PositiveSelectionofAnti–Thy-1AutoreactiveB-1CellsandNaturalSerumAutoantibodyProductionIndependentfromBoneMarrowBCellDevelopment
...)isproducedbyB-1cellsthatarepositivelyselectedbyself-antigen.Here,usingATAµtransgenicmiceweshowthatcellswiththisBcellreceptorarenegativelyselectedduringbonemarrow(BM)development.InaThy-1nullenvironment,BMATABcellsprogresstoanormalfollicularstageinspleen.However,inaself-antigen–positiveenviro...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第1期短期应用尼尔雌醇对绝经妇女生殖系统的影响
...iveInvestigatingtheeffectofshort-termuseofNilestriolonthefemalegenitalsystemincludingthevagina,cervix,uterusandovariesofpostmenopausalwomen.MethodsTheHTgroupandthecontrolgroupwerestudiedinthispaper.AllofthewomenacceptedaseriesofexaminationforevaluatingtheeffectofNilestriol.Bloodsamplesweretakenf...
医源资料库;在线期刊;中华医学实践杂志;2006年第5卷第7期DecreasedPlasmaFibronectinLeadstoDelayedThrombusGrowthinInjuredArterioles
...ofthedecreaseinplasmaFN(pFN),theroleofFNsplicevariantsinthrombosis,andtoexaminewhetherpFNincorporatesintothrombiinvivo.MethodsandResults-WecomparedthethromboticresponsetoavesselinjuryinFNheterozygous(FN+/-)miceandcorrespondingFN+/+mice.Althoughnormalthrombosisinvenuleswasobserved,adecreasetohalfinth...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第6期AConstitutivelyActiveHypoxia-InducibleFactor-1/VP16HybridFactorActivatesExpressionoftheHumanB-TypeNatriureticPeptideGene
...nBNPgeneexpressionintheseanalyses,themechanismoftheHIF-1/VP16effectwasdetermined.Analysesofpromoterdeletionmutantssuggestedthatthecis-actingsequenceinthehumanBNPpromotermediatingactivationbyHIF-1/VP16wasaputativeHIF-1responsiveelement(HRE)locatedat-466.AnSV40basalpromoter-luciferaseplasmidcontaining...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期UncouplingProteinHasProtectiveFunctionduringExperimentalAutoimmuneEncephalomyelitis
【摘要】Uncouplingprotein2(UCP2)isamemberofthemitochondrialtransportersuperfamilythatisexpressedinmanytissues,includingimmunecells.UCP2preventsoxidativestressbyreducingreactiveoxygenspecies.UsingUCP2-deficientmice,itwasshownthatUCP2isinvolvedintheregulationofinsulinsecretion,intheresistancetoinf...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第5期InducedSputum8-IsoprostaneConcentrationsinInflammatoryAirwayDiseases
...centrationsmaybeausefulmarkerofoxidativestressinairwaysdisease.Thisstudyexaminesoxidativestress(measuredby8-iso-PGF2)inairwaydiseaseaccordingtodiseasetype(asthmaandbronchiectasis),diseaseactivity(stableandacuteasthma),anddiseasepattern(intermittent,mild,moderate,andseverepersistentasthma).Wecompared...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第3期RoleofBreastCancerResistanceProtein(Bcrp1/Abcg2)intheExtrusionofGlucuronideandSulfateConjugatesfromEnterocytestoIntestinalLumen
...ancerInstitute,Amsterdam,TheNetherlandsAbstractThepurposeofthisstudyistoexaminethesignificanceofeffluxtransportersinthesmallintestinetoextrudeglucuronide(G)andsulfate(S)conjugatesintotheintestinallumen.Fromthisstandpoint,weperformedinsituintestinalperfusionexperimentsbyusingEisaihyperbilirubinemicra...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第3期NonalcoholicFattyLiverDiseaseIsAssociatedWithCarotidAtherosclerosis
AngelBrea;DanielMosquera;EvaMartín;AnaArizti;JoséL.Cordero;EmilioRosFromtheLipidClinic,InternalMedicineService(A.B.,D.M.,E.M.,A.A.)andRadiologyService(J.L.C.),HospitalSanMillán-SanPedro,Logro?o,Spain;andLipidClinic,EndocrinologyandNutritionService,Institutd’InvestigacionsBiomèdiquesAugustPiSun...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第5期InterrelationshipsBetweenHumanApolipoproteinA-IandApolipoproteinsB-48andB-100KineticsUsingStableIsotopes
...ofWesternAustralia,Perth,Australia.ABSTRACTObjective—Ourpurposewastodeterminetherelationshipbetweenapolipoprotein(apo)A-IandapoB-48andapoB-100metabolisminmoderatelyhypercholesterolemichumans.MethodsandResults—ThekineticsofapoA-Iwithinhigh-densitylipoprotein(HDL),apoB-48andapoB-100withintriglycer...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第9期Flavorvarietyenhancesfoodacceptanceinformula-fedinfants
CarolynJGerrishandJulieAMennella1FromtheMonellChemicalSensesCenter,Philadelphia.2SupportedbygrantsHD37119andHD08428fromtheNationalInstitutesofHealthandbyagrantfromtheGerberCompaniesFoundation.TheGerberProductsCompanysuppliedthebabyfoodsusedinthisstudy.3AddressreprintrequeststoJAMennella,3500MarketSt...
医源资料库;在线期刊;美国临床营养学杂志;2001年73卷第6期