InhibitionofTcellactivationandautoimmunediabetesusingaBcellsurface–linkedCTLA-4agonist
...munology,UCSF,SanFrancisco,California,USA.AbstractCTL-associatedantigen4(CTLA-4)engagementnegativelyregulatesTcellactivationandfunctionandpromotesimmunetolerance.However,ithasbeendifficulttoexplorethebiologyofselectiveengagementofCTLA-4invivobecauseCTLA-4sharesitsligands,B7-1andB7-2,withCD28.Toaddre...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第8期应用组织多普勒成像技术评价冠心病病人左心室长轴功能的变化
...;心室功能,左;冠状动脉疾病 EVALUATIONOFTHELEFTVENTRICULARLONGAXISFUNCTIONINPATIENTSWITHCORONARYARTERYDISEASEWITHTISSUEDOPPLERIMAGING SONGMINGFANG,LIRONG,WANGZHIBIN,etal (DepartmentofSpecialTreatment,TheSecondSanatorium,Ji′nanMilitaryAreaofThePLA,Qingdao266...
医源资料库;在线期刊;齐鲁医学杂志;2006年第21卷第1期阿魏酸钠对兔急性心肌梗死再灌注后无复流的影响
...钠;炎症;白介素6;P选择素;无复流EffectofsodiumferulateonnoreflowinarabbitmodelofacutemyocardialinfarctionandreperfusionDINGLingyanLIUXianliangZHAOXijunetalDepartmentofCardiovascularMedical,AffiliatedHospitalofBinzhouMedicalUniversity,Binzhou256603【Abstract】ObjectiveT...
医源资料库;在线期刊;滨州医学院学报;2009年第32卷第2期中西医结合治愈扩张型心肌病2例
...:ECG:LBBB+AVBⅠ°。外院心脏彩超左室(LV)86.6mm,左房(LA)43mm,射血分数(EF)14.3%。胸部X线片:肺淤血,心脏扩大,心胸比为0.73,α-HBDH537u/L,LDH302u/L,CK64u/L,CKMB12u/L,三大常规、电解质、肾功均在正常范围,诊断:扩张型...
医源资料库;在线期刊;中华医学实践杂志;2006年第5卷第6期房颤的现代治疗
...患(3)没有发生栓塞的高危因素2.特发性AF(idiopathicatrialfibrillation)难以界定与孤立性AF的区别(1)年龄60岁者不要称孤立性AF(2)左房已扩大或长期AF,心室率快,心脏已重构,超声结构上已有改变,即使无病因可查,也不要用孤立性AF的...
医源资料库;医学文档库;心血管相关羊肠药线穴位植入治疗腰椎间盘突出症
...细胞因子,其中纤维母细胞、软骨细胞产生白细胞介素IL-la、IL-6,能促进细胞浸润引起炎症和组织损伤,尤其是IL-la能增加前列腺素E2(PGE2)的产生,PGE2具有极强的致炎作用,局部达到10-6M浓度就可以直接致痛,即使在更小的浓...
合作平台;在线期刊;中华中西医杂志;2004年第5卷第21期;中西医结合替代疗程对于未接受治疗进展性胃食道癌有效
...受治疗的胃食道癌患者而言,capecitanbine(Xeloda)与oxaliplatin(Eloxatin)显然与fluorouracil(5-FU)与cisplatin(Platinol)在提升整体存活率上一样有效。 试验作者NaureenStarling生物工学学士向Medscape肿瘤学表示,她是一位英国萨...
行业资讯;临床快报;肿瘤相关Dietarypolyunsaturatedfattyacidsandinflammatorymediatorproduction
MichaelJJames,RobertAGibsonandLeslieGCleland1FromtheRheumatologyUnit,RoyalAdelaideHospital,Adelaide,Australia,andtheDepartmentofPediatricsandChildHealth,FlindersMedicalCenter,BedfordPark,Australia.2Reprintsnotavailable.AddresscorrespondencetoMJJames,RheumatologyUnit,RoyalAdelaideHospital,NorthTerrac...
医源资料库;在线期刊;美国临床营养学杂志;2000年71卷第1期Optimizingthecardiovascularoutcomesofweightloss
JennieBrand-Miller1FromtheHumanNutritionUnit,SchoolofMolecularandMicrobialBiosciences,UniversityofSydney,Sydney,Australia2AddressreprintrequeststoJBrand-Miller,SchoolofMolecularandMicrobialBiosciences(G08),UniversityofSydney,Sydney,NSW2006,Australia.E-mail:j.brandmiller{at}mmb.usyd.edu.au.Seecorresp...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第5期PhospholipaseA2-ModifiedLow-DensityLipoproteinActivatesthePhosphatidylinositol3-Kinase-AktPathwayandIncreasesCellSurvivalinMonocyticCells
...oscleroticlesions.WeinvestigatedtheinfluenceofphospholipaseA2-modifiedLDL(PLA-LDL),apro-atherogenicfactor,onactivationofthepro-survivalkinaseAktandcelldeathinmonocyticcells.MethodsandResults-PLA-LDLinducedrobustphosphorylationandactivationofAktinTHP1cells.Italsoattenuatedoxidativestress-inducedcelld...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第11期