ThesurvivalkinasesAktandPimaspotentialpharmacologicaltargets
...ne,UniversityofPennsylvania,Philadelphia,Pennsylvania,USA.AbstractTheAktandPimkinasesarecytoplasmicserine/threoninekinasesthatcontrolprogrammedcelldeathbyphosphorylatingsubstratesthatregulatebothapoptosisandcellularmetabolism.ThePI3K-dependentactivationoftheAktkinasesandtheJAK/STAT–dependentinduct...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期ComparisonofTwoProbesforTestingSusceptibilitiesofPathogenicYeaststoVoriconazole,Itraconazole,andCaspofunginbyFlowCytometry
...rationsofeachantifungalagent,followedbystainingwithtwofluorescentprobes:propidiumiodide(PI)andFUN-1.FUN-1wasabletoidentifythesusceptibilitypatternsoftheassayedstrainstothethreeagentsafter1h.PIpenetratedamaximumof50%ofthecellstreatedwithPI,atthehighestconcentrationofcaspofungin,16μg/ml,after6hofincu...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期ASingleAminoAcidAlterationinCytoplasmicDomainDeterminesIL-2PromoterActivationbyLigationofCD28butNotInducibleCostimulator(ICOS)
...theCD28cytoplasmicdomainisaknownbindingsiteforphosphatidylinositol3-kinase(PI3-K)andGrb2.ICOSpossessestheYMFMmotifinthecorrespondingregionofCD28thatbindsPI3-KbutnotGrb2.WepostulatedthatthereasonthatICOSdoesnothavetheabilitytoinduceIL-2productionisbecauseitfailstorecruitGrb2.Toverifythishypothesis,we...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第2期ASingleAminoAcidAlterationinCytoplasmicDomainDeterminesIL-2PromoterActivationbyLigationofCD28butNotInducibleCostimulator(ICOS)
...theCD28cytoplasmicdomainisaknownbindingsiteforphosphatidylinositol3-kinase(PI3-K)andGrb2.ICOSpossessestheYMFMmotifinthecorrespondingregionofCD28thatbindsPI3-KbutnotGrb2.WepostulatedthatthereasonthatICOSdoesnothavetheabilitytoinduceIL-2productionisbecauseitfailstorecruitGrb2.Toverifythishypothesis,we...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第2期动物研究所在治疗禽流感方面取得突破性进展
...plasmids(http://www.sciencenews.org/index/generic/activity/view/id/31576/title/Tripping_up_avian_flu)”。该项研究是在国家自然科学基金项目、863项目以及中美国际合作项目(IOZ/CAS-USDAJointProject)的资助下完成的。当前,由于治疗禽流感的技术和方...
医药经济;生物技术;技术要闻FocalAdhesionKinaseandProteinKinaseBCooperatetoSuppressDoxorubicin-InducedApoptosisofBreastTumorCells
...icin-inducedactivationofPKB.Inaddition,inhibitionofphosphatidylinositide-3(PI-3)kinasewithwortmannininhibitedtheactivationofPKBbydoxorubicin.Bothwortmanninandtransientoverexpressionoftheduallipid/proteinphosphataseandtensinhomologdeletedonchromosome10enhanceddoxorubicin-inducedcelldeath.Altogether,t...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期AngiotensinII–InducedInsulinResistanceandProteinTyrosinePhosphatases
...teins,11includingJAK2,STAT1,STAT3,PLC-,Grb2,andphosphatidylinositol3kinase(PI3K).Asthesesignalingmoleculesassembleandbecomeactivated(ordisplayincreasedsusceptibilityforphosphorylation),adistinctsignalingcascadeistriggered.TyrosinephosphorylationactivatesJAK2,whichphosphorylatesSTATproteinsresultingi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第11期PDZinteractionsandproximaltubularphosphatereabsorption
【摘要】Inadults,theextentofrenalreabsorptionofPiandconsequentlytheextentofurinaryexcretionofphosphatearetoalargeextentdeterminedbytheabundanceoftheNa-PicotransporterNaPi-IIa(SLC34A1).Localizationofthiscotransporterisrestrictedtotheapicalmembraneofproximaltubularcells,anditsabundanceiscontrolled...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第11期Variationinnewbornsizeaccordingtopregnancyweightchangebytrimester
...nCMargellos1FromtheDepartmentofPublicHealthNutrition(JEBandMAM),DivisionofEpidemiology(JEB,MAM,DRJ,andHCM),SchoolofPublicHealth,UniversityofMinnesota,Minneapolis.2SupportedbygrantHD19724fromtheNationalInstituteofChildHealthandHumanDevelopment,NationalInstitutesofHealth,andbygrantMCJ009118fromtheMate...
医源资料库;在线期刊;美国临床营养学杂志;2002年76卷第1期CalcineurinNFATCouplingParticipatesinPathologicalbutnotPhysiological,CardiacHypertrophy
...P.,J.D.M.)andCardiology(F.J.,T.R.K.),DepartmentofPediatrics,Children’sHospitalMedicalCenter,Cincinnati,Ohio.: AbstractTopAbstractIntroductionMaterialsandMethodsResultsDiscussionReferencesCalcineurin(PP2B)isacalcium/calmodulin-activated,serine-threoninephosphatasethattransmitssignalstothenuc...
医源资料库;在线期刊;循环研究杂志;2004年第94卷第1期