AssociationofBloodPressureIndicesandStrokeMortalityinIsolatedSystolicHypertension
...efollowedameanof13.0±7.3years,and54strokedeathsoccurred.TherelativeimportanceofeachBPindexwascomparedbythedecreaseinthe–2loglikelihood(ameasureofmodelagreementwithdata)becauseoftheadditionof1oracombinationofBPindicestoaCoxregressionmodel.Hazardsratios(HRs)forfatalstrokefora1-SDinBPindexweredeterm...
医源资料库;在线期刊;中风学杂志;2005年第36卷第6期DecreasedExpressionofBmiIsCloselyAssociatedwithCellularSenescenceinSmallBileDuctsinPrimaryBiliaryCirrhosis
【摘要】Cellularsenescenceofbiliaryepithelialcellswithp16INK4aandp21WAF1/Cipexpressionindamagedsmallbileductsmaybecriticalforprogressivebileductlossinprimarybiliarycirrhosis.Weinvestigatedtheinvolvementofbmi1,apolycombgroupgenerepressingp16INK4aexpression,inthepathogenesisofbiliarycellularsenesc...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期Relationbetweenaxiallengthoftheeyeandhypotensiveeffectoflatanoprostinprimaryopenangleglaucoma
UniversityofAlcalá,HospitalOftalmológicoInternacionaldeMadridCorrespondenceto:DrEArranz-MarquezChiquinquira56,Madrid,Spain;esther-arranz@ole.comAcceptedforpublication30April2003ABSTRACTAims:Tostudytheeffectofaxiallengthonthehypotensiveeffectoflatanoprostinprimaryopenangleglaucoma(POAG)inaprospecti...
医源资料库;在线期刊;英国眼科学杂志;2004年第88卷第5期FitnessVersusFatness:theDebateContinues
...setraininginwomenwithawiderange(20.4to39.0)ofbodymassindex(BMI)reducedCRPconcentrationsindependentlyofthemagnitudeofweightloss.Obisesanetal2reportedthatgenevariantsofCRParenotrelatedtoreductionofCRPlevelsinducedbyexercisetraining(24weeks)in63sedentarymenandwomen(prevalenceofobesitynotspecified).Surp...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第3期MitochondrialExpressionoftheDrosophilamelanogasterMultisubstrateDeoxyribonucleosideKinase
...tudiedasacandidatesuicidegeneforapplicationsincombinedgene/chemotherapyofcancer.WehavecreatedanengineeredDm-dNKnucleosidekinasethatistargetedtothemitochondrialmatrix.Theenzymewasexpressedinathymidinekinase1-deficientosteosarcomacellline,andthesensitivityofthecellstocytotoxicnucleosideanalogswasdeter...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期Bevacizumab增加动脉血栓风险
...antinformationforclinicianswhousebevacizumabtotreatpatientswithmetastaticcancer,accordingtotheauthors,ledbycompanyresearcherFrankScappaticci,MD,PhD.ThestudywaspublishedonlineonAugust7intheJournaloftheNationalCancerInstituteandisduetoappearintheAugust15issue.Commentingonthepaper,Genentechspokesperson...
药品天地;专业药学;药品不良反应Effectofdailyorweeklymultiple-micronutrientandironfoodliketabletsonbodyironstoresofIndonesianinfantsaged6–12mo:adouble-blind,rando
...006.4SupportedbyUNICEF(NewYork,NY).5Reprintsnotavailable.AddresscorrespondencetoMWijaya-Erhardt,SEAMEO-TROPMEDRegionalCenterforCommunityNutrition,UniversityofIndonesia,JalanSalembaRaya6,Jakarta10430,Indonesia.E-mail:mwijaya{at}seameo-rccn.org.ABSTRACTBackground:Thereisstilluncertaintyaboutthebestpro...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第6期NF-B2isrequiredfortheestablishmentofcentraltolerancethroughanAire-dependentpathway
...atedtheautoimmunephenotypeofthenativeNfkb2–/–mice,confirmingakeydefectincentraltolerance.Lymphotoxin?receptor(LT?R)ligation–inducedAiregeneexpressionwasalsolargelyabolishedintheabsenceofNF-B2.ThusNF-B2downstreamofLT?RplaysanimportantroleintheregulationofcentraltoleranceinanAire-dependentmanner...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期EffectivenessofMedicalResidentEducationinMechanicalVentilation
...Illinois: ABSTRACTTOPABSTRACTINTRODUCTIONMETHODSRESULTSDISCUSSIONREFERENCESSpecificmethodsofmechanicalventilationmanagementreducemortalityandlowerhealthcarecosts.However,inthefaceofapredicteddeficitofintensivists,itisunclearwhetherresidencyprogramsaretraininginterniststoprovideeffectivecareforpa...
医源资料库;在线期刊;美国呼吸和危急护理医学;2003年第167卷第1期LessthantheSumofItsParts:FailureofaTenofovir-Abacavir-LamivudineTriple-NucleosideRegimen
...ent.Intheirstudy,Gallantetal.randomized340treatment-naivesubjectstoreceiveonce-dailytenofovirDF/abacavir/lamivudineorefavirenz/abacavir/lamivudine.Baselinecharacteristics(medianplasmaHIV-1RNAlevelof4.7log10copies/mLandmedianCD4+cellcountof251cells/mm3)weresimilartothoseofsubjectsfrommostcontemporary...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第23期