FreeFattyAcidImpairmentofNitricOxideProductioninEndothelialCellsIsMediatedbyIKK?
...ox359748,3259thAve,Seattle,WA98104.E-mailfkim@u.washington.eduAbstractObjective—Freefattyacids(FFA)arecommonlyelevatedindiabetesandobesityandhavebeenshowntoimpairnitricoxide(NO)productionbyendothelialcells.However,thesignalingpathwaysresponsibleforFFAimpairmentofNOproductioninendothelialcellshaven...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第5期AcyclicRetinoidInhibitsNeointimaFormationThroughRetinoicAcidReceptorBeta-InducedApoptosis
【摘要】Objectives-Acyclicretinoid(ACR)isasyntheticretinoidwithahighsafetyprofilethathasbeenpursuedwithhighexpectationsfortherapeuticuseinprevention(recurrence)andtreatmentofmalignancies.Withtheobjectiveofaddressingthetherapeuticpotentialinthecardiovasculature,namelyneointimaformation,effectsofA...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第7期DrugResistanceEvolutionofaMycobacteriumtuberculosisStrainfromaNoncompliantPatient
DipartimentodiBiologiaMolecolare,LaboratoriodiMicrobiologiaMolecolareeBiotecnologia,UniversitadiSiena,SienaDipartimentodiScienzeOdontostomatologiche,Universita‘diCagliari,CagliariDipartimentodiMalattieInfettive,ParassitarieeImmunomediate,IstitutoSuperiorediSanita,00161RomaDipartimentodiMicrobiolog...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第7期越来越凶悍的杀手
...所有发达国家关于癌症的研究都是在国家健康研究所(NationalInsti-tuteofHealth,NIH)或者国家癌症研究所(NationalCancerInsti-tute,NCI)主导进行的,这类机构的主要目的是研究癌症的病理学而不是更实用的治疗手段和药物开发,治疗...
行业资讯;临床快报;肿瘤相关N-(Carboxymethyl)lysineDepositionsinIntramyocardialBloodVesselsinHumanandRatAcuteMyocardialInfarction
【摘要】Objective-Advancedglycationendproducts(AGEs),suchasN-(carboxymethyl)lysine(CML),areimplicatedinvasculardisease.WepreviouslyreportedincreasedCMLaccumulationinsmallintramyocardialbloodvesselsindiabetespatients.Diabetespatientshaveanincreasedriskforacutemyocardialinfarction(AMI).Here,weexam...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第11期Involvementofthe90-kDaHeatShockProtein(Hsp-90)inCB2CannabinoidReceptor-MediatedCellMigration:ANewRoleofHsp-90inMigrationSignalingofaG
...InvolvementTheendocannabinoid2-arachidonoylglycerol(2-AG)enhancescellmigrationthroughtheCB2cannabinoidreceptor.Inthisstudy,usinganimmunoprecipitationandmassspectrometry-basedproteomicapproach,wefirstidentifiedthe90-kDaheatshockprotein(Hsp90),achaperoneproteinwithnovelsignalingfunctions,asaCB2-intera...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期Pulmonarycachexia,systemicinflammatoryprofile,andtheinterleukin1ß511singlenucleotidepolymorphism
RoelinkaBroekhuizen,RobertFGrimble,WMartinHowell,DennisJShale,EvaCCreutzberg,EmielFWoutersandAnnemieMSchols1FromtheDepartmentofRespiratoryMedicine,UniversityHospitalMaastricht,Netherlands(RB,EFW,andAMS);theSchoolofMedicine,UniversityofSouthampton,Southampton,UnitedKingdom(RFGandWMH);theSectionofResp...
医源资料库;在线期刊;美国临床营养学杂志;2005年82卷第5期JABDeterminestheResponseofRheumatoidArthritisSynovialFibroblaststoTumorNecrosisFactor-
【摘要】Fibroblast-likesynoviocytes(FLSs)ofpatientswithrheumatoidarthritis(RAFLSs)exhibitprosurvival,ratherthanapoptotic,responsetotumornecrosisfactor(TNF)-stimulation.Here,weshowthatJAB1isacriticalregulatoroftheTNF--mediatedanti-apo-ptosispathwaysinRAFLSs.WefoundthatknockdownofJAB1usingsmallint...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期PECAM-1InteractsWithNitricOxideSynthaseinHumanEndothelialCells
...D.,N.L.,L.L.,J.A.F.),UniversityofCaliforniaSanDiego,andtheBioengineeringInstitute(K.S.B.,H.Y.S.,J.Y.,L.A.O.,J.A.F.),LaJolla,Calif.ABSTRACTObjective—Wehavepreviouslyshownthatfluidshearstress(FSS)triggersendothelialnitricoxidesynthase(eNOS)activityinendothelialcellsandthatthemechanotransductionmecha...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第10期AcriticalroleforenhancedTGF-andEGFRexpressionintheinitiationofparathyroidhyperplasiainexperimentalkidneydisease
...henhancedexpressionofthegrowthpromotertransforminggrowthfactor-(TGF-).TGF-stimulatesgrowththroughactivationofitsreceptor,theepidermalgrowthfactorreceptor(EGFR),normallyexpressedintheparathyroidglands.BecauseenhancedcoexpressionofTGF-andEGFRcausesaggressivecellulargrowth,thesestudiesutilizedhighlyspe...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第11期