LeukocyteTransglutaminase2ExpressionLimitsAtheroscleroticLesionSize
【摘要】Objective-Transglutaminase2(TG2),abroadlyexpressedregulatorofproteincross-linking,woundhealing,andtissuefibrosis,mediatesapoptoticcellingestionandtransforminggrowthfactor-ßreleasebymacrophagesandtherebycanlimitleukocyte-mediatedinflammation.Inatherosclerosis,oxidativestressandaccum...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第3期CellularTopoisomeraseIInhibitionandAntiproliferativeActivitybyMJ-III-65(NSC706744),anIndenoisoquinolineTopoisomeraseIPoison
...utesofHealth,Bethesda,Maryland(S.A.,G.K.,K.A.,Y.P.)DepartmentofMedicinalChemistryandMolecularPharmacology,PurdueUniversity,WestLafayette,Indiana(M.J.,M.C.)GraceCancerDrugCenter,RoswellParkCancerInstitute,Buffalo,NewYork(S.C.,F.D.,Y.M.R.)AbstractToovercomecamptothecin‘s(CPT)lactoneinstability,rever...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第2期细胞培养技术
...标志细胞已进入指数增生期。 2.指数增生期(LogarithmicgrowthPhase): 这是细胞增值最旺盛的阶段,细胞分裂相增多。指数增生期细胞分裂相数量可作为判定细胞生长旺盛与否的一个重要标志。一般以细胞分裂(MitoticIndex...
医药经济;生物技术;实验技术;细胞学技术Cross-ResistancetoDeathLigand-InducedApoptosisinCisplatin-SelectedHeLaCellsAssociatedwithOverexpressionofDDB2andSubsequentInductionofcFLIP
TumorBiologyLaboratory,DepartmentofBiochemistry,ChangGungUniversity,Taoyuan,Taiwan,RepublicofChinaAbstractThisworkreportstheinvolvementofdamagedDNA-bindingprotein2(DDB2),acomponentinvolvedinthegenomicrepairofUVdamage,inthecross-resistanceofcisplatin-selectedcelllinestodeathligand-mediatedapoptosis.T...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第4期Adiposedifferentiation-relatedproteinandregulatorsoflipidhomeostasisidentifiedbygeneexpressionprofilinginthemurinedb/dbdiabetickidney
...】Weinvestigatedthemolecularbasisofprogressivediabeticrenalinjuryindb/dbmicebyprofilingkidneygeneexpression.Usinghigh-densitymicroarrays,weidentified482RNAtranscriptsdifferentiallyexpressedin8-wkdb/dbvs.nondiabeticdb/mkidneys,atimecharacterizedbyhyperglycemiabutbylittlerenalhistopathology.By16wksig...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第5期4-Hydroxy-2-NonenalIncreasesSuperoxideAnionRadicalinEndothelialCellsviaStimulatedGTPCyclohydrolaseProteasomalDegradation
...xidativestressinendotheliumbymechanismsthatremaincontroversial.Thisstudyexaminestheeffectsof4-HNEonnitricoxide(NO)andsuperoxidelevelsinbovineaortaendothelialcells(BAECs).MethodsandResults—ExposureofBAECsto4-HNEcausedadose-dependentinhibitionofNOthatcorrelatedwithlossesofhsp90andphosphorylatede...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第11期BindingSiteofaNovelKv1.5Blocker:A“FootintheDoor“againstAtrialFibrillation
...erewecharacterizethemechanismsofactionof2‘-{[2-(4-methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylicacid(2-pyridin-3-yl-ethyl)-amide(AVE0118)onKv1.5channelsheterologouslyexpressedinXenopuslaevisoocytes.Wholecellcurrentsinoocyteswererecordedusingthetwo-microelectrodevoltageclamptechnique.AV...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期ResiduesMet89andSer160intheHumanEquilibrativeNucleosideTransporter1AffectItsAffinityforAdenosine,Guanosine,S6-(4-Nitrobenzyl)-mercaptopurine
...NT1)isanimportantmodulatorofthephysiologicalactionofadenosine.Weidentifiedaminoacidresiduesinvolvedinadenosinetransportusingayeast-basedassaytorapidlyscreenandidentifyrandomlygeneratedhENT1mutantsthatexhibiteddecreasedsensitivitytoinhibitionofadenosinetransportbyvarioushENT1competitiveinhibitors.Wei...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第3期EarlyVirologicNonresponsetoTenofovir,Abacavir,andLamivudineinHIV-InfectedAntiretroviral-NaiveSubjects
...eases,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,MarylandUniversityofMiami,Miami,FloridaKaiserPermanente,Atlanta,GeorgiaRoseMedicalCenter,Denver,ColoradoNorthstarMedicalCenter,Chicago,IllinoisGlaxoSmithKline,ResearchTrianglePark,NorthCarolinaBackground.Antiretroviralcombinationsthatreducethenu...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第23期Aminoacidlossesduringhemodialysiswithpolyacrylonitrilemembranes:effectofintradialyticaminoacidsupplementationonplasmaaminoacidconcentrations
...AntonioRiveroandJavierGarcía1FromtheDepartmentsofNephrologyandBiochemistryandtheResearchUnit,HospitalNuestraSeñoradeCandelaria,SantaCruzdeTenerife,Tenerife,Spain,andtheResearchUnit,HospitalRamónyCajal,Madrid.2Supportedbygrant96/0370fromFondodeInvestigacionesSanitarias,Ministerio...
医源资料库;在线期刊;美国临床营养学杂志;2000年71卷第3期