SelectiveActivationofthec-JunNH2-terminalProteinKinaseSignalingPathwaybyStimulatoryKIRintheAbsenceofKARAP/DAP12inCD4+TCells
...e,CampusdeLuminy,Case906,13288MarseilleCedex09,France AbstractTopAbstractIntroductionMaterialsandMethodsResultsDiscussionReferencesActivationofCD4+Tcellsisgovernedbyinterplaybetweenstimulatoryandinhibitoryreceptors;predominanceofstimulatorysignalsfavorsautoimmunereactions.Inpatientswithrheumatoida...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第3期CirculatingSecretoryPhospholipaseA2ActivityandRiskofIncidentCoronaryEventsinHealthyMenandWomen
【摘要】Objective-ToassesstheassociationbetweensecretoryphospholipaseA2(sPLA2)activity,whichencompassesseveraltypesofsPLA2,andcardiovasculardisease(CAD)inhealthyindividuals.MethodsandResults-Weinvestigatedthisassociationinanestedcase-controlstudyamongthe25663participantsinEPIC-Norfolkcohort.Case...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第5期TheCX3CChemokineFractalkineInducesVascularDysfunctionbyGenerationofSuperoxideAnions
【摘要】Objective-Thechemokinefractalkineactivatesplateletsandinducesleukocyteadhesiontotheendothelium.Expressionoffractalkineanditsreceptor,CX3CR1,iselevatedincoronaryarterydisease.Weassessedtheeffectsoffractalkineonvascularfunctioninisolatedrataorta.MethodsandResults-CX3CR1expressionwasdemonst...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第1期DiminishedLipoxinBiosynthesisinSevereAsthma
PulmonaryandCriticalCareMedicineandPartnersAsthmaCenter,DepartmentofInternalMedicine,BrighamandWomen‘sHospital,HarvardMedicalSchoolPulmonaryPhysiologyProgram,HarvardSchoolofPublicHealth,Boston,MassachusettsWesternAustralianInstituteforMedicalResearch,UWACentreforMedicalResearch,UniversityofWestern...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第10期Anti-LOX-1RescuesEndothelialFunctioninCoronaryArteriolesinAtheroscleroticApoEKnockoutMice
...hypothesizedthatatherosclerosisinhibitsNO-mediatedendothelium-dependentdilationofcoronaryarteriolesthroughinteractionofox-LDLwithitsreceptor,LOX-1,throughtheproductionofO2ÿ-inendothelialcells.MethodsandResults-Weassessedtheroleofox-LDLinendothelialdysfunctioninamurinemodelofatherosclerosis(ApoE...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第4期SeparatingTransrepressionandTransactivation:ADistressingDivorcefortheGlucocorticoidReceptor?
【关键词】SeparatingGlucocorticoids(corticosteroids)arehighlyeffectiveincombatinginflammationinthecontextofavarietyofdiseases.However,clinicalutilitycanbecompromisedbythedevelopmentofsideeffects,manyofwhichareattributedtotheabilityoftheglucocorticoidreceptor(GR)toinducethetranscriptionof,ortran...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期Smoking-InducedMonocyteDysfunctionIsReversedbyVitaminCSupplementationInVivo
【摘要】Objective-Theroleofantioxidantsinpreventingvasculardiseaseremainscontroversial.Vascularendothelialgrowthfactor(VEGF-A)isimportantforendothelialandmonocytefunction.ThisstudyinvestigatedthenegativeeffectsofsmokingonmonocytemigratoryresponsivenesstoVEGF-AandtheusefulnessofvitaminCtoprevents...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第1期AngiotensinIIAmplifiesMacrophage-DrivenAtherosclerosis
...Pathology,VanderbiltUniversitySchoolofMedicine,Nashville,Tenn.ABSTRACTObjective—WeevaluatedtheroleofangiotensinII(AII)inamarrow-derivedmacrophage-drivenmodelofatherosclerosis.MethodsandResults—Eight-week-oldC57BL/6wild-typemicewerereconstitutedwithbonemarrowharvestedfromapolipoproteinE-deficient...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第11期EarlyImmuneResponsetotheComponentsoftheTypeIIISystemofPseudomonasaeruginosainChildrenwithCysticFibrosis
DepartmentofMicrobiologyandMolecularGenetics,MedicalCollegeofWisconsin,Milwaukee,WisconsinDepartmentofPediatrics,MedicalCollegeofWisconsin,Milwaukee,WisconsinDepartmentofPediatrics,UniversityofWisconsinMedicalSchool,Madison,WisconsinPulmonaryCriticalCareMedicineBranch,NationalHeart,Lung,andBloodInst...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期Plant-basedfoodsandpreventionofcardiovasculardisease:anoverview
FrankBHu1FromtheDepartmentofNutrition,HarvardSchoolofPublicHealth,Boston.2PresentedattheFourthInternationalCongressonVegetarianNutrition,heldinLomaLinda,CA,April811,2002.3SupportedbyresearchgrantsHL34594,HL60712,andHL35464fromtheNationalInstitutesofHealth.FBHwaspartlysupportedbyanEstablishedIn...
医源资料库;在线期刊;美国临床营养学杂志;2003年78卷第3期