肺淋巴管平滑肌瘤病1例并文献复习
...分析:pH7.45,PCO228mmHg,PO264mmHg,SaO293%。胸水生化:TP86.2g/L,GLU6.08mmol/L,LDH78.8U/L,CHO2.31mmol/L,TG26.71mmol/L。血生化:CHO4.92mmol/L,TG1.24mmol/L。血抗SM、抗SSA、抗SSB、抗rRNP、dsDNA等均阴性。双肺HRCT:双肺弥漫性囊变,左侧胸腔积液。纤支...
医源资料库;在线期刊;滨州医学院学报;2009年第32卷第3期MolecularInteractionsofCCR5withMajorClassesofSmall-MoleculeAnti-HIVCCR5Antagonists
...sliningthepocket.ExceptforTAK-779,allantagonistsshowedstronginteractionwithGlu283inTM7viatheircentralbasicnitrogen.ThefullymappedbindingpocketofCCR5isbeingusedforstructure-baseddesignandleadoptimizationofnovelanti-HIVCCR5inhibitorswithimprovedpotencyandbetterresistanceprofile.Humanimmunodeficiencyvi...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期加味甘麦大枣汤对嗅球摘除所致抑郁症模型大鼠行为学及氨基酸递质含量的影响
...、疏肝组γ-GABA/GLu比值下降。结论甘麦大枣汤及其加味方能够纠正嗅球摘除所致抑郁症模型大鼠行为学变化,但不同加味药对氨基酸类递质含量的影响存在不同。关键词甘麦大枣汤抑郁症行为学氨基酸类神经递质EffectsofGanmaiDazaoDe...
合作平台;在线期刊;中华现代中西医杂志;2004年第2卷第11期;论著DeterminationofBindingSiteResiduesResponsiblefortheSubunitSelectivityofNovelMarine-DerivedCompoundsonKainateReceptors
...cidatewhyDH,anagonist,andMSVIII-19,acompetitiveantagonist,bindselectivelytoglutamatereceptor(GluR)5butnottotheKA2KARsubunit,weusedmoleculardynamicssimulationstogeneratebindingmodelsthatweretestedexperimentallyinradioligandbindingandelectrophysiologicalassays.Threecandidatesites,Val685,Leu735,andSer7...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期AtomicForceMicroscopyRevealstheStoichiometryandSubunitArrangementofthe4β3GABAAReceptor
...oreaFLAG-His6tag;theβ3-subunitboreaV5-His6tag,andthe-subunitboreahemagglutinin-(HA-)His6tag.AlltagswereattheC-terminiofthesubunits.IncellstransfectedwithcDNAsforallthreesubunits(ata1:1:1ratiobyweight),anti-His6,anti-FLAG,anti-V5,andanti-HAantibodiesallgavepositiveimmunofluorescencesignals,butan...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期ImprovedLaboratorySafetybyDecontaminationofUnstainedSputumSmearsforAcid-FastMicroscopy
...torystaff.Wecomparedtheeffectivenessof1%and5%sodiumhypochlorite,5%phenol,2%glutaraldehyde,and3.7%formalininkillingMycobacteriumtuberculosispresentinsmearspreparedfrom51sputumsamples.Thesmearsweredecontaminatedbythetubeandslidetechniques.Phenolat5%,glutaraldehydeat2%,andbufferedformalinat3.7%for1min(...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期RoleofADAMTS-1inAtherosclerosis
...ms,respectively.7ADAMTS-1andADAMTS-4havebeenshowntocleaveV1/V0versicanattheGlu441-Ala442/Glu1428-Ala1429bondandtheproductofthiscleavagewasshowntobepresentinhumanatheroscleroticplaquesbyimmunohistochemistryusingneo-epitopeantibodies.8ADAMTS-1hasalsobeenshowntohavearoleinmatrixremodelingduringovulatio...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期EmergenceofaStreptococcuspneumoniaeClinicalIsolateHighlyResistanttoTelithromycinandFluoroquinolones
...followingfourquinoloneresistance-determiningregionsanalyzed:Ser-81Phe,gyrA;Glu-474Lys,gyrB;Ser-79PheandLys-137Asn,parC;andIle-460Val,parE(Table1).ThesamemutationsweredescribedbyNagaietal.inanS.pneumoniaemutantstrainusinggatifloxacinasselector(16),butthisisthefirsttimethatsuchaminoacidchangeshavebeen...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第11期中药新药长毒动物血液生化测定SOP建立研究
...、白蛋白(ALB)、尿素(Urea)、肌酐(Cre)、葡萄糖(Glu)、总胆固醇(CHO)、总胆红素(TBil)等生化值进行测定,以探讨血液不同制备方法对其血液生化值的影响。结果表明,血液样品制备过程中,抗凝与否,离心条件(温...
药品天地;专业药学;中药大全;中药研究与新药申报RapiGestSF试剂:促进溶液中蛋白酶解的有利工具
...是帮助酶消解的有利工具,可促进溶液中蛋白的消解,它能够改善样品制备过程中蛋白的溶解度。 RapiGestSF提高酶解速率与完全程度的机理详见图1。温和的蛋白变性可打开蛋白结构并暴露酶切位点,以供酶切。在RapiGestSF溶液...
药品天地;专业药学;实验技术;色谱技术;色谱分析实例