterinaryMolecularBiology(M.T.Q.),MontanaStateUniversity,Bozeman;HypertensionandVascularResearchDivisionandBiostatisticsDepartment(P.J.P.),HenryFordHospit...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第3期StatinsDecreaseToll-LikeReceptor4ExpressionandDownstreamSignalinginHumanCD14+Monocytes
...ethe,MD,Harvard–MITDivisionofHealthSciencesandTechnology,MassachusettsInstituteofTechnology,77MassachusettsAvenue,Building56-322,Cambridge,MA02139.E-mailhmethe@mit.eduAbstractObjective—Anti-inflammatoryeffectsofstatinscontributetotheirclinicalbenefit.Molecularmechanismsunderlyingtheseeffectshave...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第7期