SpecificC-TerminalCleavageandInactivationofInterleukin-8byInvasiveDiseaseIsolatesofStreptococcuspyogenes
...effectivelypreventingIL-8C-terminusmediatedendothelialtranslocationandsubsequentrecruitmentofneutrophils.Streptococcuspyogenescausesaspectrumofdisease,rangingfrompharyngitistonecrotizingsofttissueinfectionstotoxicshock.Lethalnecrotizinginfectionsarecharacterizedbyanabsenceofneutrophilsatthesiteofbac...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第17期MultispacerTypingTechniqueforSequence-BasedTypingofBartonellaquintana
...volutionaryBiologyCenter,UppsalaUniversity,Uppsala,SwedenABSTRACTBartonellaquintanaisaworldwidefastidiousbacteriumoftheAlphaproteobacteriaresponsibleforbacillaryangiomatosis,trenchfever,chroniclymphadenopathy,andculture-negativeendocarditis.TherecentgenomesequencingofaB.quintanaisolateallowedustopro...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期ExternalQualityAssessmentforMolecularDetectionofBordetellapertussisinEuropeanLaboratories
...isVrijeUniversiteitBrusselULB-Erasme,BrusselsInstitutdePathologieetdeGenetique,GerpinnesC.H.RegionaldelaCitadelle,Liege,BelgiumGGGD,MunicipalHealthLaboratory,AmsterdamSt.ElisabethHospital,Tilburg,TheNetherlandsC.H.deVersailles,LeChesnayInstitutdeBacteriologie,Strasbourg,FranceHealthProtectionAgency,...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期BenefitofHepatitisCVirusCoreAntigenAssayinPredictionofTherapeuticResponsetoInterferonandRibavirinCombinationTherapy
...ciallyavailablecoreantigen(Ag)assays,LumipulseOrthoHCVAg(Lumipulse-Ag),andaquantitativeHCVRNAPCRassay,CobasAmplicorHCVMonitortest,version2(AmplicorM),toestimatethepredictivebenefitofasustainedviralresponse(SVR)andnon-SVRin44genotype1bpatientstreatedwithinterferon(IFN)andribavirin.HCVcoreAgnegativity...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期RestrictingZap70ExpressiontoCD4+CD8+ThymocytesRevealsaTCellReceptor–dependentProofreadingMechanismControllingtheCompletionofPositiveSelectio
...nscontroversialwhethertheyonlyservetoinitiatethisprocess,orwhethertheyarerequiredthroughouttopromotethymocytedifferentiationandsurvival.Toaddressthisissue,wehavedevisedanovelapproachtointerferewiththymocyteTCRsignalinginadevelopmentalstage-specificmannerinvivo.WehavereconstitutedmicedeficientforZap7...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第3期RestrictingZap70ExpressiontoCD4+CD8+ThymocytesRevealsaTCellReceptor–dependentProofreadingMechanismControllingtheCompletionofPositiveSelectio
...nscontroversialwhethertheyonlyservetoinitiatethisprocess,orwhethertheyarerequiredthroughouttopromotethymocytedifferentiationandsurvival.Toaddressthisissue,wehavedevisedanovelapproachtointerferewiththymocyteTCRsignalinginadevelopmentalstage-specificmannerinvivo.WehavereconstitutedmicedeficientforZap7...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第3期Conditionaldeletionrevealsacell-autonomousrequirementofSLP-76forthymocyteselection
...naltransductioninprimarythymocytesandperipheralTlymphocytes.ToevaluatetherequirementsforSLP-76intheseevents,weusedacre-loxPapproachtogeneratemicethatconditionallydeleteSLP-76aftertheDN3checkpoint.ThesemicedevelopDPthymocytesthatexpresstheTCRonthesurface,butlackSLP-76atthegenomicDNAandproteinlevels.T...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第7期Deathversussurvival:functionalinteractionbetweentheapoptoticandstress-inducibleheatshockproteinpathways
...saggregate,refold,andrenaturemisfoldedproteinsoffsetstheotherwisefatalconsequencesofdamagingstimuli(4,5).ThisprotectivefunctionofHspshasbeensuggestedtoreflecttheirabilitytosuppressseveralformsofcelldeath,includingapoptosis.TheHsp70andHsp90subfamiliesarecomposedofanN-terminalATPasedomainandaC-termina...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期Hypoxia-inducedneutrophilsurvivalismediatedbyHIF-1–dependentNF-Bactivity
...ne,UniversityofCambridge,Addenbrooke‘sandPapworthHospitals,Cambridge,CB22QQ,UK2DepartmentofPathology,UniversityofCambridge,Cambridge,CB21QP,UK3MolecularBiologySection,DivisionofBiologicalSciences,UniversityofCalifornia,SanDiego,LaJolla,CA92093Neutrophilsarekeyeffectorcellsoftheinnateimmuneresponse...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第1期MultilocusSequenceTypingofStaphylococcusaureusIsolatedfromHigh-Somatic-Cell-CountCowsandtheEnvironmentofanOrganicDairyFarmintheUnitedKing
...wasvariationintherateofisolationofS.aureus(9.5to43.8%)fromindividualmammaryquarters,althoughnoS.aureusisolatesweredetectedinthemilksamplescollectedfromtheheifers.Onehundredninety-oneS.aureusisolatesweredetectedfromcowmilksamples(n=182),milkingmachineclusters(n=4),farmpersonnel(n=4),andtheenvironment...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期