Denys-Drash综合征及其致病基因突变鉴定二例报道
...基C→A突变,造成第401位组氨酸改变为谷氨酰胺,即p.H401Q(c.1203C>A)。其中第1203位碱基C→A突变,p.H401Q(c.1203C>A),在国内外文献及突变数据库中均未见报道,属新发现的突变。可见DDS综合征WT1基因中外显子9为突变热点,并发现...
行业资讯;临床快报;遗传与基因组低剂量辐射对小鼠S180肉瘤组织EPO和VEGF表达影响
...结果E、F组与A组小鼠的瘤质量比较,差异有显著性(F=3.90,q=4.525、4.551,P<0.05)。A组肿瘤组织中EPO的阳性率与E、F组比较,差异有显著性(F=16.26,q=6.600、7.554,P<0.01)。LDR各组肿瘤组织中VEGF的阳性率与A组比较差异亦有显著性(F=47.27,...
医源资料库;在线期刊;齐鲁医学杂志;2009年第24卷第4期IdentificationofFourFimbria-EncodingGenomicIslandsThatAreHighlySpecificforVerocytotoxin-ProducingEscherichiacoliSerotypeO157Strains
...weconductedsuppressionsubtractivehybridization(SSH)betweenthegenomesofthesequencedO157:H7strainEDL933andCL1,aclinicalserotypeO26:H11isolate.GenesfromfourEDL933fimbria-encodinggenomicOislands(OIs)(OI-1,-47,-141,and-154)wereidentifiedintheSSHlibrary.OI-47encodesseveraladditionalputativevirulencefactor...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期ModulatingtheFoldingofP-GlycoproteinandCysticFibrosisTransmembraneConductanceRegulatorTruncationMutantswithPharmacologicalChaperones
...positionseemstobeuniversallyimportantinABCtransportersbecausedeletionoftheequivalentresidue(Tyr490)inP-gpalsoinhibitsmaturationoftheprotein.ThepharmacologicalchaperoneVRT-325canrepairthePhe508-typefoldingdefectsinP-gporCFTR.VRT-325mayrepairthefoldingdefectsbypromotingdimerizationofthetwoNBDsorbyprom...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期七氟醚与异丙酚麻醉BIS为50时血流动力学参数变化
...IS、收缩压(SBP)和平均动脉压(MAP)均显著下降(F=4.14~19.29,q=8.05~12.31,P<0.01),HR在诱导后变化不明显;插管即刻,HR和SBP均上升,且P组、S组上升高于C组,差异有显著性(q=3.09~5.01,P0.05);探查时,P组、S组HR和SBP上升明显高于C组,...
医源资料库;在线期刊;齐鲁医学杂志;2010年第25卷第5期三七根际土壤化感物质的初步分离鉴定
...忌连作植物,轮作间隔期较长,种植过三七的土壤俗称“老七地,其连作障碍表现为“烧须、病多、产量低。三七连作,植株须根减少,影响根部对营养及水分吸收,地上部分生物量减少,根部生长缓慢,根系活力与抗病...
药品天地;专业药学;中药大全;中药材生产技术及质量管理;药用植物栽培管理中西医结合治疗胃食管反流83例
...热疏肝和胃为法,方药如下加减:黄连、栀子、吴茱萸、半夏、香橼、佛手、牡丹皮、青皮、竹茹、枳实、甘草。3)胃阴不足:拟养阴益胃为法,方药如下加减:沙参、枸杞子、当归、生地黄、川楝子、麦冬、玉竹、香橼、佛手...
医源资料库;医学论文;中医中药;中西医结合ControlledClinicalComparisonofPlasticandGlassBottlesofBacT/ALERTFAMediumforCulturingOrganismsfromBloodofAdultPatients
...RTinstrumentfor5daysoruntiltheysignaledpositive.BasedonGramstainresults,aliquotsoftheblood-brothmixtureweresubculturedontoappropriatemediaandincubatedperlaboratoryprotocol.Subsequentidentificationofmicroorganismswasperformedbystandardlaboratorymethods(2).FalsepositivesweredefinedasbottlesthatwereGra...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期头穴针刺对脑出血大鼠脑组织H+-ATPaseβ亚基mRNA表达影响的实验研究
...China【Abstract】ObjectiveTostudytheruleofH+-ATPaseβsubunitmRNA’sexpressindifferentbrainregionafterratintracerebralhemorrhageandscalp-acupunctureregulativeeffect.MethodsTheWistarratsweredividedinto3groups:normalgroup,modelgroup,acupuncturegroup.Everygroupwasdividedintothreetimegroups(...
医源资料库;在线期刊;中华中西医杂志;2007年第8卷第10期Subtype-SpecificAffinityforCorticosteroneofRatOrganicCationTransportersrOCT1andrOCT2DependsonThreeAminoAcidswithintheSubstrateBindingRegi
...50valuesfortheinhibitionofcationuptakebycorticosterone.InmutantrOCT1(L447Y/Q448E),theIC50valuefortheinhibitionof[3H]MPP(0.1e)uptakebycorticosterone(24±4e)wassignificantlyhighercomparedwiththeIC50valueforinhibitionof[14C]TEA(10e)uptake(5.3±1.7e).Thisfindingsuggestsanallostericinteractionbetweentran...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第5期