第四节 糖代谢的先天性异常
...效循环得不到控制,造成ATP大量分解产热:ATP+H2O→ADP+Pi+热。临床上可因服用氟烷而诱发恶性发烧。 恶性发烧是一种罕见的遗传缺陷性疾病,其发病率占儿童的1/15000,成人的1/50000-1/100000。病人常因服用某种药物,如吸...
医源资料库;医源图书馆;教材类;临床生物化学ThegreatbetrayalFraudinscience
...rehighstandardstotheconductofscientificresearch.Severalinterestingchapters,titled“Theproblemsofpeerreview,““Authorship,ownership:problemsofcredit,plagiarism,andintellectualproperty,“and“Laboratorytolaw:theproblemsofinstitutionswhenmisconductischarged“willbeenlighteningandchallengingtorea...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第2期ProlongedOutbreakofInfectionDuetoTEM-21-ProducingStrainsofPseudomonasaeruginosaandEnterobacteriainaNursingHome
...rom18patientslivinginanursinghome.Theseisolateshadadelayeddevelopmentofaredpigmentandexhibitedasimilarantibiotype(resistancetoall-lactamsexceptforimipenemandtogentamicin,tobramycin,netilmicin,ciprofloxacin,andrifampin)associatedwiththeproductionoftheTEM-21-lactamaseandatypeII3‘-N-aminoglycosideace...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期MitogenicEffectsofCytokinesonSmoothMuscleAreCriticallyDependentonProteinKinaseAandAreUnmaskedbySteroidsandCyclooxygenaseInhibitors
...nducedautocrinefactors.Thesefindingssuggestamechanismbywhichmainstreamtherapiessuchascorticosteroidsorcyclooxygenaseinhibitorscouldfailtoaddressorexacerbatethepathogenicsmoothmusclegrowththatoccursinobstructiveairwayandcardiovasculardiseases.Airwaysmoothmuscle(ASM)hyperplasiaisamajorfeatureoftheairw...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期流式细胞术定量检测细胞凋亡3种方法的比较研究
...,徐州221002关键词:凋亡;流式细胞术;AnnexinV TUNEL PI 摘 要 目的:探讨流式细胞术定量检测细胞凋亡3种方法的价值。方法:同时使用PI染色、TUNEL及AnnexinV/PI3种方法定量检测地塞米松处理小鼠的胸腺细胞凋亡发生率。...
合作平台;医学论文;临床医学与专科论文;检验医学处在临床研究十字路口的靶向药PI3K
PI3K对于抗肿瘤药物的研发者来说是一个非常明显的靶标。被正式命名为磷脂酰肌醇-3-激酶(PI3K)的酶,所参与的人体内功能可以列出一串长长的清单,这些功能促成了细胞生存能力。通过向信号分子中加入磷酸,PI3K引发了一连...
药品天地;专业药学;药学研究Proteinkinasecascadesintheregulationofcardiachypertrophy
...owthareregulatedinlargepartbythegrowthhormone/IGFaxisviasignalingthroughthePI3K/Aktpathway.Incontrast,pathologicalorreactivecardiacgrowthistriggeredbyautocrineandparacrineneurohormonalfactorsreleasedduringbiomechanicalstressthatsignalthroughtheGq/phospholipaseCpathway,leadingtoanincreaseincytosolicc...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期OSU-03012PromotesCaspase-IndependentbutPERK-,CathepsinB-,BID-,andAIF-DependentKillingofTransformedCells
...aspartofananti-inflammatorytherapeuticregimenalsohadalowerincidenceofdevelopingcancer,suggestivethatCOX2inhibitorswerecancerpreventative(KashfiandRigas,2005;Narayananetal.,2006).However,asthesensitivityoftumorcellstoCOX2inhibitorswasinvestigatedingreaterdetail,itbecameapparentthatexpressionofCOX2did...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期VitaminDinsufficiencyinchildren,adolescents,andyoungadultswithcysticfibrosisdespiteroutineoralsupplementation
...VAS,JIS,andBSZ)andNephrology(MBL),DepartmentofPediatrics,TheChildren‘sHospitalofPhiladelphia,andthetheDepartmentofBiostatisticsandEpidemiology,CenterforClinicalEpidemiologyandBiostatistics(MBL),UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,PA2SupportedbytheCysticFibrosisFoundationandtheGen...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第6期胃腺癌组织PI3Kp85α、pAkt及Ki67表达和意义
【摘要】 目的利用组织芯片检测PI3Kp85α、pAkt、Ki67蛋白在胃黏膜、胃腺癌及癌旁组织的表达情况,探讨其意义。方法用免疫组化技术检测了30例胃黏膜组织、85胃腺癌组织(分为高、中、低分化3种)及其癌旁组织中PI3Kp85α...
医源资料库;在线期刊;齐鲁医学杂志;2010年第25卷第2期