CriticalRoleoftheCarboxylTerminusofProline-richTyrosineKinase(Pyk2)intheActivationofHumanNeutrophilsbyTumorNecrosisFactorSeparationofSig
...cologicinhibitors(Fuortes,M.,M.Melchior,H.Han,G.J.Lyon,andC.Nathan.1999.J.Clin.Invest.104:327–335)thatproline-richtyrosinekinase(Pyk2)playsacriticalroleintheactivationofadherenthumanneutrophils,andallowedananalysisofindividualPyk2domainsnotpossiblewithchemicalinhibitors.Actingasadominantnegative,t...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第1期胫
胫(jìng竞) 解剖结构名。见《灵枢·经脉》、《素问·脉要精微论》等篇。 ①泛指小腿部。 ②指胫骨。详该条。作者:佚名
医源资料库;中医词典;字母J病因病机·血病
...产时出血过多。注释[1]充和:旺盛,流畅。[2]发生长(zhǎng掌)养:生长,奉养。[3]劳:过度疲劳。[4]太阳:太阳穴部位。作者:聂天祥
医源资料库;医源图书馆;中医现代论著;中医眼科备读;卷一 目论语摘Lossoftheproapoptoticprotein,Bim,breaksBcellanergy
1HowardHughesMedicalInstituteandIntegratedDepartmentofImmunology,NationalJewishMedicalandResearchCenter,2DepartmentofImmunology,3DepartmentofMedicine,4DepartmentofPharmacology,and5DepartmentofBiochemistryandMolecularGenetics,UniversityofColoradoHealthSciencesCenter,Denver,CO80206AlthoughBcellsthatre...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期EriocalyxinBInhibitsNuclearFactor-BActivationbyInterferingwiththeBindingofBothp65andp50totheResponseElementinaNoncompetitiveManner
...atmentofcancer,inflammatory,andautoimmunediseases.Here,wedescribeapotentNF-Binhibitor,eriocalyxinB(Eri-B),anent-kauranoidisolatedfromIsodoneriocalyx,ananti-inflammatoryremedy.Thepresenceoftwo,-unsaturatedketonesgivethiscompoundtheuniquenessamongtheent-kauranoidstested.Eri-BinhibitedtheNF-Btranscript...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第12期SilentMyocardialIschemiainPatientsWithSymptomaticIntracranialAtherosclerosis
...edbyBristol-Myers-Squibb.ThisstudywaspartiallyfundedbygrantsfromtheRedesTemáticasdeInvestigaciónCooperativa,InstitutoCarlosIII(RedC03/01,RECAVA;RedC03/06,RedCIEN).ReferencesHartmannA,RundekT,MastH,PaikMC,Boden-AlbalaB,MohrJP,SaccoRL.Mortalityandcausesofdeathafterfirstischemicstroke.TheNorthernManh...
医源资料库;在线期刊;中风学杂志;2005年第36卷第6期ProteinKinaseC(PKC)RegulatesOcularInflammationandApoptosisinEndotoxin-InducedUveitis(EIU)
...ours,lipopolysaccharide-stimulatedmacrophagesproducedtumornecrosisfactor-(TNF-)withnuclearfactorB(NF-B)/p65expression.TreatmentledtoabsenceofNF-B/p65expressionandlowlevelsofTNF-,suggestingacceleratedinactivationofmacrophages.At24hoursafterlipopolysaccharidestimulation,nuclearNF-B/p65decreasedandnucl...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第4期NF-B–inducingkinasecontrolslymphocyteandosteoclastactivitiesininflammatoryarthritis
...peripherallymphnodes,defectiveBandTcells,andimpairedreceptoractivatorofNF-Bligand–stimulatedosteoclastogenesis.WeinvestigatedtheroleofNIKinmurinemodelsofinflammatoryarthritisusingNik–/–mice.Theserumtransferarthritismodelisinitiatedbypreformedantibodiesandrequiredonlyintactneutrophilandcompleme...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期TLRsandNODsmRNAexpressionpatterninhealthymouseeye
...ransplantationandbythepresenceofimmunosuppressors.Thismeansthatintraocularinflammation,whichcouldinterferewiththetransparencyneededtopreservethevision,isselflimited.Theimmuneprivilegeisinparttheresultofwhathasbeencalledanteriorchamberimmunedeviation(ACAID).1Ithasbeendemonstratedthattheaqueoushumourc...
医源资料库;在线期刊;英国眼科学杂志;2005年第89卷第7期ExpressionofCOX-2inplatelet-monocyteinteractionsoccursviacombinatorialregulationinvolvingadhesionandcytokinesignaling
...in/PSGL-1engagementandIL-1?signalinginCOX-2expressionwerefurtherexaminedusingU937monocyticleukocytes.IncubationofactivatedplateletswithU937cellstriggeredarapidinductionofCOX-2mRNAexpression(Figure6A).Incontrasttowhatweobservedwithprimarymonocytes(Figure2A),asecondphaseofCOX-2mRNAaccumulationwasnotap...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期