Morethancolocalizingwithpolycystin-1,polycystin-Lisinthecentrosome
...somaljunctionthanwithE-cadherin.AsubpopulationofPCLwasalsopresentintheER,asdemonstratedbythecostainingwithconcanavalinA(Fig.2B,j-l).Fig.2.CommondistributionofPCLandPC1inconfluentinnermedullarycollectingduct(IMCD)cells.LocalizationofPC1andPCLwasdeterminedbyimmunofluorescencemicroscopyinpolarizedIMCDc...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期ModulationofpMitogen-ActivatedProteinKinaseCascadeandMetalloproteinaseActivityinDiaphragmMuscleinResponsetoFreeRadicalScavengerAdministrati
...erofadaptorproteinsinvolvedinavarietyofsignalingcascades.13,14Ithasalsobeendemonstratedthattheinteractionofdystroglycanwithlamininhasaninhibitoryeffectontheactivationoftheextracellularsignal-regulatedkinase(ERK)-mitogen-activatedprotein(MAP)kinasecascadeinresponsetothebindingofintegrinstolaminin.8Th...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第2期Subunit-StoichiometricEvidenceforKir6.2ChannelGating,ATPBinding,andBinding-GatingCoupling
...rstandsubunitstoichiometryfortheATP-dependentchannelgating,weconstructedtandem-multimericKir6.2channelsbyselectivedisruptionofthebindingorgatingmechanismincertainsubunits.StepwisedisruptionsofchannelgatingcausedgradedlossesinATPsensitivityandincreasesinbasalPopen,withnoeffectonmaximumATPinhibition.P...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期Identificationofhumanurinarytrefoilfactor1asanovelcalciumoxalatecrystalgrowthinhibitor
...time-of-flightMSandelectrosprayionization–quadrupole–time-of-flighttandemMSashumantrefoilfactor1(TFF1).Westernblotanalysisconfirmedthemassspectrometricproteinidentification.FunctionalstudiesofurinaryTFF1demonstratedthatitsinhibitorypotencywassimilartothatofnephrocalcin.Theinhibitoryactivityofuri...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第12期Megalinmediatesrenaluptakeofheavymetalmetallothioneincomplexes
...lableintheproximaltubuleforcompetitionwithMTtoactasprotectiveagents,ifwecandemonstratethatinhibitionobservedindirectmolecularinteractionsmatchesthewholeanimalpathophysiology.Ourresults,reportedhere,indicatethatmegalinbindsMTandimplicatesthehighlyconservedhingeorinterdomainregionofMT,centeredonalysin...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第9期Apoa5Q139Xtruncationpredisposestolate-onsethyperchylomicronemiaduetolipoproteinlipaseimpairment
...neInterne,HopitalRobertDebré,ReimsCedex,France.AbstractWhiletype1hyperlipidemiaisassociatedwithlipoproteinlipaseorapoCIIdeficiencies,theetiologyoftype5hyperlipidemiaremainslargelyunknown.Weexploredanewcandidategene,APOA5,forpossiblecausativemutationsinapedigreeoflate-onset,verticallytransmittedhype...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期High-ThroughputScreeningforSmall-MoleculeActivatorsofNeutrophils:IdentificationofNovelN-FormylPeptideReceptorAgonists
...unstimulated,restingcellswascompletelyinhibitedby10U/mLsuperoxidedismutase,demonstratingspecificityofthisassaysystem(datanotshown).2-foldenhancementofROSproductioncomparedwithbaselineROSproductionatafinalcompoundconcentrationof20µg/ml.Primaryscreeningresultedintheselectionof523compoundsfromthe...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第4期AcetaminophenRecruitsSpinalp42/p44MAPKsandGH/IGF-1ReceptorstoProduceAnalgesiaviatheSerotonergicSystem
...dicale(INSERM)U766,PharmacologieFondamentaleetCliniquedelaDouleur,FacultésdeMédecineetdePharmacieandUniversitéClermont1,FacultédeMédecine,LaboratoiredePharmacologieMédicale,Clermont-Ferrand,France(J.B.,L.D.,M.E.,E.Ch.,作者:
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第2期ImmunomodulationofAtherosclerosis
...pressivedrugsalsohaveadverseaffectsoncardiovascularriskfactorssuchasdyslipidemia,hypertension,anddiabetes.TheimmunosuppressivecompoundscyclosporinAandrapamycinnotonlyactonTcellsbutcanalsoinhibitsmoothmuscleproliferationandtheresponsetovascularinjury.9,10Coatingofstentswithrapamycinmaythereforehelppr...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期InsulinpotentiatesAVP-inducedAQP2expressioninculturedrenalcollectingductprincipalcells
...tockholm,SwedenInstitutNationaldelaSantéetdelaRechercheMédicaleU,FacultédeMédecineXavierBichat,Paris,FranceABSTRACTIntherenalcollectingduct(CD),waterreabsorptiondependsonthepresenceofaquaporin-2(AQP2)intheapicalmembraneofprincipalcells.AQP2expressionandsubcellularrepartitionareunderthecontrolofA...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第2期