CyclosporinATrapsABCA1atthePlasmaMembraneandInhibitsABCA1-MediatedLipidEffluxtoApolipoproteinA-I
...P-gp),whichisitselfanABCtransporter(ABCB1).12SeveralstudieshaveimplicatedP-gpincellularcholesterolmetabolismandtrafficking.13–15Inratastrocytes,ItoetalhavereportedthatapoAIinducestranslocationofcholesterolandphospholipidstothecytosolandthatthesereactionsaresuppressedbyCsA.16Thus,weinitiatedaseries...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第11期DistinctRolesofEphrin-B2ForwardandEphB4ReverseSignalinginEndothelialCells
...phrin-Asubclass(ephrin-A1to-A5)aretetheredviaaglycosylphosphatidylinositol(GPI)anchor,whereasthe3membersoftheephrin-Bsubclass(ephrin-B1to-B3)haveatransmembranedomainandhighlyconservedcytoplasmicdomains.Ephrin-BligandsinteractprimarilywiththeBsubsetofEphreceptors,whichconsistofatleast6members.6,7Acha...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2003年第23卷第2期Prostasinattenuatesinduciblenitricoxidesynthaseexpressioninlipopolysaccharide-inducedurinarybladderinflammation
...ttentionbecauseoftheirmembrane-anchorageviatheglycosylphosphatidylinositol(GPI)group.Theseproteasesareshownorbelievedtobeactiveextracellularenzymes,examplesareprostasin,TESP5/testisin/esp-1,and-tryptases(3,7,23).Thesemembrane-anchoredserineproteasesmaypotentiallyactinverydifferentwaysthantheclassics...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第9期Roleofdifferentpathwaysofthecomplementcascadeinexperimentalbullouspemphigoid
...ritis,thejointdiseaseistriggeredbyanti–glucose-6-phosphateisomerase(anti-GPI)antibodiesand,likeexperimentalBP,dependsonPMNsandMCs(42–44).UnlikeexperimentalBP,thisarthritismousemodelrequiresthealternativepathway,andtheclassicalpathwayisentirelydispensable(45).Thedifferenceinthecomplementpathwayus...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期Globalanalysisofproliferationandcellcyclegeneexpressionintheregulationofhematopoieticstemandprogenitorcellfates
...5%Tween20.Cellswerefinallyresuspendedin500μlPBScontaining10μgRNaseAand5μgPI,incubatedfor30min,andimmediatelyanalyzedonaFACScan(BectonDickinson).H/PYstainingDoubleFACS–sortedstem,progenitor,andmaturecellpopulationswereincubatedfor45minat37°Cwith20μg/mlHOECHST33342(Invitrogen)inHBSSmediumcontai...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第11期“Viraldéjàvu“elicitsorgan-specificimmunediseaseindependentofreactivitytoself
...AbsenceofinflammatoryCNSdiseaseinrLCMV/INDGcarrierschallengedwithrVSV/LCMV-GPinsteadofARM.rLCMV/INDGcarriers(50daysold)werechallengedeitherwithARMorwithrVSV/LCMV-GPi.v.(AandB)Bodyweight(A)andrunningtimeontherotatingrod(B)weremonitoredattheindicatedtimepointsafterARMchallenge.Shownarethemean±SEMof5m...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期DifferentialSensitivitiesoftheHumanATP-BindingCassetteTransportersABCG2andP-GlycoproteintoCyclosporinA
...nandPastan,1993).Inadditiontoconferringresistancetotheseanticanceragents,P-gpisknowntotransportothercompoundssuchashumanimmunodeficiencyvirusproteaseinhibitors(Kimetal.,1998;Leeetal.,1998).Therefore,theexpressionofP-gpcan,inprinciple,compromisetreatmentofavarietyofdisorders.P-gpisa170-kDa,glycosylat...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第3期ProcoagulantMicroparticles
...erproviders.1,2MPsharborfunctionalmembraneorcytoplasmiceffectors(selectins,GPIIbIIIa,GPIb,vonWillebrandfactor,arachidonicacid,thromboxaneA2,etc.)abletopromoteprothromboticresponses.Whenbearingappropriatecounterligands,MPscantransfertheirprocoagulantpotentialtotargetcells.Forinstance,platelet-derived...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第12期TransgenicExpressionoftheActivatingNaturalKillerReceptorLy49HConfersResistancetoCytomegalovirusinGeneticallySusceptibleMice
...ecognitionoftheMCMV-encodedmoleculem157(21,22),aglycoinositolphospholipids(GPI)-linkedproteinstructurallyrelatedtononclassicalMHC.WhileseverallinesofexperimentsclearlydemonstratethatabsenceofLy49HisassociatedwithMCMVsusceptibility,itwasimportanttoevaluatetheroleofthedistal200-kbregionduringtheMCMVre...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第3期TheBreastCancerResistanceProtein(Bcrp1/Abcg2)LimitsFetalDistributionofGlyburideinthePregnantMouse:AnObstetric-FetalPharmacologyResearchUnit
...ved.Furthermore,suchatransferofGLBwasnotblockedbytheadditionofverapamil,aP-gpinhibitor(Kraemeretal.,2006).Basedonthesedata,theauthorsconcludedthatGLBiseffluxedbyatransporterotherthanP-gporthatP-gpisnotamajorplayer.WehavepreviouslyshownthatverapamilisnotaneffectiveinhibitorforBCRP(Zhangetal.,2005).Th...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期