血链球菌与nifs、nifu基因同源序列分析
...othernitrogenfixingbacteriaenzymegene-nifsandnifugene.Thenifs,nifuhomologousratewas72%and71%,respectively.nifsfamilywasanewclassofpyridoxalphosphate-dependentenzymes,itshomologousratewithATCC10556800bpgenefragmentwas63%.TwostrainsofS.sanguishadthesamenifsandnifugeneasATCC10556,otheroralStreptococcus...
合作平台;医学论文;临床医学与专科论文;检验医学MolecularregulationofHDLmetabolismandfunction:implicationsfornoveltherapies
...paratelipoproteinsofdifferentdensities.Severalstudieswerepublishedinthe1970sreportinganinverseassociationbetweenplasmaHDLcholesterol(HDL-C)levelandcoronaryheartdisease(1),confirmedsincethenbynumerousadditionalstudiesthroughouttheworld.HDL-Cwasfirstendorsedasaformalindependentriskfactorforcoronaryhea...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第12期BroadlyReactiveNestedReverseTranscription-PCRUsinganInternalRNAStandardControlforDetectionofNorovirusesinStoolSamples
...ndasetofnineinnerprimersforthesecond,comprisingthereversesequencesofprimersSR46,SR48,SR50,andSR52,andfivenoveloligonucleotidesequences(113-1,113-2,115-1,115-2,and115-3).ThespecificityofthenRT-PCRwasconfirmedbytesting61stoolscontainingentericvirusesotherthannoroviruses.Incomparativeassaysoneitherstoo...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期Modificationofcytosoliccalciumsignalingbysubplasmalemmalmicrodomains
...ToinvestigatethehypothesisthatNa+concentrationinsubplasmalemmalmicrodomainsregulatesCa2+concentrationsincellularmicrodomains(md),thecytosol(cyt),andsarcoplasmicreticulum(SR;sr),wemodeledtransporteventsinthosecompartments.Inputstothemodelwereobtainedfrompublishedmeasurementsindescendingvasarectaperic...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第6期“好”胆固醇也会引发心脏病基因分析质疑高水平高密度脂蛋白胆固醇有益健康
...终开始新的循环。而由SCARB1基因形成的蛋白质——被称为SR-B1——则帮助这一沉积过程的发生。但是没有SR-B1的小鼠的高密度脂蛋白粒子则充满了胆固醇,从而无法再进行这一沉积过程。Rader于是寻思类似的过程是否也会发生在人...
医药经济;生物技术;技术要闻InhibitionofHumanNeutrophilChemotaxisbyEndogenousCannabinoidsandPhytocannabinoids:EvidenceforaSiteDistinctfromCB1andCB2
...5-methyl-1,3-benzenediol(O-1602)inhibitsmigration,withanIC50valueof33nM.Thisreportedprofileofagonistefficacyandpotencyparallelswiththepharmacologyofthenovel“abnormal-cannabidiol“receptororarelatedorphanGprotein-coupledreceptor,whicharealreadyknowntomodulatecellmigration.Althoughhavingnoeffectalo...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期UniquePathwayforCholesterolUptakeinFatCells
...fromtheparticleintothecell.1WiththediscoverythatthescavengerreceptortypeBI(SR-BI)actsasthehepaticHDLreceptor,2thefinaleventsofHDLcholesteroldeliveryhavebeenwellcharacterized:HDLbindstoSR-BIthroughapolipoproteinAI(apoAI),thecholesterylester(CE)cargoofHDLisselectivelyunloadedintothecellwhereitistraffi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第9期新靶点研究促进减肥新药开发
...开发了一种选择性内源性大麻素CB1受体拮抗剂Rimonabant(SR141716A)。2004年8月,该公司公布了Ri-monabant的500个临床中心参与的随机、双盲、安慰剂对照的Ⅲ期临床试验结果。结果表明,Rimonabant不仅能有效减肥,还可同时作用于与心...
医学教育;科教新闻AdipophilinEnhancesLipidAccumulationandPreventsLipidEffluxFromTHP-1Macrophages
...eofmodifiedlow-densitylipoprotein(LDL)bymacrophagesthroughscavengerreceptorsresultsinlipiddropletsaccumulationandfoamcellformation.Excesslipiddepositioninmacrophageshasbeenreportedtomodulateexpressionofseveralgenesincludingadipophilin.Inthisstudy,weinvestigatedthefunctionofadipophilininlipidaccumula...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第3期血脂异常的诊治进展
...蛋白HDL2LPLFFA游离脂肪酸EACsEACsLCATLCATHTGLCETPCETP肝脏HDL受体(SR-B1)(?)外周细胞HDL受体肠肝巨噬细胞AHDL在血浆中的代谢LCAT:卵磷脂-胆固醇酰基转移酶LPL:脂蛋白脂酶ABCA1:ATP结合盒A1CETP:胆固醇酯转移蛋白HTGL:甘油三酯脂酶SR-B1:清道夫受...
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