SpeciesSelectivityofaNicotinicAcetylcholineReceptorAgonistIsConferredbyTwoAdjacentExtracellular4AminoAcidsthatAreImplicatedintheCoupling
【关键词】SpeciesSelectivity5-(Trifluoromethyl)-6-(1-methyl-azepan-4-yl)methyl-1H-quinolin-2-one(TMAQ)isanovelnicotinicacetylcholinereceptor(nAChR)agonistwithstrongselectivityfor4-containingreceptors.TMAQalsoexhibitsremarkablespeciesselectivity,beingapotentagonistofnAChRscontainingthehuman4subu...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第2期固有免疫及其相关细胞信号转导研究
北京大学生命科学学院蒋争凡课题组的论文“PCBP2mediatesdegradationoftheadaptorMAVSviatheHECTubiquitinligaseAIP4”于11月1日在《自然—免疫学》(NatureImmunology)发表。该项工作发现并证明细胞存在一条由PCBP2-AIP4介导的蛋白质降解途径,特异...
行业资讯;临床快报;免疫系统维吾尔族人群抗原处理相关转运体(TAP)基因多态性及与类风湿关节炎的相关性
...健康维吾尔族人群TAP1-333位和637位等位基因基因型分别以I和D为主,表现型主要为II和DD,有1A~1D4个亚型,以1A和1B为主;TAP2-379、565、651、665、687等位基因型分别以V-A-R-T-Q为主,表现型以VV-AT-RR-TT-QQ为主,有2A~2H共8个亚型,以2A和2...
合作平台;医学论文;临床医学与专科论文;检验医学十一五科技支撑计划“疫苗关键生产技术”课题申报指南
...,大幅度缩小与发达国家之间的差距。通过项目实施,提高紧缺疫苗大品种的产量,提高优势企业疫苗的质量,为疫苗行业的进一步集约化提供科技支撑;大力推动国际化进程,促进我国疫苗产品出口,提高我国疫苗产品在国际...
医学教育;科教新闻MolecularIdentificationofAdenovirusesinClinicalSamplesbyAnalyzingaPartialHexonGenomicRegion
ServiciodeVirologíaServiciodeMicrobiologíaDiagnostica,CentroNacionaldeMicrobiología,ISCIII,Madrid,SpainTheJeromeL.andDawnGreeneInfectiousDiseaseLaboratory,MailmanSchoolofPublicHealth,ColumbiaUniversity,NewYork,NewYorkCátedradeVirología,FacultaddeFarmaciayBioquímica,UniversidaddeBuenosAires,Bue...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期EpidemiologyandOutcomeofNosocomialandCommunity-OnsetBloodstreamInfection
DivisionofInfectiousDiseases,DepartmentofInternalMedicine,1DivisionofMedicalMicrobiology,DepartmentofPathology,RoyJ.andLucilleA.CarverUniversityofIowaCollegeofMedicine,IowaCity,Iowa,2DivisionofMedicalMicrobiology,DepartmentofPathology,LaheyClinic,Burlington,Massachusetts3Received20December2002/Retur...
医源资料库;在线期刊;微生物临床杂志;2003年第41卷第8期MultiplexPCRAssayforRapidIdentificationofOculopathogenicAdenovirusesbyAmplificationoftheFiberandHexonGenes
InfectiousDiseaseSurveillanceCenter,NationalInstituteofInfectiousDiseasesDepartmentofDevelopmentalMedicalSciences,GraduateSchoolofMedicine,TheUniversityofTokyo,Tokyo,JapanABSTRACTEyeinfectionscausedbyadenovirus(Ad)oftenresultinnosocomialinfectionsandcommunityepidemicswithsignificantratesofmorbidity....
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第3期DistributionoftheBeijingFamilyGenotypesofMycobacteriumtuberculosisinTaiwan
ReferenceLaboratoryofMycobacteriology,DivisionofLaboratoryResearchandDevelopment,CenterforDiseaseControl,DepartmentofHealth,Taipei,TaiwanInternationalUnionAgainstTuberculosisandLungDisease,Paris,FranceABSTRACTToinvestigatethedistributionoftheBeijingfamilygenotypesofMycobacteriumtuberculosisinTaiwan,...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期基因密码子扩展模拟光合作用
...秒瞬态光谱测量到电子转移发生在皮秒范围(接近光系统I中最快的电子转移步骤)。利用晶体结构研究测量了发色团到电子受体之间的距离,揭示了该电子转移过程是距离依赖的过程(与光系统I一致)。此外,该电子受体非天...
医药经济;生物技术;技术要闻ActivationoftheAngiotensinIIType1ReceptorLeadstoMovementoftheSixthTransmembraneDomain:AnalysisbytheSubstitutedCysteineAccessibilityMetho
【关键词】ActivationTheroleoftransmembranedomainsix(TMD6)oftheangiotensinIItype1receptor,whichispredictedtoundergoconformationalchangesafteragonistbinding,wasinvestigatedusingthesubstituted-cysteineaccessibilitymethod.EachresidueintheLys240-Leu265fragmentwasmutated,oneatatime,toacysteine.Theres...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期