EndotoxinInducesToll-LikeReceptor4ExpressioninVascularSmoothMuscleCellsviaNADPHOxidaseActivationandMitogen-ActivatedProteinKinaseSignaling
【摘要】Objective-Toll-likereceptor4(TLR4)playsamajorrolemediatingendotoxin-inducedcellularinflammationandregulatesvascularsmoothmusclecell(VSMC)proliferation,whichisrelatedtoatherogenesisandrestenosis.Thisstudywasconductedtoinvestigatethemechanismsinvolvedinlipopolysaccharide(LPS)-inducedTLR4ex...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第12期Interleukin-6AlterstheCellularResponsivenesstoClopidogrel,Irinotecan,andOseltamivirbySuppressingtheExpressionofCarboxylesterasesHCE1andHCE2
...creasedcapacityofhydrolysis.Inthisstudy,weprovideamolecularexplanationlinkingcytokinesecretiondirectlytothedecreasedcapacityofhydrolyticbiotransformation.InbothprimaryhepatocytesandHepG2cells,treatmentwithIL-6decreasedtheexpressionofhumancarboxyl-esterasesHCE1andHCE2byasmuchas60%.Thedecreasedexpress...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第9期多发性骨髓瘤细胞激活内皮细胞脑源性神经营养因子自分泌环
...后的HUVEC不仅上清中BDNF的含量增加[分别为(12.4±5.1)ng/ml和(31.6±7.2)ng/ml,P〈0.05],RT-PCR结果显示HUVEC常规表达BDNF,与RPMI8226细胞共培养后HUVECBDNF表达量约为前者的1.7倍(P〈0.05);单独培养的HUVEC几乎不表达TrkB,...
行业资讯;临床快报;肿瘤相关Partialresolutionofacuteascendingmotorpolyneuropathyafterenucleationofaneyewithmetastaticmelanoma
JulesSteinEyeInstitute,100SteinPlaza,LosAngeles,CA90095-7006,USACorrespondenceto:GJBenSimonJulesSteinEyeInstitute,100SteinPlaza,LosAngeles,CA90095-7006,USA;guybs@barak-online.netAcceptedforpublication7November2003Keywords:polyneuropathy;metastaticmelanoma;uveitisMalignantmelanomaisanimmunologicaltum...
医源资料库;在线期刊;英国眼科学杂志;2004年第88卷第6期RoleofChemR23indirectingthemigrationofmyeloidandplasmacytoiddendriticcellstolymphoidorgansandinflamedskin
...icularTcellarea.ChemR23+DCswerealsoobservedindermisfromnormalskin,whereasLangerhanscellswerenegative.Chemerinexpressionwasselectivelydetectedontheluminalsideofhighendothelialvenulesinsecondarylymphoidorgansandindermalendothelialvesselsoflupuserythematosusskinlesions.Chemerin+endothelialcellsweresurr...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第4期高效液相色谱/大气压化学电离质谱快速分析水中痕量有机磷农药
...解离(CID)碎片谱。二嗪农和喹硫磷的检出限可低达0.09ng和0.1ng。Abstract Arapidanalysisofsixorganophosphorouspesticides(acephate,parathion-methyl,fenitrothion,quinalphos,diazinon,phoxim)wasrealizedbythemethodofhighperformanceliquidchromatography/atmosphericchemicalionizationm...
药品天地;专业药学;实验技术;色谱技术;色谱分析实例InhibitionofTNFreceptor1internalizationbyadenovirus14.7Kasanovelimmuneescapemechanism
...(14.7K)isaninhibitorofTNF-inducedapoptosis,butthemolecularmechanismunderlyingthisprotectiveeffecthasnotyetbeenexplainedexhaustively.TNF-mediatedapoptosisisinitiatedbyligand-inducedrecruitmentofTNFreceptor–associateddeathdomain(TRADD),Fas-associateddeathdomain(FADD),andcaspase-8tothedeathdomainofTN...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期ApolipoproteinEe4alleleaffectsriskofhyperhomocysteinemiaintheelderly
...LicastroandChristopherPatterson1FromtheDepartmentofInternalMedicine,Cardioangiology,andHepatology,UniversityHospitalSOrsola-Malpighi,Bologna,Italy(GR,PF,FMa,andFMo);theDepartmentofExperimentalPathology,UniversityofBologna,Italy(MCandFL);theDistrictHealthUnitofLugo,LocalHealthUnitofRavenna,Ravenna,It...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第6期甲亢突眼症中医如何治疗?
...均缩小2.3毫米(P<0.01),血清T3、T4浓度由治疗前的3.7±1.3ng/mL和16.6±6.0μg/dl分别降到1.5±0.5ng/mL(P<0.001)和10.2±4.0μg/dl(P<0.01)。其中单用中药治疗5例也均明显好转。1例恶性突眼(2类5级)右眼较左眼突出,右眼裂、左内聚稍差,第4对...
医源资料库;医源图书馆;疾病类;甲亢防治250问EnhancedexpressionofEGFreceptorinamodelofsalt-sensitivehypertension
【关键词】hypertensionNephrologyResearchandTrainingCenter,ComprehensiveCancerCenter,andCellAdhesionandMatrixResearchCenter,DivisionofNephrology,DepartmentsofMedicineandPhysiologyandBiophysics,UniversityofAlabamaatBirmingham,andDepartmentofVeteransAffairsMedicalCenter,Birmingham,AlabamaABSTRACTC...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第9期