CardiovascularExpressionoftheMouseWNKGeneduringDevelopmentandAdulthoodRevealedbyaBACReporterAssay
...sioninE13heart(Figure2A)wassimilartothatofendogenousWNK1(Figure2B).WestainedembryocryosectionstolocatenlacZexpressionmorepreciselyintheprimitiveheart.AtE12.5,expressionwasstrongestintheoutflowtractandatrioventricularcanal(Figure2C).AtE14.5,expressionwasstrongestinthetrabeculationsoftheventricularwal...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第7期Melanomageneticsandthedevelopmentofrationaltherapeutics
...er,itwasnotuntil1806,whenRenéLaennecdescribed“lamelanose“totheFacultédeMédecineinParis,thatthediseasewascharacterizedindetailandnamed(2).GeneralpractitionerWilliamNorrissuggestedthatmelanomamaybehereditaryinan1820manuscriptdescribingafamilywithnumerousmolesandseveralfamilymemberswithmetastati...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第4期MonitoringtheActivationStateofInsulin/Insulin-LikeGrowthFactor-1HybridReceptorsUsingBioluminescenceResonanceEnergyTransfer
...nceofhybridreceptors,madeupofan-IRAchainassociatedwithan-IGF1Rchain,hasbeendemonstrated.Theseheterodimersarefoundinnormalcells,andtheyalsoseemtoplaycrucialrolesinanumberofcancers.However,theyremaindifficulttostudy,duetotheconcomitantpresenceofIRAandIGF1Rhomodimers.Usingbioluminescenceresonanceenergy...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期RecruitmentofaProstaglandinEReceptorSubtypeEP-ExpressingBoneMarrowCellsIsCrucialinWound-InducedAngiogenesis
...diumphosphatebuffer(pH7.4),dehydratedwithagradedseriesofethanolsolutions,andembeddedinparaffin.Sections(4µminthickness)werepreparedfromtheparaffin-embeddedtissueandweremountedonglassslides;afterremovalofparaffinwithxylene,theslideswerethenplacedincold(4??C)acetone.Thesectionsweresubjectedtoeit...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第10期RegulationofLysophosphatidicAcidReceptorExpressionandFunctioninHumanSynoviocytes:ImplicationsforRheumatoidArthritis?
...LPA-orOMPT-dependentsecretionofIL-8/IL-6issignificantlyincreased.Finally,wedemonstratethepresenceofATXinsynovialfluidofRApatientsandthereductionofsynovialfluid-inducedcellmotilitybyLPA1/3receptorantagonistsandATXinhibitors,whichissuggestiveofLPAproductionandLPAsubsequentbiologicaleffectsinhumanRAsyn...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期Treatmentofprotein-energymalnutritioninchronicnonmalignantdisorders
...fPEMincasesofchronicobstructivepulmonarydisease,chronicheartfailure,stroke,dementia,reha-bilitationafterhipfracture,chronicrenalfailure,rheumatoidarthritis,andmultipledisordersintheelderly.Severalmethod-ologicproblemsareassociatedwithnutritiontreatmentstudiesinchronicallyillpatients.Theseproblemsinc...
医源资料库;在线期刊;美国临床营养学杂志;2001年74卷第1期Alzheimer??sDisease-LikeTauNeuropathologyLeadstoMemoryDeficitsandLossofFunctionalSynapsesinaNovelMutatedTauTransgenicMousewithoutAnyMoto
...-------------------------------Alzheimer??sdisease(AD)isthemostcommonformofdementiaintheelderlyandischaracterizedneuropathologicallybythepresenceofintracellularneurofibrillarytangles(NFTs)andsenileplaquesinthebrainandbyamajorlossofsynapticconnections.NFTsareneuronalinclusionsofthemicrotubule-associa...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期EarlyAxonopathyPrecedingNeurofibrillaryTanglesinMutantTauTransgenicMice
...diseaseshavebeenreferredtoastauopathies1andincludesomeformsoffrontotemporaldementia,Pick??sdisease,progressivesupranuclearpalsy,corticobasaldegeneration,andAlzheimer??sdisease(AD).Severalofthesetauopathiesarecharacterizedbybothcognitiveandmotordysfunctionandwidespreadtaupathologyinbrain,brainstem,an...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期DesignofPAP-1,aSelectiveSmallMoleculeKv1.3Blocker,fortheSuppressionofEffectorMemoryTCellsinAutoimmuneDiseases
...v1.3hasbeenfurthervalidatedasatargetforthetreatmentofmultiplesclerosisbythedemonstrationthatmyelin-reactiveTcellsinthebloodfrompatientswithmultiplesclerosisarepredominantlyKv1.3higheffectormemoryTcells(Wulffetal.,2003b).Contrarytotheaforementionedpeptides,asmall-moleculeKv1.3blockerwouldhavetheadvan...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期