Modelofnonalcoholicsteatohepatitis
...orelucidatingitstreatment.KeyWords:ModelofnonalcoholicsteatohepatitismicrosomescytochromeP4502E1tumornecrosisfactorcollagen4-hydroxynonenalinsulinresistancehigh-fatdietdietaryrestrictionoxidativestressmitochondriaINTRODUCTIONObesityanddiabe...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第3期AngiotensinIIType1aReceptorIsInvolvedinCellInfiltration,CytokineProduction,andNeovascularizationinInfarctedMyocardium
...weinducedmyocardialinfarctioninangiotensinIItype1areceptor(AT1)knockout(KO)mice.MethodsandResults—Thereweremorevesselsintheborderzoneofinfarctedheartsofwild-type(WT)miceandAT1KOmiceat14daysafteroperation,comparedwithintheleftventricleofsham-operatedmice,andthenumberwaslargerinWTmicethaninAT1KOmice...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第4期ProgesteroneAntagonizestheVasoprotectiveEffectofEstrogenonAntioxidantEnzymeExpressionandFunction
...reinvestigatedinculturedvascularsmoothmusclecells(VSMCs)andvasculartissueofmice.Progesteronetime-andconcentration-dependentlydownregulatedextracellularsuperoxidedismutase(ecSOD)andmanganesesuperoxidedismutase(MnSOD)expressionandenzymeactivityandreversed17-estradioleCinducedoverexpressionofecSODandMn...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第11期MacrophageApolipoproteinEReducesAtherosclerosisandPreventsPrematureDeathinApolipoproteinEandScavengerReceptor-ClassBIDouble-KnockoutMice
【摘要】Objective-Micenullforbothapolipoprotein(apo)Eandscavengerreceptor(SR)-BI(DKO)developseverehypercholesterolemia,occlusivecoronaryatherosclerosis,myocardialinfarction,andprematuredeath.ThecurrentstudyexaminestheabilityofmacrophageapoEtoimprovethedyslipidemia,reduceatherosclerosis,andrescue...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第1期DietaryFat–InducedAlterationsinAtherosclerosisAreAbolishedbyACAT2-DeficiencyinApoB100Only,LDLr–/–Mice
...nACAT2activityisremovedbygenedeletion,hepaticCEsynthesisandsecretionwouldbeminimaland,asaresult,dietaryfat-relateddifferencesinatherosclerosiswouldbeeliminated.MethodsandResults—GroupsoffemaleapoB100only,LDLr–/–micewithandwithoutACAT2werefeddietsenrichedineither-3or-6polyunsaturate...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第6期OverexpressionofCarcinomaandEmbryonicCytotrophoblastCell-SpecificMig-InducesInvasionandVessel-LikeStructureFormation
【摘要】Molecularrequirementsforcarcinomacellinteractionswiththemicroenvironmentarecriticalfordiseaseprogressionbutarepoorlyunderstood.Integrinvß5,whichsensestheextracellularmatrix,isimportantforcarcinomacelldisseminationinvivo.vß5signalinginducesMig-7,anovelhumangeneproductthatisapp...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期Edentulismandnutritionalstatusinabiracialsampleofwell-functioning,community-dwellingelderly:theHealth,Aging,andBodyCompositionStudy
...mandnutritionalstatusisnotcompletelyunderstood.Objective:Thepresentstudyexaminedwhetheredentulismisassociatedwithnutritionalstatusandwhetherthereisaninteractionbetweenraceandedentulismonnutritionalstatusamongwell-functioning,community-dwellingelderly.Design:Thestudycohortincluded3075elderlyaged70...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第2期Ecto-5‘-nucleotidase(cd73)-dependentand-independentgenerationofadenosineparticipatesinthemediationoftubuloglomerularfeedbackinvivo
...ase(cd73)inTGF,inregulationofGFR,andintubularreabsorption,renalclearanceandmicropuntureexperimentswereperformedincd73wild-type(cd73+/+)andknockoutmice(cd73-/-).Thecd73-/-micepresentednormalmeanarterialbloodpressure,butmodestlylowerwholekidneyandsinglenephronGFR(SNGFR).FractionalreabsorptionofNa+andK...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期Cortistatin,anewantiinflammatorypeptidewiththerapeuticeffectonlethalendotoxemia
...inflammatorymediatorsanditstherapeuticactioninvariousmurinemodelsofendotoxemia.Cortistatindown-regulatedtheproductionofinflammatorymediatorsbyendotoxin-activatedmacrophages.Theadministrationofcortistatinprotectedagainstlethalityaftercecalligationandpuncture,orinjectionofbacterialendotoxinorEscherich...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期VascularEndothelialGrowthFactor-AMediatesUltravioletB-InducedImpairmentofLymphaticVesselFunction
...n.WereportherethatbothacuteandchronicUVBirradiationofmurineskinresultsinprominentenlargementoflymphaticvessels.Surprisingly,theseenlargedlymphaticvesselswerefunctionallyimpairedandhyperpermeable,asdetectedbyintravitallymphangiography.Theexpressionlevelsofvascularendothelialgrowthfactor(VEGF)-Abutnot...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第10期