IdentificationoftheAtypicalL-TypeCa2+ChannelBlockerDiltiazemandItsMetabolitesAsGhrelinReceptorAgonists
【关键词】Identificationdiltiazem,whereasM4andM6metabolitesdisplayedweakagonistactivity,andtheM8andM9metaboliteswereinactive.BindingaffinitiesofdiltiazemandthesemetabolitestoGHSR1areceptorsfollowedasimilarrankorder.InvivotestsshowedthatdiltiazemandM2eachstimulatedgrowthhormonereleaseinmaleSprag...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期InsulinFacilitatestheHepaticClearanceofPlasmaAmyloidβ-Peptide(1–40)byIntracellularTranslocationofLow-DensityLipoproteinReceptor-RelatedProtei
【关键词】β-peptide(1–40)Thehepaticclearanceofamyloidβ-peptide(1–40)[Aβ(1–40)]fromplasma,whichislargelymediatedbylow-densitylipoproteinreceptor-relatedprotein(LRP-1),issuggestedtoplayaroleinpreventingAβ(1–40)accumulationinthebrain.Epidemiologicalinvestigation...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期ReceptortyrosinekinasesmediateepithelialNa+channelinhibitionbyepidermalgrowthfactor
...nter,SanAntonio,TexasABSTRACTEpidermalgrowthfactor(EGF)decreasesNa+reabsorptionacrossdistalnephronepithelia.ActivityoftheepithelialNa+channel(ENaC)islimitingforNa+transportinthisportionofthenephron.AbnormalENaCactivityandEGFsignalingarebothassociatedwithpolycystickidneydiseaselocalizedtothedistalnep...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第1期HostcontrolofMycobacteriumtuberculosisisregulatedby5-lipoxygenase–dependentlipoxinproduction
1ImmunobiologySection,LaboratoryofParasiticDiseases,NationalInstituteofAllergyandInfectiousDiseases(NIAID),NIH,Bethesda,Maryland,USA.2LaboratoriodeImunorregulacaoeMicrobiologia,CentrodePesquisasGoncaloMoniz,Funda??oOswaldoCruz,Salvador,Bahia,Brazil.3CenterforExperimentalTherapeuticsandReperfusionInj...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期LeukotrieneModifierTherapyforMildSleep-disorderedBreathinginChildren
KosairChildren‘sHospitalResearchInstitute,DepartmentofPediatricsDivisionofEar,NoseThroat,DepartmentofSurgeryDepartmentofPharmacologyandToxicology,UniversityofLouisville,Louisville,KentuckyABSTRACTBackground:Childrenwithmildsleep-disorderedbreathing(SDB),whomaynotberecommendedforadenotonsillectomy,...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第8期ElevatedPlasmaMembraneCholesterolContentAltersMacrophageSignalingandFunction
【摘要】Objective-Duringatherogenesis,macrophagesmigrateintothesubendothelialspacewheretheyingestdepositedlipoproteins,accumulatelipids,andtransformintofoamcells.Itisunclearwhythesemacrophagesdonotremovetheirlipidloadsfromtheregion.Thisstudywasaimedattestingthehypothesisthatmacrophagebehaviorisa...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第2期Cholesterol-loweringeffectofß-glucanfromoatbraninmildlyhypercholesterolemicsubjectsmaydecreasewhenß-glucanisincorporatedintobread
...raandRonaldPMensink1FromtheDepartmentofHumanBiology(DAJMKandRPM)andtheNutritionandToxicologyResearchInstituteMaastricht(DAJMK,GH,andRPM),MaastrichtUniversity,Maastricht,Netherlands.2SupportedbytheRaisioGroupLtd,Raisio,Finland.3Reprintsnotavailable.AddresscorrespondencetoRPMensink,DepartmentofHumanBi...
医源资料库;在线期刊;美国临床营养学杂志;2003年78卷第2期EvidenceinFavorofaCalcium-SensingReceptorinArterialEndothelialCells
....E.)andFacultyofMedicalandHealthSciences(J.O.),UniversityofManchester,UKInstitutdeChimiedesSubstancesNaturelles(R.H.D.,P.D.),UPR2301,CNRS,Gif-sur-Yvette,FranceSignalTransductionandDevelopmentalNeuropharmacology(M.R.,C.P.),UPR9040andIFR2118,CNRS,Gif-sur-Yvette,France.AbstractSmallincreasesinextracell...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第8期VacuolarLeukoencephalopathywithWidespreadAstrogliosisinMiceLackingTranscriptionFactorNrf
【摘要】NFE2-relatedfactor2(Nrf2),anoxidant-activatedCNCbZiptranscriptionfactor,hasbeenimplicatedindefenseagainstoxidativestressandchemicalinsultsinarangeofcellandtissuetypes,includingthecentralnervoussystem.Here,wereportthatdeletionoftheNrf2geneinmicecausedvacuolar(spongiform)leukoencephalopath...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第6期MultilocusSequenceTypingofIntercontinentalBovineStaphylococcusaureusIsolates
...ine,WashingtonStateUniversity,Pullman,Washington99164-6610QualityMilkProductionServices,22ThornwoodDrive,Ithaca,NewYork14850MicrobiologyDepartment,FacultyofSciences,AustralUniversityofChile,P.O.Box167,Valdivia,ChileDivisionofFoodAnimalScience,SchoolofVeterinaryScience,UniversityofBristol,LangfordHou...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期