Sleep-disorderedBreathinginNewbornMiceHeterozygousfortheTranscriptionFactorPhox2b

...esults:Wefoundthatsleepapneatotaltimewasapproximatelysixtimeslonger(8.9±12vs.1.5±2.2seconds,p0.0015),andventilationduringactivesleepwas21%lower(18.4±5.1vs.23.3±5.5ml/g/second,p0.006)inmutantthaninwild-typepups.Duringwakefulness,apneatimeandventilationwerenotsignificantlydifferentbetweenmutantand...

自然人VS基因修饰人？

“WADA的使命就是做一个干净的公平的运动会，如果使用基因兴奋剂，显然是不公平的。”国家反兴奋剂中心吴侔天教授说。　对这一话题，WADA给出了三个标准：医学或其他科学证据、药理学作用或经验证明，该种物质或方法可...

生物燃料vs道德风险，孰轻孰重？

道德风险是上世纪80年代西方经济学家提出的一个经济哲学范畴的概念，即“从事经济活动的人在最大限度地增进自身效用的同时做出不利于他人的行动。”或者说是：从事经济活动者一方不完全承担风险后果时所采取的自身效...

DifferentialexpressionofnuclearAT1receptorsandangiotensinIIwithinthekidneyofthemalecongenicmRen2.Lewisrat

...hypertensivecomparedwiththeLewiscontrols(systolicbloodpressure:195±2vs.107±2mmHg,P0.01).AlthoughplasmaANGIIlevelswerenotdifferentbetweenstrains,circulatinglevelsofANG-(1-7)were270%higherandANGIconcentrationswere40%lowerinthemRen2.Lewisrats.Incontrast,bothcortical(CORT)andmedullary(MED)...

Acuteincreasesofrenalmedullaryosmolalitystimulateendothelinreleasefromthekidney

...pendentmanner(Pg*t).NS,notstatisticallysignificant.Posthoccontrasts:*P<0.05vs.baselineforsamegroup;P<0.05vs.284mosmol/kgH2Ogroupatspecifiedtimepoint;P<0.05vs.0-to30-mintimepointinsamegroup;P<0.05vs.921mosmol/kgH2Ogroup.TherewerenosignificantdifferencesinbaselineurinefloworNa+excretionratebetweenthet...

UrineconcentratingdefectinprostaglandinEP1-deficientmice

...eurineosmolalitywasobservedfortheEP1-/-mice(WT,2,166±153mosmol/kgH2Ovs.EP1-/-,1,954±139mosmol/kgH2O,P=0.3),itwasnotstatisticallysignificant.Toassessthenear-maximalurineconcentratingabilityofEP1-/-mice,healthylittermateswerewaterdeprived(WD)for24h.AsshowninFig.2A,urineosmolalityrosesign...

糖尿病大鼠膀胱收缩功能改变与M3受体关系的实验研究

...大鼠膀胱逼尿肌收缩力高于正常对照组，为（16.94±3.39）VS（11.46±2.59）cmH2O／100mg组织（P=0.04，n＝8），在1mmol/LCarbachol作用后糖尿病组大鼠膀胱逼尿肌收缩力显著高于正常对照组，为（31.96±4.42）VS（14.15±3.34）cmH2O／100mg组织（P0.0...

Effectsofisoprostaneontubuloglomerularfeedback:rolesofTPreceptors,NOS,andsaltintake

...rginine(L-NMA),theeffectof8-IsoonTGFwasenhancedinNSandHSbutnotinLS(LS:22±6vs.LS+L-NMA:28±6%,ns;NS:18±4vs.NS+L-NMA:40±4,P<0.01;HS:27±3vs.HS+L-NMA:65±6,P<0.01).However,U-46,619didnotfurtherincreaseTGFafterL-NMAinallsaltgroups(LS:43±7vs.LS+L-NMA:51±6,ns;NS:52±7vs.NS+L-NMA:48±8,ns;HS:114±21vs...

肝外门静脉梗阻患者的肝功能障碍.

...4例无腹水（第II组）。第I组与第II组患者的血清ALT（54±24vs.34±10IU/l，P<0.01）、白蛋白（3.2±0.3vs.3.7±0.4g/dl，P<0.01）、凝血酶原时间差异（9.0±4.5vs.2.4±1.9s，P<0.05）显著不同。与第II组患者相比，第I组患者的年龄大4岁、门脉高压病...

血浆HIVRNA的减少能增加肌肉氨基酸的合成代谢

...合成速度及血浆RaGln。结果发现：治疗后，中位CD4增加(98vs.139cells/µl,P=0.009)而中位HIVRNA减少(155,828vs.100copies/ml,P=0.003)。肌肉蛋白质合成速度增加(0.062±0.005vs.0.078±0.006%/h,P=0.01),RaGln减慢(387±33vs.323±15µmol•kgfat-freemass–1R...