ExpressionofAngiopoietin-2inEndothelialCellsIsControlledbyPositiveandNegativeRegulatoryPromoterElements
...giogenesisResearch,TumorBiologyCenter,D-79106Freiburg,Germany.ABSTRACTObjective—Angiopoietin-2(Ang-2)isanon-signaltransducingligandoftheendothelialreceptortyrosinekinaseTie-2.Ang-2isproducedbyendothelialcellsandactsasanautocrineregulatormediatingvasculardestabilizationbyinhibitingAngiopoietin-1-me...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第10期Antihypertensivetherapyinducescompartment-specificchemokineexpressionandaTh1immuneresponseintheclippedkidneyofGoldblatthypertensiverats
【摘要】Thepresentstudyexaminedthepathogenesisofinterstitialinflammationandfibrosisinantihypertensivelytreatedratswithtwo-kidney,one-cliphypertension.Hypertensiveratswererandomizedintofourgroups:notreatmentandmoderate,intermediate,andintensifiedloweringofbloodpressurewithincreasingdosesofavasope...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期Transforminggrowthfactor-inacuterenalfailure:receptorexpression,effectsonproliferation,cellularity,andvascularizationafterrecoveryfrominjury
...(TGF)-1andanumberofTGF--responsivegenesaretransientlyenhancedfollowinginductionofischemicacuterenalfailure(ARF)intherat.ThemRNAandproteinexpressionofTGF-receptorswereanalyzedinpostischemicratkidneysbyribonucleaseprotection,insituhybridization,andimmunohistochemistry.TGF-RIand-RIIwereenhancedwithin3d...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第3期ReductionofAtheroscleroticPlaquesbyLysosomalAcidLipaseSupplementation
FromtheDivisionandPrograminHumanGenetics(H.D.,G.A.G.)andDivisionofPathologyandLaboratoryMedicine(D.P.W.),Children’sHospitalResearchFoundation,Cincinnati,OH,45229;andGenzymeCorporation(S.S.,N.W.,M.L.),Cambridge,MA.CorrespondencetoGregoryA.Grabowski,MD,ProfessorandDirector,DivisionandPrograminHumanG...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第1期InductionofNeutrophilGelatinase-AssociatedLipocalininVascularInjuryviaActivationofNuclearFactor-B
【摘要】Neutrophilgelatinase-associatedlipocalin(NGAL)hasrecentlyemergedasanimportantmodulatorofcellhomeostasis.ElevatedplasmaNGALlevels,possiblybecauseofactivationofbloodleukocytes,areassociatedwithatherosclerosis.However,littleisknownaboutinductionofNGALexpressioninbloodvessels.Usingaratcaroti...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期Alcoholconsumptionandriskoflungcancer:apooledanalysisofcohortstudies
...rmoVirtamo,WalterCWillettandDavidJHunter1FromtheDepartmentofSocialandPreventiveMedicine,UniversityatBuffalo,StateUniversityofNewYork,Buffalo,NY(JLF);theDepartmentsofBiostatistics(JR),Nutrition(SAS-W,ER,WCW,andDJH),andEpidemiology(SAS-W,GC,ER,WCW,andDJH),HarvardSchoolofPublicHealth,Boston,MA;theCance...
医源资料库;在线期刊;美国临床营养学杂志;2005年82卷第3期AngiotensinII,reactiveoxygenspecies,andCa2+signalinginafferentarterioles
...ology,UniversityofNorthCarolinaatChapelHill,ChapelHill,NorthCarolinaABSTRACTInafferentarteriolarvascularsmoothmusclecells,ANGIIinducesariseincytosolicCa2+([Ca2+]i)viainositoltrisphosphatereceptor(IP3R)stimulationandbyactivationoftheadeninediphosphateribose(ADPR)cyclasetoformcyclicADPR,whichsensitize...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第11期TheherpesviralFcreceptorfcr-1down-regulatestheNKG2DligandsMULT-1andH60
...istologyandEmbryology,FacultyofMedicine,UniversityofRijeka,51000Rijeka,Croatia2InstituteforVirology,Heinrich-Heine-UniversityDüsseldorf,40225Düsseldorf,Germany3InstituteforVirology,HannoverMedicalSchool,30625Hannover,Germany4MaxvonPettenkoferInstitute,LudwigMaximiliansUniversityofMunich,80336Munic...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期LipidPeroxidationInhibitionBluntsNuclearFactor-BActivationReducesSkeletalMuscleDegenerationandEnhancesMuscleFunctioninmdxMice
【摘要】Duchennemusculardystrophy(DMD)isaprogressivemuscle-wastingdiseaseresultingfromlackofthesarcolemmalproteindystrophin.However,themechanismleadingtothefinaldiseasestatusisnotfullyunderstood.Severallinesofevidencesuggestarolefornuclearfactor(NF)-BinmuscledegenerationaswellasregenerationinDMD...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第3期StimulationofLiver-DirectedCholesterolFluxinMicebyNovelN-Acetylgalactosamine-TerminatedGlycolipidsWithHighAffinityfortheAsialoglycoproteinRec
【摘要】Objective-Interventionsthatpromoteliver-directedcholesterolfluxcansuppressatherosclerosis,asdemonstratedforscavengerreceptor-BIoverexpressioninhypercholesterolemicmice.Inanalogy,wespeculatethatincreasinglipoproteinfluxtotheliverviatheasialoglycoproteinreceptor(ASGPr)maybeoftherapeuticval...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第1期