IdentificationofClinicallyRelevantViridansStreptococcibyanOligonucleotideArray
...pecieswereStreptococcusanginosus,S.constellatus,S.gordonii,S.intermedius,S.mitis,S.mutans,S.oralis,S.parasanguinis,S.salivarius,S.sanguinis,andS.uberis.ThemethodconsistedofPCRamplificationoftheITSregionsbyusingapairofuniversalprimers,followedbyhybridizationofthedigoxigenin-labeledPCRproductstoapanel...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期Effectsofisoprostaneontubuloglomerularfeedback:rolesofTPreceptors,NOS,andsaltintake
...flowpressure(PSF;anindexofglomerularcapillarypressure)duringloopofHenle(LH)microperfusionofartificialtubularfluid(ATF)at40nl/min.Microperfusionof8-Iso(104M)intotheefferentarteriole(EA)enhancedTGFresponsesby20±3%(P<0.01).TGFresponseto8-Isowasindependentofdietarysalt[TGF%,lowsalt(LS):21±5%;normalsal...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第4期Effectofzincsupplementationongrowthandbodycompositioninchildrenwithsicklecelldisease
...handdelayedmaturationinchildrenwithsicklecelldisease(SCD)maybedue,inpart,tomildzincdeficiency.Objective:TheobjectivewastodeterminetheeffectsofzincsupplementationongrowthandbodycompositioninchildrenwithSCD.Design:Forty-twoprepubertalchildren(20girlsand22boys)aged410ywithSCD-SSwererandomlyassign...
医源资料库;在线期刊;美国临床营养学杂志;2002年75卷第2期InhibitionofTumorNecrosisFactor-throughSelectiveBlockadeofPre-mRNASplicingbyShikonin
...thePKRpathwayandrevealthatregulationofTNF-pre-mRNAsplicingmayconstituteapromisingtargetforfutureanti-inflammatoryapplication.Normalimmunefunctionismaintainedbyanelaboratebalancebetweentheactivitiesofpro-andanti-inflammatorycytokines.Oneofthemostimportantpro-inflammatorycytokines,TNF-,playsapivotalro...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期NovelMechanismandRoleofAngiotensinII–InducedVascularEndothelialInjuryinHypertensiveDiastolicHeartFailure
...ndroleofangiotensinII–inducedvascularendothelialinjuryisunclear.Weexaminedthemolecularmechanismofangiotensin(AII)-inducedvascularendothelialinjuryanditssignificanceforhypertensivediastolicheartfailure.MethodsandResults—WecomparedtheeffectofvalsartanandamlodipineonDahlsalt-sensitivehypert...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第12期EnhancedImmuneSystemActivationandArterialInflammationAcceleratesAtherosclerosisinLupus-ProneMice
...摘要】Objective-Prematureatherosclerosisisacharacteristicfeatureofsystemiclupuserythematosus,aprototypicautoimmunedisease.Theprinciplecellularandmolecularmechanismswhichunderliesuchacceleratedatherosclerosisareindeterminate.MethodsandResults-Thepathophysiologyoflupus-mediatedatherogenesiswasevalu...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第7期(6R)-5,6,7,8-Tetrahydro-L-BiopterinandItsStereoisomerPreventIschemiaReperfusionInjuryinHumanForearm
....Itsstereo-isomer6S-5,6,7,8-tetrahydro-L-biopterin(6S-BH4)andstructurallysimilarpterin6R,S-5,6,7,8-tetrahydro-D-neopterin(NH4)arealsoantioxidantsbuthavenocofactorfunction.Whenendothelialnitricoxidesynthaseis6R-BH4–deplete,itsynthesizessuperoxideratherthannitricoxide.Reducednitricoxidebioavaila...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第6期DeletionofRD1fromMycobacteriumtuberculosisMimicsBacilleCalmette-GuérinAttenuation
...sof1Pediatricsand2Pathobiology,UniversityofWashington,Seattle;3DepartmentofMicrobiologyandImmunology,McGillUniversity,Montreal,Quebec,CanadaReceived1July2002;revised12September2002;electronicallypublished2December2002.Thetuberculosis(TB)vaccinebacilleCalmette-Guérin(BCG)isaliveattenuatedorganism,bu...
医源资料库;在线期刊;传染病学杂志;2003年第187卷第1期APolymorphismintheProtease-LikeDomainofApolipoprotein(a)IsAssociatedWithSevereCoronaryArteryDisease
...tidepolymorphisms(SNPs)inStudy1(781cases,603controls)andidentified302SNPsnominallyassociatedwithsevereCAD.Testingthese302SNPsinStudy2(471cases,298controls),wefound5(inLPA,CALM1,HAP1,AP3B1,andABCG2)werenominallyassociatedwithsevereCADandhadthesameriskallelesinbothstudies.Wethentestedthese5SNPsinStudy...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第9期Interleukin-ßandSignalingofInterleukin-inVascularWallandCirculatingCellsModulatestheExtentofNeointimaFormationinMice
...IL)-1isanimportantmediatorofinflammationandcardiovasculardisease.Here,weexaminedtheroleofIL-1inarterialneointimaformation.Carotidarteryneointimawasinducedbyligation,andarterieswereharvested4weeksafterinjury.Theneointima/mediaofmicedeficientintheIL-1signalingreceptor(IL-1R1C/C)wassignificantlyreduced...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期