Diabetescausesinhibitionofglucose-6-phosphatedehydrogenaseviaactivationofPKA,whichcontributestooxidativestressinratkidneycortex
...andStantonRC.JBiolChem275:40042-40047,2000).Thepurposeofthisstudywastodeterminewhetherthesefindingsoccurindiabeticrats(inducedbystreptozotocin)comparedwithcontrol.G6PDactivityandaccordinglyNADPHlevelsandglutathionelevelsweresignificantlydecreasedindiabetickidneyscomparedwithcontrolkidneys.Lipidperox...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第11期CoordinatecontrolofprostaglandinE2synthesisanduptakebyhyperosmolarityinrenalmedullaryinterstitialcells
...deprivation,prostaglandinE2(PGE2),formedbyrenalmedullaryinterstitialcells(RMICs),feedbackinhibitstheactionsofantidiuretichormone.InterstitialPGE2concentrationsrepresentthenetofbothPGE2synthesisbycyclooxygenase(COX)andPGE2uptakebycarrierssuchasPGT.WeusedculturedRMICstoexaminetheeffectsofhyperosmolari...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第2期DiminishedLipoxinBiosynthesisinSevereAsthma
...,however,merelyanexaggerationoftheeosinophilicinflammationthatcharacterizesmildtomoderateasthma;rather,severeasthmapresentsuniquefeatures.Althougharachidonicacidmetabolismiswellappreciatedtoregulateairwayinflammationandreactivity,alterationsinthebiosyntheticcapacityforbothpro-andantiinflammatoryeico...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第10期StatinsUpregulatePCSK9,theGeneEncodingtheProproteinConvertaseNeuralApoptosis-RegulatedConvertase-1ImplicatedinFamilialHypercholesterolemia
FromtheLaboratoryofHyperlipidemiaandAtherosclerosisResearchGroup(G.D.,H.W.,J.D.,L.B.)andtheLaboratoryofBiochemicalNeuroendocrinology(A.C.,N.G.S.,A.P.),ClinicalResearchInstituteofMontreal,Quebec,Canada.ABSTRACTObjective—Neuralapoptosis-regulatedconvertase(NARC)-1isthenewestmemberoftheproproteinconv...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第8期Thedietaryguidelineforsodium:shouldweshakeitup?No
...yHinesBoulevard,Dallas,TX75235.ABSTRACTThecurrentUSdietaryguidelineforsodiumisalimitof2.4g/dor6gNaCl/d.Thisamountofsodiumisfarinexcessofanyphysiologicneedandislikelyanessentialthoughnotbyitselfsufficientprimarycauseofhypertensionaswellasacontributortomanyothercardiovascularandrenalabnormalities.Thee...
医源资料库;在线期刊;美国临床营养学杂志;2000年71卷第5期Plasmafattyacidcompositionandincidenceofdiabetesinmiddle-agedadults:theAtherosclerosisRiskinCommunities(ARIC)Study
...sSPankowandJohnHEckfeldtfortheARICStudyInvestigators1FromtheDivisionofEpidemiology,SchoolofPublicHealth(LW,ARF,andJSP),andtheDepartmentofLaboratoryMedicineandPathology(JHE),UniversityofMinnesota,Minneapolis,andtheCardiovascularHealthProgram,CentersforDiseaseControlandPrevention,Atlanta(Z-JZ).2Suppor...
医源资料库;在线期刊;美国临床营养学杂志;2003年78卷第1期AldosteroneandAngiotensinIISynergisticallyInduceMitogenicResponseinVascularSmoothMuscleCells
theDepartmentofMolecularandCellularBiology,DivisionofMedicalBiochemistryandCardiovascularBiology,EhimeUniversitySchoolofMedicine,Tohon,Ehime,Japan.AbstractInteractionbetweenaldosterone(Aldo)andangiotensinII(AngII)inthecardiovascularsystemhasbeenhighlighted;however,itsdetailedsignalingmechanismispoor...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第9期Smoking-InducedMonocyteDysfunctionIsReversedbyVitaminCSupplementationInVivo
...monocytefunction.ThisstudyinvestigatedthenegativeeffectsofsmokingonmonocytemigratoryresponsivenesstoVEGF-AandtheusefulnessofvitaminCtopreventsmoking-inducedmonocytedysfunction.MethodsandResults-Thechemotacticresponseofisolatedmonocytesfromacohortof17non-smokersand10smokerstowardVEGF-Awasassessed.VEG...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第1期Plant-basedfoodsandpreventionofcardiovasculardisease:anoverview
...ds,includingmono-andpolyunsaturatedfattyacids,n-3fattyacids,antioxidantvitamins,minerals,phytochemicals,fiber,andplantprotein.Indietarypractice,healthyplant-baseddietsdonotnecessarilyhavetobelowinfat.Instead,thesedietsshouldincludeunsaturatedfatsasthepredominantformofdietaryfat(eg,fatsfromnaturalliq...
医源资料库;在线期刊;美国临床营养学杂志;2003年78卷第3期InfantsdiscriminatebetweennaturalandsyntheticvitaminE
...ail.etsu.edu.ABSTRACTBackground:Inadults,RRR--tocopherylacetate(naturalvitaminE)hasapproximatelytwicethebiologicalactivityofall-rac--tocopherol(syntheticvitaminE).Similarstudieshavenotbeendoneinterminfants.Objective:WeevaluatedthevitaminEandantioxidantstatusofterminfantsfedformulasdifferingintheamou...
医源资料库;在线期刊;美国临床营养学杂志;2003年77卷第4期