天人菊内酯Gaillardin
...化学名称]Gaillardin[分子式][分子量][物理性质]NMR(CDCL3):4.70(q,C-2H),8.74(s,C-4CH3),5.50(m,C-8H),4.07(br,s,C-9H),8.18(br,s,C-10H),3.79,4.47(d(3),C-13H),7.92(s,C-2OAc);UV:209(15500)[成分分类][药理作用]抗肿瘤(人体鼻咽癌)等,治疗阿米巴痢疾,阴道滴虫[毒...
药品天地;专业药学;中药大全;中草药有效成分InvivositesandcellularmechanismsofTregcell–mediatedsuppression
...tivationordifferentiationistargetedbyTregcellsremainunknown.Furthermore,arequirementfordirecteffectorTcell–Tregcellcontactinvivohasnotbeenascertained.Varyinganswerstotheseimportantquestionshavebeenprovidedbyseveralnewstudies.Duringthedecadesincetheirdiscovery,Tregcellshavebecomemajorculpritsforimm...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期热式气体流量计在曝气控制中的应用
...量成一定的对应关系。其关系如公式(1)所示:ρυ=K(Q/△T)1.67…………………(公式1)式中ρ——流体的密度,Kg/m3;υ——流体的流速,m/h;K——标定的系数;Q——热流量,J/h;△T——温差,℃。2、技术特点(1)直接气体...
药品天地;专业药学;实验技术;色谱技术;仪器介绍与操作DepartmentofMicrobiologyandImmunology,UniversityofMichiganMedicalSchool,AnnArbor,MI48109
...teredbysomatichypermutation(SHM;1),whichcausesamillion-foldincreaseinthefrequencyofpointmutationsoftheIg-variableregiongenes(2)andrareinsertionsanddeletions(3).CurrentparadigmsteachthatindividualclonesthencompeteforantigeninaDarwinianfashion,resultingintheclonalselectionofBcellsharboringreceptorsoft...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第9期DetectionofHumanInfluenzaAVirusesbyLoop-MediatedIsothermalAmplification
DepartmentofMicrobiology,UniversityofHongKongDepartmentofMicrobiology,QueenMaryHospital,HongKongABSTRACTHerewedescribetheuseoftheloop-mediatedisothermalamplification(LAMP)methodtodetecthumaninfluenzaviruses(H1toH3).Ourresultswerecorrelated100%withresultsdeducedfromroutineclinicaldiagnostictests.Inad...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期TcelllineagechoiceanddifferentiationintheabsenceoftheRNaseIIIenzymeDicer
...of-expressingthymocyteswerenotaffected.Indevelopingthymocytes,Dicerwasnotrequiredforthemaintenanceoftranscriptionalsilencingatpericentromericsatellitesequences(constitutiveheterochromatin),themaintenanceofDNAmethylationandXchromosomeinactivationinfemalecells(facultativeheterochromatin),andthestables...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第9期Inheriteddisordersofvoltage-gatedsodiumchannels
...tionexhibitedbymutantNaVChsassociatedwithhyperkalemicperiodicparalysis,longQTsyndrome,andinheritedepilepsy.Thedefectiscausedbyincompleteclosureoftheinactivationgate(leftpanel)resultinginanincreasedlevelofpersistentcurrent(rightpanel,redtrace)ascomparedwithNaVChswithnormalinactivation(blacktrace).SCN...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第8期Functionalrolesofcationicaminoacidresiduesinthesodium-dicarboxylatecotransporter3(NaDC-3)fromwinterflounder
...llinwardcurrents.WhenK114wasreplacedbyarginine,glutamicacid(E),orglutamine(Q),allmutantswereexpressedatthecellsurface.In[14C]succinateuptakeandTEVCexperimentsperformedsimultaneouslyonthesameoocytes,uptakewassimilartoorhigherthanWT,whereassuccinate-inducedcurrentswereeithercomparable(K114R)to,orconsi...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第12期替罗非班应用于不稳定型心绞痛和非Q波心肌梗死的安全性及有效性评价
【摘要】目的评价替罗非班在冠心病不稳定型心绞痛和非Q波心肌梗死中与肝素和阿司匹林合用的安全性和有效性。方法为开放性国际多中心协作研究,我院共入选20例患者。结果20例患者中男14例,女6例,平均年龄(53.2±7.3)岁...
医源资料库;在线期刊;中华现代临床医学杂志;2006年第4卷第2期Thec-FLIP–NH2terminus(p22-FLIP)inducesNF-Bactivation
...ers:RelA,RelB,c-Rel,p50/NF-B1,andp52/NF-B2(16).Inmostcells,theNF-BdimerissequesteredinthecytosolbyinhibitorsoftheBprotein(IB),anditsnucleartranslocationcanbeinducedbyawidevarietyofstimuli(16).ThesestimulitriggeractivationoftheIBkinase(IKK)complex,whichconsistsoftwocatalyticsubunits,IKKandIKK,aswella...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第5期