应变率和组织速度成像技术对急性心肌缺血右心功能评价的对比研究

...右房壁及三尖瓣环的收缩期峰值应变率和运动速度（SSR、VS）、舒张早期峰值应变率和运动速度（ESR、VE）、舒张晚期峰值应变率和运动速度（ASR、VA）、右室射血分数（RVEF）和用导管法测肺动脉收缩压（PASP）。结果左室局部急...

CD40/CD154ligationinducesmononuclearcelladhesiontohumanrenalproximaltubulecellsviaincreasedICAM-1expression

...h)-,2.5±0.4(15h)-,and3.2±0.3(24h)-fold(n=4,P<0.05forthe2-and4-htimepointsvs.0h).IfICAM-1expressionlevelsarenotcorrectedfor-actinexpressionlevelsinthisexperiment,actualmRNAvaluescanbeobtained.By2h,ICAM-1mRNAhadincreasedabouteightfoldfromanunstimulatedvalueof3.9±1.2(107pmol)to31.8±0.8(107pmol;n=3,...

Sensitizationofpelvicnerveafferentsandmastcellinfiltrationintheurinarybladderfollowingchroniccolonicirritationismediatedbyneuropeptides

...ssignificantlyaccentuatedfollowingTNBScomparedwithcontrols(1,222±176vs.624±54%,P0.01).TheresponsetovCPwasalsoenhanced(4,126±775vs.1,979±438%,P0.01).Systemicdepletionofneuropeptidesfromsensorynervesabolishedtheseeffects.Histologicalexaminationofthebladdersrevealedanincreas...

Endothelin-Aand-Breceptors,superoxide,andCa2+signalinginafferentarterioles

...eheterodimerizationITHASBECOMEWELLESTABLISHEDthatvascularsmoothmusclecells(VSMC)ofpreglomerularvesselscontainbothendothelin-Aand-Breceptors(ETARandETBR).WehavepreviouslydemonstratedthatstimulationofpreglomerularVSMCandafferentarteriolesegmentswiththeETBRselectiveagonistIRL-1620orwithendothelin-1(ET-...

辛伐他汀对高胆固醇血症患者RANTES表达的影响

...脂组的血浆AngⅡ水平较对照组明显升高[（92．13±22．03）vs（50．85±12．12），P〈0．01]，他汀组明显降低[（78．57±18．35）vs（92．13±22．27），P〈0．05]。②高脂组单个核细胞RANTES的mRNA和蛋白质表达较对照组明显升高[（0．87±0．19...

AT1receptor-mediatedenhancementofcollectingductrenininangiotensinII-dependenthypertensiverats

...esartan(5mg/days,n=8).ANGIIinfusionincreasedsystolicbloodpressure(BP;178±4vs.122±1mmHg;P<0.001)andsuppressedplasmareninactivity(PRA;0.08±0.1vs.5.3±0.8ngANGI・ml1・h1).ARBtreatmentpreventedtheincreaseinBP(113±6mmHg)andledtoincreasesinPRA(15.8±1.5ngANGI・ml1・h1).Reninproteinlevelsmeasuredin...

ProstaglandinE2promotescellsurvivalofglomerularepithelialcellsviatheEP4receptor

...tifiedfromrandomlychosenfields.Atleast400cellswerecounted/condition.*P<0.01vs.EtOH,n=3.InductionofCOX-2stimulatestheERKpathway.TheERKpathwayisknowntomediatecellproliferationandsurvival(8).Tobegintoaddressthemechanismsofproliferativeandanti-apoptoticeffectofCOX-2induction,wenextstudiedwhetherCOX-2ind...

Molecularanalysisofimpairedurinarydilutingcapacityinglucocorticoiddeficiency

...byoralgavage),GDratsdemonstratedadecreaseinpercentwaterexcretion(5±1vs.33±9%,P0.01)andurinaryoutput(33±12vs.250±65µl·kg-1·min-1,P0.05)andanincreaseinUosm(1,894±292vs.316±92mosmol/kgH2O,P0.001)comparedwithCTLrats.PlasmaAVPwasincreased(1.6&...

重症慢性阻塞性肺疾病患者预后因素分析

...频率（respiratoryrate,RR）明显低于生存组［（68.2±21.2）mmHgvs（82.8±23.7）mmHg;（7.1±5.1）vs（9.8±5）；（21.8±7.8）次/minvs（30.1±8.4）次/min］,而血肌酐、APACHEⅢ评分高于生存组［（180±60）μmol/Lvs（110±50）μmol/L;（92.4±28.3）vs（77.6±27.2...

房室间隔缺损患儿血浆心钠素与心脏指数及钠排泄关系的探讨

...心脏病患儿血浆ANP水平明显高于正常对照组（217.23±83.04vs17.51±6.55，P0.05），CI则明显低于正常对照组（3.32±0.35vs4.06±0.33，P0.05）。FENa%与正常对照组比较无明显差异（0.37±0.06vs0.38±0.07，P0.05）。54例患儿血浆ANP水平与CI呈负相关（...