Down-RegulationofNa+/Ca2+ExchangerbyFluvastatininRatCardiomyoblastH9c2Cells:InvolvementofRhoBinNa+/Ca2+ExchangermRNAStability
...,Japan(T.I.)DepartmentofPharmacologyandToxicology,GraduateSchoolofPharmaceuticalScience,KyushuUniversity,Fukuoka,Japan(H.K.)AbstractWeinvestigatedtheeffectoffluvastatin(Flv),anHMG-CoAreductaseinhibitor,onNa+/Ca2+exchanger1(NCX1)expressioninH9c2cardiomyoblasts.Reversetranscriptase-polymerasechainreac...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第2期TonsilEpithelialFactorsMayInfluenceOropharyngealHumanImmunodeficiencyVirusTransmission
...epitheliumhasbeenimplicatedinhumanimmunodeficiencyvirus(HIV)pathogenesis,butitsroleinoraltransmissionremainscontroversial.Tostudycharacteristicsofthistissue,whichmayinfluencesusceptibilityorresistancetoHIV,weperformedmicroarrayanalysisofthetonsilepithelium.Ourdatarevealedthatgenesrelatedtoimmunefunc...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第8期SelectiveCyclooxygenase-2InhibitionWithCelecoxibDecreasesAngiotensinII-InducedAbdominalAorticAneurysmFormationinMice
【摘要】Objective-Inflammationplaysanintegralroleinthedevelopmentofabdominalaorticaneurysms(AAAs),andtheexpressionofcyclooxygenase(COX)-2isincreasedinaneurysmaltissuecomparedwithnormalaorta.Nonsteroidalanti-inflammatorydrugs,whichinhibittheactivityofCOX-1andCOX-2,decreaseAAAexpansioninhumansanda...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第5期TransientNeonatalEstrogenExposuretoEstrogen-DeficientMice(AromataseKnockout)ReducesProstateWeightandInducesInflammationinLateLife
...malemicetoestrogensisassociatedwithage-relatedchangesinprostatesizeandinductionofepithelialhyperplasiaanddysplasia.Whetherthesechangesdirectlyresultfromsystemicestrogenadministrationorindirecteffectsofestrogensonsystemictestosteronelevelsisunclear.Wehaveaddressedthisquestionusingaromatase-knockout(A...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第6期UseoftheDuplexTaqManPCRSystemforDetectionofShiga-LikeToxin-ProducingEscherichiacoliO157
InstituteofMicrobiologyandBiochemistry,NationalTaiwanUniversity,Taipei,Taiwan106,RepublicofChinaABSTRACTReal-timePCRassayshavebeenappliedforthedetectionandquantificationofpathogensinrecentyears.InthisstudytwocombinationsofprimersandfluorescentprobesweredesignedaccordingtothesequencesoftherfbEscheric...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第6期ExpressionofTumorNecrosisFactorReceptor-1inArterialWallCellsPromotesAtherosclerosis
【摘要】Objective-Mechanismsbywhichtumornecrosisfactor-(TNF)contributestoatherosclerosisremainlargelyobscure.WethereforesoughttodeterminetheroleofthearterialwallTNFreceptor-1(TNFR1)inatherogenesis.MethodsandResults-Carotidartery-to-carotidarteryinterpositiongraftingwasperformedwithtnfr1-/-andcon...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第5期RenalexpressionandlocalizationofthefacilitativeglucosetransportersGLUT1andGLUT12inanimalmodelsofhypertensionanddiabeticnephropathy
...Melbourne,Fitzroy,Victoria,Australia3065ABSTRACTRenaltubularglucosereabsorptionismediatedbyfacilitativeglucosetransporter(GLUT)proteinsandenergy-dependentsodiumglucoseluminaltransporters.Glucosetransportinthediabetickidneyisupregulatedandhasbeenimplicatedinthepathogenesisofprogressivediabeticnephrop...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第1期DevelopmentofaNestedPCRMethodTargetingaUniqueMulticopyElement,ISMap02,forDetectionofMycobacteriumaviumsubsp.paratuberculosisinFecalSample
USDA-ARS,NationalAnimalDiseaseCenter,BacterialDiseasesofLivestockResearchUnit,2300DaytonRd.,Ames,Iowa50010ABSTRACTThisstudydescribesthedevelopmentofanestedPCRassaythatusesauniqueelement(ISMap02)forMycobacteriumaviumsubsp.paratuberculosisthatispresentatsixcopieswithinthegenome.Inaddition,thesensitivi...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期BlockadeoftheInteractionBetweenPD-1andPD-L1AcceleratesGraftArterialDiseaseinCardiacAllografts
...RACTBackground—Programmeddeath-1(PD-1),amemberoftheCD28family,hasbeenidentified.PD-1isinvolvedinthenegativeregulationofsomeimmuneresponses.WeevaluatedtheroleofPD-ligand1(PD-L1)ingraftarterialdisease(GAD)ofcardiacallograftsandinsmoothmusclecells(SMCs).MethodsandResults—C57BL/6murineheartsweretran...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第11期RoleofAntioxidant-1inExtracellularSuperoxideDismutaseFunctionandExpression
...dinthevasculature.Copper-containingenzymesrequirecopperchaperonesfortheiractivityhoweverthechaperonewhichdeliverscoppertoSOD3hasnotpreviouslybeendefined.Atox1isacopperchaperoneproposedtodelivercoppertothetrans-Golginetwork.BecauseSOD3issecretedviathetrans-Golginetwork,wesoughttodeterminewhetherAtox1...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第4期