14-3-3蛋白
...的高度催化活性中发挥重要作用。 哺乳动物细胞生长因子刺激Raf-1和Ras结合后,14-3-3介导磷酸化的Raf-1移向胞膜并在胞膜上活化;而Ras作为Raf-1活性刺激因子亦不能充分活化Raf-1,需要14-3-3、Hsp90和KSR等参与。14-3-3与Raf-1的多个...
医源资料库;在线期刊;中华医学研究杂志;2006年第6卷第10期EffectsofValproicAcidDerivativesonInositolTrisphosphateDepletion,Teratogenicity,GlycogenSynthaseKinase-3Inhibition,andViralReplication:AScre
...theimportanceofthisdisorder—judgedbytheWorldHealthOrganizationtoberankedsixthhighestinyearsoflifelosttodeathorsuicide(MurrayandLopez,1996)—itisessentialtodevelopnewandmoreeffectivetreatments.Thefirsttheoryofmooddisorderdrugaction(Berridgeetal.,1989),the“inositoldepletiontheory“,proposedthatl...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第5期Whatisknownaboutthesafetyofmultivitamin-multimineralsupplementsforthegenerallyhealthypopulation?Theoreticalbasisforharm
...tisconsumedinaconcentratedform,thatis,asasupplement,orwithinanormalfoodmatrix.Large,singledosesofmanynutrientscanresultingastrointestinaleffects,forexample,vitaminCinlargedosesisassociatedwithdiarrhea,asismagnesium,whereasironisgenerallyassociatedwithconstipationbutalsowithnausea,vomiting,andepigast...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第1期广西大学生性病艾滋病相关知识态度行为调查
...预防控制中心,530011【基金项目】世界银行贷款广西卫生IX项目资助。作者:徐永芳,周吉,莫秀娟,朱建靖,梁红慧,周芳华,李萍
医源资料库;在线期刊;中国学校卫生;2007年第27卷第11期CalpainMediatestheDioxin-InducedActivationandDown-RegulationoftheArylHydrocarbonReceptor
...rocarbonReceptorThearylhydrocarbonreceptor(AhR)isaligand-activatedbasic-helix-loop-helixtranscriptionfactorthatbindspolyaromatichydrocarbons(PAH),suchas2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD),andmediatestheirtoxicity.BindingofPAHtoAhRinthecytoplasmtriggersapoorlydefinedtransformationstepoftherecep...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期ANovelClassofFusionPolypeptidesInhibitsExocytosis
...nolpyruvate,50Uoflactatedehydrogenase,and50Uofpyruvatekinase)wasaddedtothemixture,followedby10eofNADH(2mg/mlin1%sodiumbicarbonate).Themixturewasincubatedfor10minat22°C,andtheabsorbancewasmeasuredat340nm.NSFDisassemblyAssay.Analysisofthe7Sand20Scomplexeswasperformedaccordingtoprotocolspublishedprevi...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第4期阑尾类癌误诊为阑尾炎12例临床分析
...右半结肠切除术。关键词阑尾类癌误诊手术Carcinoidofappendixmisdiagnosedasappendicitis:aclinicalstudyof12casesLiBojianDepartmentofGeneralSurgery,ShundeDistrictJunanHospitalofFoshan,Guangdong528329.【Abstract】ObjectiveTosummarizethebiologicalfeature,diagnosis,thecausesformi...
资料库;在线期刊;中华现代外科学杂志;2005年第2卷第4期DualRoleforPlasminogenActivatorInhibitorTypeasSolubleandasMatricellularRegulatorofEpithelialAlveolarCellWoundHealing
...teolysisduringepithelialrepair.Inaddition,thecomplexformedbyuPAR-uPAandmatrix-boundplasminogenactivatorinhibitortype-1(PAI-1)exertsnonproteolyticrolesinvariouscelltypes.HerewepresentnewevidenceaboutthedualroleofPAI-1underkeratinocytegrowthfactorstimulationusinganinvitrorepairmodelofratalveolarepithe...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第11期第三节 肝脏的生物转化作用
...即一种氧分子发挥了两种功能,故又称混合功能氧化酶(mixedfunctionoxidase)。亦可称为羟化酶。加单氧酶系的特异性较差,可催化多种有机物质进行不同类型的氧化反应。 (1)加单氧酶系的组成 加单氧酶系由NADPH,NADPH细胞...
医源资料库;医源图书馆;教材类;生物化学与分子生物学SYBRGreenI荧光PCR检测登革热病毒基因方法的建立
...反应体系为20μl。内含:2×QuantiTectSYBRGreenIRT-PCRMasterMix10μl;上游引物、下游引物(10μmol/μL)各1μl,终浓度为015μmol/μl;QuantiTectRTMix0.12μl;模板1μl;无RNase水6.8μl。反应条件为:50℃20min(×1),95℃10min(×1),94℃15s→59...
医源资料库;在线期刊;中国热带医学杂志;2007年第7卷第10期