Apoa5Q139Xtruncationpredisposestolate-onsethyperchylomicronemiaduetolipoproteinlipaseimpairment
...neInterne,HopitalRobertDebré,ReimsCedex,France.AbstractWhiletype1hyperlipidemiaisassociatedwithlipoproteinlipaseorapoCIIdeficiencies,theetiologyoftype5hyperlipidemiaremainslargelyunknown.Weexploredanewcandidategene,APOA5,forpossiblecausativemutationsinapedigreeoflate-onset,verticallytransmittedhype...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期High-ThroughputScreeningforSmall-MoleculeActivatorsofNeutrophils:IdentificationofNovelN-FormylPeptideReceptorAgonists
...unstimulated,restingcellswascompletelyinhibitedby10U/mLsuperoxidedismutase,demonstratingspecificityofthisassaysystem(datanotshown).2-foldenhancementofROSproductioncomparedwithbaselineROSproductionatafinalcompoundconcentrationof20µg/ml.Primaryscreeningresultedintheselectionof523compoundsfromthe...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第4期AcetaminophenRecruitsSpinalp42/p44MAPKsandGH/IGF-1ReceptorstoProduceAnalgesiaviatheSerotonergicSystem
...dicale(INSERM)U766,PharmacologieFondamentaleetCliniquedelaDouleur,FacultésdeMédecineetdePharmacieandUniversitéClermont1,FacultédeMédecine,LaboratoiredePharmacologieMédicale,Clermont-Ferrand,France(J.B.,L.D.,M.E.,E.Ch.,作者:
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第2期ImmunomodulationofAtherosclerosis
...pressivedrugsalsohaveadverseaffectsoncardiovascularriskfactorssuchasdyslipidemia,hypertension,anddiabetes.TheimmunosuppressivecompoundscyclosporinAandrapamycinnotonlyactonTcellsbutcanalsoinhibitsmoothmuscleproliferationandtheresponsetovascularinjury.9,10Coatingofstentswithrapamycinmaythereforehelppr...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期InsulinpotentiatesAVP-inducedAQP2expressioninculturedrenalcollectingductprincipalcells
...tockholm,SwedenInstitutNationaldelaSantéetdelaRechercheMédicaleU,FacultédeMédecineXavierBichat,Paris,FranceABSTRACTIntherenalcollectingduct(CD),waterreabsorptiondependsonthepresenceofaquaporin-2(AQP2)intheapicalmembraneofprincipalcells.AQP2expressionandsubcellularrepartitionareunderthecontrolofA...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第2期ProcoagulantMicroparticles
...rcircumstancesofdrasticendothelialactivation.10,22,23Leukocyte-derivedMPsandEMPswerealsodemonstratedtoinduceTFexpressionbymonocytesendothelialcells.10,24,25ThedebateremainsastowhetherTFexposedattheMPsurfaceisamajorfactorforMPthrombogenicity,26,27TFencryption/de-encryptionbeingaprobablecrucialstep.Ac...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第12期Eosinophiladhesionunderflowconditionsactivatesmechanosensitivesignalingpathwaysinhumanendothelialcells
...astherateofneutrophiltransmigrationisincreasedbyshearstress(3).WepreviouslydemonstratedthatafeweosinophilscouldtransmigrateacrossIL-4–stimulatedendothelialcellsunderstaticconditions;however,shearstressmustbepresentformaximumtransmigrationtooccur(4).Althoughthesestudieshaveestablishedthatshearstres...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第6期Sex-differentialexpressionofornithineaminotransferaseinthemousekidney
...riectomized.Indeed,regulationofOatbyestrogens(including17--estrogen)hasbeendemonstratedinfemaleratkidneys(26,29,30).Unfortunately,ourresultssupportthatfemalesexhormonesdonotregulatetheexpressionofOatinfemalemousekidneys.ThesexualdimorphismofOatexpressioninthemousekidneyledustoexplorewhetherOatexhibi...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第3期A46-AminoAcidSegmentinPhosphodiesterase-5GAF-BDomainProvidesforHighVardenafilPotencyoverSildenafilandTadalafilandIsInvolvedinPhosphodiest
...nafilandUK-122764),tadalafil,andthreevardenafil-basedinhibitors(vardenafil,demethyl-vardenafil,andBAY51-1871](Fig.1).Themutantswerealsoanalyzedfortheirquaternarystructures.WereportherethatGAF-BinPDE5RdomainplayedakeyroleindetermininghigheraffinityandselectivityofPDE5forvardenafil-basedcompoundsversu...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期NeurotrophinspromoterevascularizationbylocalrecruitmentofTrkB+endothelialcellsandsystemicmobilizationofhematopoieticprogenitors
...esselsforonlyalimitedduration(1-3).DirectintroductionofVEGF-A,FGF-1,orFGF-2demonstratedsomebenefitinrestoringvascularizationofischemicmyocardiumorlimbs,buttheseeffectswerefoundtodiminishovertime.Theseobservationshaveraisedthepossibilitythatlong-lastingvesselstabilitymaybemediatedthroughtherecruitmen...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期