罗非昔布较低剂量也增加了重度心脏病的风险
...的资料,以确定与使用选择性与非选择性COX-2NSAIDs有关的MI和忽发心性死亡的风险。共纳入了230万随访人年。25mg/天)增加了3.58倍重度心脏病风险(p=0.016)。但即使以较低剂量使用罗非昔布,出现MI或忽发心性死亡的可能也比用塞来...
行业资讯;临床快报;心脑血管相关研究称抑制亲环蛋白D可能避免再灌注的损伤
...素及同型物可能让器官避免缺血/再灌注损伤后(见于如MI和中风)的坏死性死亡。线粒体通透性转换孔(mPT)是线粒体肿胀和破裂的一种钙依赖性调节物,莫尔肯金和同事在3月31日《自然》杂志(Nature2005;434:658-662)中指出,他们培...
行业资讯;临床快报;心脑血管相关在PCI前切除血栓可增加心肌灌注量
...(PCI)前进行冠脉内血栓切除术可能改善急性心肌梗死(MI)患者的心肌再灌注。TheirryLefèvre(法国巴黎心血管研究所)及其同事指出:“自发或经皮介入治疗可引起斑块和血栓碎片栓塞末梢血管,最终可能导致了末梢冠脉分支...
行业资讯;临床快报;心脑血管相关血管成形术前氯吡格雷降低冠心病患者死亡率
...91例年龄为18至75岁的患者,他们在ST段抬高的心肌梗死(STEMI)发生后12小时内入院。其中1863例在血管成形术前被随机给予Plavix,930例在介入手术前被随机给予安慰剂。所有患者均使用阿司匹林(第1天150至325mg,然后75至162mg)治疗...
行业资讯;临床快报;心脑血管相关DANAMI-2研究
TheDANAMI-2TrialDanishTrialinAcuteMyocardialInfarction-2PresentedattheAmericanCollegeofCardiology51stAnnualScientificSessionAtlanta,GADr.HenningRudAndersenfortheDANAMI-2investigatorsHigh-riskSTelevationMIpatients(4mmelevation),Sx12hrs5PCIcenters(n=443)and22referringhospitals(n=1,129),transferin3hrsL...
医源资料库;医学文档库;心血管相关DELIVER研究
TheDELIVERTrialAMulti-Center,RandomizedStudyofthePaclitaxel-ElutingStentintheTreatmentofPatientswithDeNovoCoronaryArteryLesionsPresentedatACC2003LateBreakingClinicalTrialsDELIVER:StudyDesign1,043patientswithdenovolesionsinnativecoronaryarteries25mminlengthand2.5to4.0mmindiameter,randomizedto:RXACHIE...
医源资料库;医学文档库;心血管相关PREMIER研究
...canCollegeofCardiologyScientificSessions2005PresentedbyDr.WDouglasWeaverPREMIERTrialEndpoints(90days):Primary:Leftventricularenddiastolicvolumeindex(LVEDVI)changeSecondary:LVEDVIchangeat30days;LVESV,LVejectionfractionandLVsphericitychanges;clinicaleventsPREMIERTrialPresentedatACCScientificSessions20...
医源资料库;医学文档库;心血管相关REACT研究
...,orsevereheartfailureat6monthsREACT:6monthresultsPresentedatAHA2004427AcuteMIpatientswithfailedthrombolysisaspirinandthrombolytictherapy(60%receivedstreptokinase)within6hoursofchestpainonset,50%resolutionofSTchangesonECGat90minutes42%anteriorinfarctionsConservativeTreatmentIVUnfractionatedHeparinfor...
医源资料库;医学文档库;心血管相关COMMITCCS-2研究
PerspectiveonCOMMIT/CCS-2TrialofMetoprololinSTEMIChristopherCannon,M.D.BrighamandWomen’sHospitalBoston,MAFirstimpressionWow!?Ihadpredicteddramaticbenefitwithmultiple0’sinthePvalueOlderB-blockertrials(upto1986)27,000patientsfrom28trialsMeta-analysis:B-blocker(3.7%)Control(4.3%)16%relativeriskredu...
医源资料库;医学文档库;心血管相关C-SIRIUS研究
TheC-SIRIUSStudyATheCanadianMulti-Center,Randomized,Double-BlindStudyoftheSirolimus-ElutingStentintheTreatmentofPatientswithDeNovoCoronaryArteryLesionsErickSchampaert,EricA.Cohen,FrancoisReeves,LaurenceM.Title,M.DeanTraboulsi,RichardR.Mildenberger,DominicRaco,SylvainPlante,JeffreyPopmaPresentedatACC...
医源资料库;医学文档库;心血管相关