Fifty(orMore)WaystoLeaveYourPlatelets(inaThrombus)
...nctionisimpairedinpatientstakingwarfarin.Gas6,likecoagulationfactorsII,VII,IX,andX,isaproteinthatundergoesvitaminK–dependent-carboxylationtoproducetheGlaresiduesnormallyfoundintheGas6N-terminaldomain.Thisprocessingisgreatlyinhibitedorabolishedinpatientstakingwarfarin.ImpairedGlaformationwouldpresu...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第6期InvivoantigendeliverybyaSalmonellatyphimuriumtypeIIIsecretionsystemfortherapeuticcancervaccines
...riumendowedwiththecapacitytodeliverapeptidederivedfromtheinfluenzavirusmatrixprotein(S.typhimurium–Flumatrix),ortheS.typhimuriumcontrolstrain(anidenticalstraincarryingthecontrolplasmidvector).Theabilityoftheinfectedcellstopresentantigentoantigen-specificCD8+Tcellswasthenevaluatedbyenzyme-linkedimm...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第7期CompletePreventionofAtherosclerosisinApoE-DeficientMicebyHepaticHumanApoEGeneTransferWithAdeno-AssociatedVirusSerotypes7and
...irstgenerationAAVvectorsforinvivogenetransfertogenessuchascoagulationfactorIX(F.IX)thatprovidetherapeuticcorrectionofadeficiencyphenotypeatverylowlevelsofexpression.14GenetransfervectorsbasedonnovelAAVserotypes715-17and815-23weremorerecentlyreported.AAV2/7andAAV2/8arechimericvectorsthathavetheinvert...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第8期DecreasedThromboticTendencyinMouseModelsoftheBernard-SoulierSyndrome
【摘要】Objective-Theplateletglycoprotein(GP)Ib-V-IXcomplexisareceptorrequiredfornormalhemostasisdeficientintheBernard-Soulierbleedingdisorder.ToevaluatetheconsequencesofGPIb-V-IXdeficiencyinthrombosiswegeneratedmousemodelsofthediseasebytargetingtheGPIbßsubunit.MethodsandResults-Completede...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第1期代谢综合征与心脑血管事件-人群横断面与前瞻性研究
...TG血症+低HDL血症(1.63%)X:腹型肥胖+低HDL血症+高血糖(1.09%)IX:腹型肥胖+高TG血症+高血糖(1.63%)上海社区人群MS患病特点——ATP(2001)工作定义I:腹型肥胖+高TG血症+高血压+高血糖(34.38%)II:高TG血症+低HDL血症+高血压+高血糖(26.56%)III:...
医源资料库;医学文档库;心血管相关Opticalcoherencetomographycharacterisationofidiopathiccentralserouschorioretinopathy
...nation,lastgenerationOCT(StratusOCT,Softwareversion3.1)andFAwereperformed.SixradialscansusingOCTwereperformedandrepeated.Singularfindingswererecorded,OCTimagesweremeasuredandtheresultscomparedwiththoseofFA.ThemainoutcomemeasureswereFAandOCTfindings.Results:TwopatternsofdistinctOCTfindingsaredescribe...
医源资料库;在线期刊;英国眼科学杂志;2005年第89卷第5期代谢综合征与心脑血管事件-人群横断面与前瞻性研究
...TG血症+低HDL血症(1.63%)X:腹型肥胖+低HDL血症+高血糖(1.09%)IX:腹型肥胖+高TG血症+高血糖(1.63%)上海社区人群MS患病特点——ATP(2001)工作定义I:腹型肥胖+高TG血症+高血压+高血糖(34.38%)II:高TG血症+低HDL血症+高血压+高血糖(26.56%)III:...
医源资料库;医学文档库;心血管相关FHIT基因表达与宫颈鳞癌发病关系*
...HPV16variantanalysisinglandularandsquamousneoplasticlesionsoftheuterinecervix.GynecolOncol,2010,117(2):297-301. 5GiarnieriE,ZanesiN,BottoniA,etal.Oncosuppressorproteinsoffragilesitesarereducedincervicalcancer.CancerLett,2010,289(1):40-45. 6李亚松,石松生,杨卫忠.P73蛋白在...
医源资料库;在线期刊;中华现代临床医学杂志;2011年第9卷第4期MolecularcloningandfunctionalcharacterizationofnovelzinctransporterrZip10(Slc39a10)involvedinzincuptakeacrossratrenalbrush-bordermembrane
...sareference.Westernblotting.Forpreparingthecelllysate,5mlofice-coldPBSTDS(mixed50mlof10xPBSwith5mlof100%TritonX-100,2.5gofsodiumdeoxycholate,0.5gofSDS,and2mlofproteaseinhibitorcocktail)wereaddedtotheLLC-PK1-VecandLLC-PK1-Zip10cellmonolayer.Thecellswereincubatedat4°Cfor10minandthencentrifugedat3,...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期Mutationsintheextracellularloopof-rENaCaltersensitivitytoamilorideandreactivespecies
...rent(y-axis)obtainedateachamilorideconcentrationwascalculatedasfollows:%=[(Ix-I100)/(I0-I100)]x100,whereI0isthecurrentobtainedwithoutamiloride,Ixisthesteady-statecurrentduringperfusionwithagivenconcentationofamiloride(inµM),andI100isthecurrentmeasuredduringperfusionwith100µMamiloride.Val...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第6期