SuppressionofActivationofSignalTransducerandActivatorofTranscription-BSignalingintheVesselWallReducesBalloonInjury-InducedNeointimaFormatio
...otility.TolearnmoreabouttheroleofSTAT-5Binvesselwallremodeling,weexamineditsinvolvementinplatelet-derivedgrowthfactor-BB(PDGF-BB)-stimulatedVSMCgrowthandmotilityandballooninjury-inducedneointimaformation.PDGF-BBactivatedSTAT-5Basmeasuredbyitstyrosinephosphorylation,DNAbinding,andreportergeneactivity...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第10期BisindenoisoquinolineBis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propanebis(trifluoroacetate)(NSC727357),aDNAInterca
【关键词】BisindenoisoquinolineIndenoisoquinolinesaretopoisomerase(Top)Iinhibitorsdevelopedtoovercomesomeofthelimitationsofcamptothecinsandexpandtheiranticancerspectrum.Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}-propanebis(trifluoroacetate)(NSC727357)isanove...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期NephrinectodomainengagementresultsinSrckinaseactivation,nephrinphosphorylation,Nckrecruitment,andactinpolymerization
1DivisionofNephrology,UniversityofMichiganMedicalSchool,AnnArbor,Michigan,USA.2DepartmentofVeteransAffairs,AnnArbor,Michigan,USA.AbstractAproperlyestablishedandmaintainedpodocyteintercellularjunction,orslitdiaphragm,isanecessarycomponentoftheselectivepermeabilitybarrierofthekidneyglomerulus.Theobser...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期Short-andLong-TermRegulationofAdenylylCyclaseActivityby-OpioidReceptorAreMediatedbyGi2inNeuroblastomaN2ACells
...关键词】Short- Long-TermRegulationActivationoftheopioidreceptorresultsinshort-terminhibitionofintracellularcAMPlevelsfollowedbyreceptordesensitizationandsubsequentincreaseofcAMPabovethecontrollevel(adenylylcyclasesuperactivation).Usingadenovirustodeliverpertussistoxin-insensitivemutantsofthe-s...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期PlacentaGrowthFactorinDiabeticWoundHealing
【摘要】Reducedmicrocirculationanddiminishedexpressionofgrowthfactorscontributetowoundhealingimpairmentindiabetes.Placentagrowthfactor(PlGF),anangiogenicmediatorpromotingpathophysiologicalneovascularization,isexpressedduringcutaneouswoundhealingandimproveswoundclosurebyenhancingangiogenesis.Byus...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第10期RegulationofAutophagybyExtracellularSignal-RegulatedProteinKinasesDuring-Methyl--Phenylpyridinium-InducedCellDeath
...s)occurininjuredordegeneratingneurons,underbothdevelopmentalandpathologicalsituations.Althoughregulationofstarvation-inducedautophagyhasbeenextensivelystudied,lessisknownaboutautophagicresponsestopathologicaldamage.Theneurotoxin1-methyl-4-phenylpyridinium(MPP+)producesmitochondria-targetedinjury,whi...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第1期3-MethylcholanthreneDisplaysDualEffectsonEstrogenReceptor(ER)andERβSignalinginaCell-TypeSpecificFashion
...ceptor(AhR).ActivationofAhRistraditionallyassociatedwithaninhibitionoftheE2signalingnetwork.Inthisstudy,wedemonstratethat3-MCisacell-specificactivatororinhibitorofE2signalingpathways.Weshowthat3-MCactsasarepressorinsomecells,presumablyviatheAhR,whereasitisapotentactivatorofERactivityinothercells.Iti...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期Phosphoinositide-dependentkinase1targetsproteinkinaseAinapathwaythatregulatesinterleukin4
...lMedicalResearchCenterforArthritisandtheHowardHughesMedicalInstitute,UniversityofCaliforniaatSanFrancisco,CA94143CD28playsacriticalroleinTcellimmuneresponses.AlthoughthekinaseAkthasbeenshowntoactdownstreamofCD28inThelper(Th)1cytokineinduction,itdoesnotinduceTh2cytokinessuchasinterleukin4(IL-4).Werec...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期GangliosidesTriggerInflammatoryResponsesviaTLRinBrainGlia
【摘要】Gangliosidesparticipateinvariouscellulareventsofthecentralnervoussystemandhavebeencloselyimplicatedinmanyneuronaldiseases.However,theprecisemolecularmechanismsunderlyingthepathologicalactivityofgangliosidesarepoorlyunderstood.Herewereportthattoll-likereceptor4(TLR4)maymediatethegangliosi...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第5期ImpactoftheLossofHoxaFunctiononLungAlveogenesis
【摘要】Theinvolvementofgenescontrollingembryonicprocessesintheetiologyofdiseasesoftenescapesattentionbecauseofthefocusgiventotheirinherentdevelopmentalrole.Hoxa5belongstotheHoxgenefamilyencodingtranscriptionfactorsknownfortheirroleinskeletalpatterning.Hoxa5isrequiredforembryonicrespiratorytract...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第10期