ANovelProstaglandinEReceptor4eCAssociatedProteinParticipatesinAntiinflammatorySignaling
...ivationinmacrophagesremainsundefined,wesoughtinteractorswiththecarboxyl-terminalcytoplasmicdomainoftheEP4receptor.Yeast2-hybridscreeningofthehumanbonemarrowcDNAlibrarywiththeEP4receptorasabaitidentifiedacDNAcloneencodinga669-aminoacidprotein,designatedhereasEP4receptor-associatedprotein(EPRAP),which...
医源资料库;在线期刊;循环研究杂志;2006年第96卷第3期Plasmalycopene,othercarotenoids,andretinolandtheriskofcardiovasculardiseaseinwomen
HowardDSesso,JulieEBuring,EdwardPNorkusandJMichaelGaziano1FromtheDivisionofPreventiveMedicine,DepartmentofMedicine,BrighamandWomen‘sHospitalandHarvardMedicalSchool,Boston(HDS,JEB,andJMG);theDepartmentofEpidemiology,HarvardSchoolofPublicHealth,Boston(HDSandJEB);theMassachusettsVeteransEpidemiologyR...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第1期LithiumReducesTauPhosphorylationbutNotAßorWorkingMemoryDeficitsinaTransgenicModelwithBothPlaquesandTangles
...tbipolardisorder.Here,weinvestigatethetherapeuticefficacyofchroniclithiumadministrationinaged3xTg-ADmicethatharborbothplaquesandtangles.WefoundthatlithiumreducedtauphosphorylationbutdidnotsignificantlyaltertheAßload.Despitethereductioninphosphotau,lithiumtreatmentdidnotimprovedeficitsinworking...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期ErythrophagocytosisbyLiverMacrophages(KupfferCells)PromotesOxidativeStressInflammationandFibrosisinaRabbitModelofSteatohepatitis
...swithfibrosisandhighmRNAexpressionforsomecytokines,hemeoxygenase-1,transforminggrowthfactor-ß1,andcollagen1(I).Erythrocytesisolatedfromthemodelshowedmarkedfragilityandtheexternalizationofphosphatidylserine(PS)ontheouterleafletofthemembraneandwerefrequentlyengulfedbyKupffercells/macrophagesinth...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第3期AgeModeratestheShort-TermEffectsofTransdermal17ß-EstradiolonEndothelium-DependentVascularFunctioninPostmenopausalWomen
...adouble-blindcrossoverdesign,100postmenopausalwomenaged50to80yearswererandomizedtoeachof3transdermalpatches,releasing17ß-estradiol(0.05mg/d),17ß-estradiol(0.05mg/d)+norethindroneacetate(NETA,0.14mg/d),andplacebo.Flow-mediateddilation(FMD)andresponseto400µgsublingualglyceryltrinitra...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第8期n-3Polyunsaturatedfattyacids,fatalischemicheartdisease,andnonfatalmyocardialinfarctioninolderadults:theCardiovascularHealthStudy
...rdiovascularHealthResearchUnit,DepartmentsofMedicine(RNL,DM,andDSS)andEpidemiology(DSS),UniversityofWashington,Seattle;thePublicHealthSciencesDivision,FredHutchinsonCancerResearchCenter,Seattle(IBK);theHealthServicesProgram,PugetSoundVeteransAffairsMedicalCenter,Seattle(DM);theDepartmentofEpidemiolo...
医源资料库;在线期刊;美国临床营养学杂志;2003年77卷第2期AssociationBetweenaFunctionalVariantoftheKLOTHOGeneandHigh-DensityLipoproteinCholesterol,BloodPressure,Stroke,andLongevity
...ociatedwithhumanagingandearly-onsetoccultcoronaryarterydisease.Here,wedeterminewhethertheKL-VSalleleinfluencescardiovasculardiseaseriskfactors,cardiovascularevents,andultimately,mortality.Atotalof525AshkenaziJewscomposedof216probands(age95years)and309unrelatedindividuals(ages51to94)weregenotypedfort...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第3期PhosphataseandTensinHomologDeletedonChromosome10(PTEN)ReducesVascularEndothelialGrowthFactorExpressioninAllergen-InducedAirwayInflammation
...fectsofPTENonVEGF-mediatedsignalinginasthmaareunknown.ThisstudyaimedtodeterminetheeffectofPI3KinhibitorsandPTENonVEGFexpressioninallergen-inducedairwayinflammation.WehaveusedafemaleC57BL/6mousemodelforasthmatodeterminetheroleofPTENinallergen-inducedairwayinflammation,specificallyintheexpressionofVEG...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期ARandomizedTrialofMontelukastinRespiratorySyncytialVirusPostbronchiolitis
...nfantswhowere3to36monthsold,hospitalizedwithacuteRSVbronchiolitis,wererandomizedintoadouble-blind,parallelcomparisonof5-mgmontelukastchewabletabletsormatchingplacebogivenfor28daysstartingwithin7daysofsymptomdebut.Infantswithasuspectedhistoryofasthmawereexcluded.Onehundredsixteeninfantsprovideddiaryc...
医源资料库;在线期刊;美国呼吸和危急护理医学;2003年第167卷第3期Oralargininedoesnotstimulateanincreaseininsulinconcentrationbutdelaysglucosedisposal
...olicResearchLaboratoryandtheSectionofEndocrinology,Metabolism,andNutrition,MinneapolisVeteransAdministrationMedicalCenter(MCG,JAN,andFQN),andtheDepartmentsofFoodScienceandNutrition(MCG)andMedicine(MCGandFQN),UniversityofMinnesota,Minneapolis.2SupportedinpartbyagrantfromtheMinnesotaMedicalFoundation,...
医源资料库;在线期刊;美国临床营养学杂志;2002年76卷第5期