QuantitativeTraitLociforApolipoproteinB,Cholesterol,andTriglyceridesinFamilialCombinedHyperlipidemiaPedigrees
...otbethemostusefulphenotypeforfindingthecomplementofpredisposinggenes,andthequantitativetraitsusedtodefinethedisordercanprovideimportantinformation.Thisisareportofaquantitativetraitloci(QTL)analysisofFCHL.MethodsandResults—Afullgenomescanof377multi-allelicmarkersgenotypedat10centimorgan(cM)interval...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第10期VSIG4,aB7family–relatedprotein,isanegativeregulatorofTcellactivation
...tforfullTcellactivation,butadditionalsignalsfromcostimulatorymoleculesarerequired(1–4).ThemostprominentcostimulatorymoleculeexpressedonTcellsisCD28,interactingwiththeB7familymembersCD80andCD86(5,6).EngagementofCD28facilitatesTcellactivationbyenhancingTCR-mediatedsignalingandreducingthenumberofTCRs...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期IdentificationofEssentialHistidineandCysteineResiduesoftheH+/OrganicCationAntiporterMultidrugandToxinExtrusion(MATE)
...ffectswereobserved.TheseresultssuggestthathistidineandcysteineresiduesarerequiredforMATE1tofunctionandthatcysteineresiduesmayserveassubstrate-recognitionsites.Proximaltubulesplayimportantrolesintherenaleliminationofdrugs.Cationicdrugsaresecretedfrombloodtourinebythecombinedeffortsoftwodistinctclasse...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期UseofRNAInterferencetoPreventLethalMurineWestNileVirusInfection
...rica[1,2].WestNilevirusismaintainedinanenzooticcyclethatincludesbirdsandmosquitoes.SincethefirstoutbreakintheNewYorkCityareain1999,WestNilevirushasspreadthroughoutmuchofNorthAmerica,causingsignificantmorbidityandmortality[3].EffectivedrugsorvaccinestopreventWestNilevirusinfectionhavenotyetbeenapprov...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第7期EarlyG2/Mcheckpointfailureasamolecularmechanismunderlyingetoposide-inducedchromosomalaberrations
...phaseATM-deficientfibroblastswith1(upperpanel)and3(lowerpanel)centromeric11q23signals.(E)ProportionofmetaphaseandpostmitoticG1phasecellswithgain(red)andloss(blue)ofCH11C(left)orcentromeric11q23(right)probesignals.n250foreach.*Oddsratio(OR)foretoposidetreatment.**P=0.77andP0.0001,differencesinORbetwe...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第8期安痛藤化学成分的研究
...in—Elmer公司)、Mercuryplus400MHz核磁共振仪(美国varian公司)、Q—TofmicoYA019质谱仪(英国质谱公司),硅胶均为青岛海洋化工厂产品,柱层析用聚酰胺为浙江省台州市路桥四甲生化塑料厂,所用试剂均为分析纯。安痛藤采于江西赣南地区...
药品天地;专业药学;实验技术;色谱技术;色谱分析实例TheScurfymutationofFoxP3inthethymusstromaleadstodefectivethymopoiesis
...lopmentofregulatoryTcells.Inaddition,developmentoftheScurfydiseasealsomayrequiremutationofthegeneinnonhematopoieticcells.TheTcell–extrinsicfunctionofFoxP3hasnotbeencharacterized.HereweshowthattheFoxP3sfmutationleadstodefectivethymopoiesis,whichiscausedbyinactivationofFoxP3inthethymicstromalcells.F...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第8期MultipleorganinfectionandthepathogenesisofSARS
...osedSARScasesalsowereanalyzedretrospectively.SARSviralparticlesandgenomicsequenceweredetectedinalargenumberofcirculatinglymphocytes,monocytes,andlymphoidtissues,aswellasintheepithelialcellsoftherespiratorytract,themucosaoftheintestine,theepitheliumoftherenaldistaltubules,theneuronsofthebrain,andmacr...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第3期ClonalAnalysisofStaphylococcusepidermidisIsolatesCarryingorLackingBiofilm-MediatingGenesbyMultilocusSequenceTyping
...ofilm-negativestrainsthroughhorizontalgenetransfer.Inthisstudy,multilocussequencetyping(MLST)wasemployedfortheclonalanalysisof118S.epidermidisica-positiveand-negativestrains.MLSTrevealedthatthemajorityofica-positiveand-negativestrainswerecloselyrelatedandformedasingleclonalcomplex.Withinthiscomplexo...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期DiminishedReplicativeFitnessofPrimaryHumanImmunodeficiencyVirusType1IsolatesHarboringtheK65RMutation
...itethewiderusageofabacavirandTDF,theoccurrenceoftheK65Rmutationremainsinfrequentintreatment-experiencedpatients(2to4%)(1,5).ThelowincidenceofvirusesharboringtheK65Rmutationamongantiretroviral-treatedpatientssupportsthehypothesisofadefectinthereplicativefitnessoftheseviralstrains(10).Forexample,sever...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第3期