StructureandfunctionoftheplateletintegrinIIb?3
...heheteromericassociationoftheIIband?3transmembraneandcytoplasmicdomains.Thebiochemical,biophysical,andultrastructuralresultsthatsupportthisconclusionarediscussedinthisReview.Integrinsareubiquitoustransmembrane/?heterodimersthatmediatediverseprocessesrequiringcell-matrixandcell-cellinteractionssuchas...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第12期Adose-dependentrequirementfortheprolinemotifofCD28incellularandhumoralimmunityrevealedbyatargetedknockinmutant
...8haveimpairedproliferativeresponses,makelittleIL-2,andhaveincreasedsusceptibilitytoapoptosis(2–5).AlthoughtheimportanceofCD28inTcellfunctioniswellestablished,manyquestionsremainastothemechanismbywhichCD28mediatesitsbiologicaleffects.CD28ismostcriticalintheactivationofresting,naiveTcells.Furthermor...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第9期PPARregulatesadipocytecholesterolmetabolismviaoxidizedLDLreceptor1
...ls,enlargedadipocytesisolatedfromobeseanimalsorhumansdemonstrateadecreasedabilitytostoretriglycerides(4),increasedinsulinresistance(5),andincreasedsecretionofleptinandTNF-(6).Interestingly,adiposetissuefromob/obmicealsoexhibitsanincreaseincholesterolbiosynthesis(7),andhypertrophiedadipocytesfrom2obe...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第8期Trans-cyclopropanationofmycolicacidsontrehalosedimycolatesuppressesMycobacteriumtuberculosis–inducedinflammationandvirulence
...rCenter,NewYork,NewYork,USA.2HowardHughesMedicalInstitute,DepartmentofMicrobiologyandImmunology,AlbertEinsteinCollegeofMedicine,NewYork,NewYork,USA.3DivisionofInfectiousDiseases,MemorialSloan-KetteringCancerCenter,NewYork,NewYork,USA.AbstractRecentstudieshaveshownthatfinestructuralmodificationsofMyc...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期DifferentialRegulationofCathepsinSandCathepsinLinInterferon–treatedMacrophages
...tethepersistenceofhighlevelsofmaturecatLprotein,suggestingthataspecificinhibitoroftheenzymeisup-regulatedinIFN-–stimulatedperitonealMs.SimilarinhibitionofactivityisobservedindendriticcellsengineeredtooverexpresscatL.SuchenzymaticinhibitioninMsexhibitsonlypartialdependenceuponIiandtherefore,otherme...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第2期DifferentialRegulationofCathepsinSandCathepsinLinInterferon–treatedMacrophages
...tethepersistenceofhighlevelsofmaturecatLprotein,suggestingthataspecificinhibitoroftheenzymeisup-regulatedinIFN-–stimulatedperitonealMs.SimilarinhibitionofactivityisobservedindendriticcellsengineeredtooverexpresscatL.SuchenzymaticinhibitioninMsexhibitsonlypartialdependenceuponIiandtherefore,otherme...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第2期老年原发性高血压患者冠状动脉病变临床分析
...46±0.32)mm,颈动脉僵硬度为(3007.3±1022.47),均明显高于脉压40~60mmHg组(P<0.01或P<0.05)。而颈动脉扩张性为(0.12±0.08)、紧张度为(2.31±1.03),明显比脉压40~60mmHg组降低(P<0.05或P60mmHg组升高(P<0.01或P<0.05)。直线相关分析显示,颈...
医源资料库;在线期刊;中国热带医学杂志;2008年第8卷第6期RestrictedMHC–peptiderepertoirepredisposestoautoimmunity
1TheJacksonLaboratory,BarHarbor,ME046092SectionofImmunobiology,YaleUniversity,NewHaven,CT065203CancerResearchCenter,Moscow115478,RussiaMHCmoleculesassociatedwithautoimmunitypossessknownstructuralfeaturesthatlimittherepertoireofpeptidesthattheycanpresent.SuchlimitationgivesaselectiveadvantagetoTCRsth...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第1期中央角膜较厚的高眼压症者临床随访观察
【摘要】目的:探讨高眼压症者中央角膜厚度(CCT)与眼压(IOP)的关系,观察CCT在判断高眼压症者是否给予降眼压治疗中的临床价值。方法:对113例(226眼)高眼压症者进行超声角膜厚度测量和非接触眼压计(NCT)测眼压,对...
医源资料库;在线期刊;中国民康医学;2009年第21卷第13期海南黎汉族高血压人群ACE基因多态性与危险因素研究
【摘要】 目的研究海南黎汉族高血压人群ACE基因多态性及危险因素的关系。方法采用聚合酶链反应(PCR)方法,对海南黎族111例高血压患者、146例黎族正常人和海南汉族106例高血压患者、97例汉族正常人的ACE基因插入/缺失(...
医源资料库;在线期刊;中国热带医学杂志;2007年第7卷第7期