InductionofNeutrophilGelatinase-AssociatedLipocalininVascularInjuryviaActivationofNuclearFactor-B
...eintimaafterangioplastybutwasattenuatedbyadenovirus-mediatedexpressionofadominant-negativemutantofinhibitorofnuclearfactor(NF)-Bkinaseß(dnIKKß).ExpressionofNGALmRNAandproteinwasalsoup-regulatedinanNF-B-dependentmannerinratandhumanvascularsmoothmusclecells(SMCs)inresponsetointerleukin-1&s...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期DetectionofMutationsAssociatedwithIsoniazidResistanceinMycobacteriumtuberculosisIsolatesfromChina
...esistantisolateshadmutationsinthekatGgene,withthekatGSer315Thrmutationpredominant(55.2%).Nomutationatcodon463ofkatGwasdetectedamongthe50INH-susceptibleisolateswithdifferentIS6110fingerprints.Inaddition,therewere35(40.2%)INH-resistantisolatesthathadamutationatcodon463ofkatG.OftheINH-resistantstrains,...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第11期TherapeuticAngiogenesisUsingNovelVascularEndothelialGrowthFactor-E/HumanPlacentalGrowthFactorChimeraGenes
...F-E,foundinthegenomeoftheOrfvirus,specificallybindstoVEGFreceptor-2andshowsmitoticactivityonendothelialcells.Recently,wecreatedtwoformsofVEGF-Eandhumanplacentalgrowthfactor(PlGF)chimeragenes(VEGF-Echimera#9andVEGF-Echimera#33),whicharehumanizedgeneswithVEGF-Efunctionbutshowinglessantigenicity.Method...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第1期LysinerequirementsofchronicallyundernourishedadultIndianmen,measuredbya24-hindicatoraminoacidoxidationandbalancetechnique
...ofPhysiologyandDivisionofNutrition(AVK,TR,JV,andRK)andtheDepartmentofBiochemistry(JG),StJohnsMedicalCollege,BangaloreIndia,andtheLaboratoryofHumanNutrition,MassachusettsInstituteofTechnology,Cambridge(MMRandVRY).2SupportedbyNIHgrantsRR88,DK42101,andP30-DK40561.3AddressreprintrequeststoAVKurpad...
医源资料库;在线期刊;美国临床营养学杂志;2003年77卷第1期InducibleDNAbreaksinIgSregionsaredependentonAIDandUNG
DepartmentofMolecularGeneticsandMicrobiology,PrograminImmunologyandVirology,UniversityofMassachusettsMedicalSchool,Worcester,MA01655Classswitchrecombination(CSR)occursbyanintrachromosomaldeletionwherebytheIgMconstantregiongene(Cμ)isreplacedbyadownstreamconstantregiongene.Thisuniquerecombinationeven...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第4期ThePositionalInfluenceoftheHelicalGeometryoftheHeteroduplexSubstrateonHumanRNaseH1Catalysis
...tes.Enhancedcleavagerateswereobservedfortheeastern-biased2‘-ara-fluorothymidineandbulgeinducingN-methylthymidinemodificationspositionedatthe5‘-DNA/3‘-MOEjunctionaswellasthesouthern-biased2‘-methylthiothymidineandconformationallyflexibletetrafluoroindole(TFI)modificationspositionedatthe5‘-M...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期SecretedProteinAcidicandRichinCysteineDeficiencyAmelioratesRenalInflammationandFibrosisinAngiotensinHypertension
...modeling.SPARChasbeenshowntoregulatetheexpressionofcollagentypeIandtransforminggrowthfactor-ß1inmesangialcellsandtobehighlyexpressedduringtubulointerstitialfibrosisinratangiotensin(ANG)IIinfusionmodels.WehypothesizedthatSPARCisadownstreameffectorofANGIIandthatlossofhostSPARCfunctionprovidesapr...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第10期InsulinFacilitatestheHepaticClearanceofPlasmaAmyloidβ-Peptide(1–40)byIntracellularTranslocationofLow-DensityLipoproteinReceptor-RelatedProtei
...estedtoplayaroleinpreventingAβ(1–40)accumulationinthebrain.EpidemiologicalinvestigationssuggestahighincidenceofcerebralAβdepositionininsulin-resistanttypeIIdiabetesmellitus.ThepurposeofthisstudywastoclarifytheeffectofinsulinonthehepaticclearanceofAβ(1–40).LRP-1expressionon...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期DC-SIGNIstheMajorMycobacteriumtuberculosisReceptoronHumanDendriticCells
:1INSERMEMI-0013InstitutUniversitaired‘Hématologie,AssistancePublique-HôpitauxdeParis2ServicedeMicrobiologie,AssistancePublique-HôpitauxdeParis3INSERMERM-0220,InstitutUniversitaired‘Hématologie,HôpitalSaint-Louis,75010Paris,France4GroupeVirusetImmunité,InstitutPasteur,7501...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第1期TransgenicOverexpressionofLocallyActingInsulin-LikeGrowthFactor-1InhibitsUbiquitin-MediatedMuscleAtrophyinChronicLeft-VentricularDysfunction
...hronicleft-ventriculardysfunction.Skeletalmuscleatrophydevelopedinwild-typemice12weeksfollowingmyocardialinfarctionaccompaniedbyanincreaseintotalproteinubiquitinationandenhancedproteasomeactivity,activationofFoxotranscriptionfactors,androbustinductionoftheubiquitin-proteinligaseatrogin-1/MAFbx.Furth...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第9期