OrphaninFQ/NociceptinPotentiates[D-Ala2,N-Me-Phe4,Gly5-ol]-EnkephalineCInducedeOpioidReceptorPhosphorylation
...ciceptinopioidpeptide(NOP)receptor,desensitizesthee?opioidreceptor.WedescribedpreviouslytheinvolvementofproteinkinaseCandG-protein-coupledreceptorkinases(GRK)2and3inOFQ/N-inducede?receptordesensitization.Becausephosphorylationofthee?receptortriggersthesuccessiveregulatorymechanismsresponsiblefordese...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第2期IL-2productionindevelopingTh1cellsisregulatedbyheterodimerizationofRelAandT-betandrequiresT-betserineresidue508
...sthatareresponsibleforitsdown-regulationinlaterstagesofThdevelopmenthavenotbeenstudiedasmuch.PreviousworkfromourlaboratoryrevealedarepressorfunctionfortheT-boxtranscriptionfactor,T-bet,inIL-2genetranscription.Here,wereportthatT-betS508isrequiredfortheoptimalrepressionofIL-2productionindevelopingTh1c...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第9期重症肌无力危象1例的护理
...使用呼吸机前血气结果示:PO2188.7mmHg,PCO2191.3mmHg,pH6.997,BE8.8mmol/L,BEecf14.5mmol/L,HCO-345.8mmol/L,BB55.8mmol/L,SO2(c)98.8%。使用后血气示:PO271.5mmHg,PCO291.5mmHg,pH7.249,BE8.6mmol/L,BEecf11.8mmol/L,HCO-339.1mmol/L,BB55.5mmol/L,SO2(c)91.4%。病情逐渐好转...
医源资料库;在线期刊;中华现代内科学杂志;2006年第3卷第11期主支气管断裂的外科治疗
....Itwassterilebyremovingthegasfromtheleftthorax.Wethoughtthathisbronchicouldbebroken.TheoperationofbronchianastomosiswasperformedundergeneralanesthesiainFebruary1st2005.Itwasstrengthenbyusingantibioticandmanagingaspiratorytractafteroperation.ResultsTheleftlungwasexpandedbest,andtheanesthesiawasexpe...
资料库;在线期刊;中华现代外科学杂志;2005年第2卷第7期抢救治疗急性乙二醇中毒3例临床体会
...。实验室检查:电解质及肾功能化验未见异常,血pH7.3,BE5.9mmol/L,WBC11.8×109/L,N80%。入院后即催吐、导泄,吐出大量胃内容物。住院次日给病人脑细胞活化剂(ATP,CoA等)、VitC、B族维生素,以保护脑细胞;给甘露醇、地塞米松等...
合作平台;医学论文;预防医学与公共卫生学论文;职业病与地方病以肺出血合并多器官损伤为首发表现的重症手足口病1例
...生理盐水扩容。随即查血气:pH7.09,PO266mmHg,PCO251mmHg,BE-18mmol/L,Na+129mmol/L,BE14.3mmol/L,Glu27mmol/L,予NaHCO3纠酸、3%NaCl纠正低钠血症及胰岛素降血糖。30min后:稍烦躁,机械通气下未见泡沫痰涌出,SaO2维持在95%左右,肺部啰音较前...
医源资料库;在线期刊;中华现代儿科学杂志;2010年第7卷第3期支气管哮喘
...农村仍可见到。3.食物 由于饮食关系而引起哮喘发作的现象在哮喘病人中常可见到,尤其是婴幼儿容易对食物过敏,但随年龄的增长而逐渐减少。引起过敏最常见的食物是鱼类、虾蟹、蛋类、牛奶等。4.气候改变 当气温、温...
求医问药;疾病手册;呼吸内科Randomizedphase2trialofanti-tumornecrosisfactortherapyforcachexiainpatientswithearlyrheumatoidarthritis
...ormalizetheanabolicresponsetooverfeedingand,ifthesefindingsareconfirmed,maybeusefulinconditionscharacterizedbyanorexiaandweightloss.KeyWords:CachexiatumornecrosisfactorrheumatoidarthritisbodycompositionweightgainINTRODUCTIONCachexia,definedasanacceleratedlossofskeletalmusclei...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第6期AReviewoftheEvidenceforProblemSolving
...ctiveproblem-solvingskillstofamilycaregiversofpatientswithchronicdiseasehasbeenshowntobeusefulforpromotingphysicalandpsychosocialwell-being.However,theuseandeffectivenessofproblemsolvingforsupportingcaregiversinstrokecarehasnotbeenreviewed.Thisarticleaimstoidentifyandreviewstudiesthathaveexaminedthe...
医源资料库;在线期刊;中风学杂志;2005年第36卷第11期Bmi-IsEssentialfortheTumorigenicityofNeuroblastomaCells
...reaseinthelevelsofBmi-1expression.Bmi-1cooperatedwithMYCNintransformationofbenignS-typeneuroblastomacellsandavianneuralcrestcellsbyinhibitingtheapoptoticactivityofMYCN.Importantly,down-regulationofBmi-1impairedtheabilityofneuroblastomacellstogrowinsoftagarandinducetumorsinimmunodeficientmice.Moreove...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第4期