Lysophosphatidicacidinhibitscholeratoxin-inducedsecretorydiarrheathroughCFTR-dependentproteininteractions
1DepartmentofPhysiology,UniversityofTennesseeHealthScienceCenter,Memphis,TN381632DepartmentofComparativeMedicine,UniversityofTennesseeHealthScienceCenter,Memphis,TN381633DepartmentofNeurobiology,PharmacologyandPhysiology,TheUniversityofChicago,Chicago,IL60637Thecysticfibrosistransmembraneconductance...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第7期IntestinalABCA1directlycontributestoHDLbiogenesisinvivo
...apeutics,ChildandFamilyResearchInstitute,DepartmentofMedicalGenetics,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada.2CenterforLiver,DigestiveandMetabolicDiseases,LaboratoryofPediatrics,UniversityMedicalCenterGroningen,Groningen,TheNetherlands.3DepartmentofAnatomyandCellBiology,StateUni...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第4期NotchSignalingInducesApoptosisandInhibitsHumanMDA-MB-XenograftGrowth
...】Notchfunctionsasanoncogeneortumorinhibitorinvariouscancers,anddecreasesinNotch2expressionareassociatedwithincreasinggradeofhumanbreastcancer.WeconstitutivelyactivatedNotchsignalingwithintracellulardomain(ICD)expressioninthehumanadenocarcinomalineMDA-MB-231.Notch2signalingincreasedapoptosis,wherea...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期InvivoroleofER-associatedpeptidaseactivityintailoringpeptidesforpresentationbyMHCclassIaandclassIbmolecules
1DepartmentofMicrobiologyandImmunology,VanderbiltUniversitySchoolofMedicine,Nashville,TN372322TheJacksonLaboratory,BarHarbor,ME04609Endoplasmicreticulum(ER)-associatedaminopeptidase(ERAP)1hasbeenimplicatedinthefinalproteolyticprocessingofpeptidespresentedbymajorhistocompatibilitycomplex(MHC)classImo...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期RoleofC5inthedevelopmentofairwayinflammation,airwayhyperresponsiveness,andongoingairwayresponse
1AlexionPharmaceuticalsInc.,Cheshire,Connecticut,USA.2DepartmentofPathologyand3DepartmentofInternalMedicine,YaleUniversitySchoolofMedicine,NewHaven,Connecticut,USA.4DepartmentofAnesthesiology,PerioperativeandPainMedicine,BrighamandWomen’sHospital,Boston,Massachusetts,USA.AbstractTheroleofcomplemen...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期TransformingGrowthFactor-ReceptorType1(TGFRI)KinaseActivitybutNotp38ActivationIsRequiredforTGFRI-InducedMyofibroblastDifferentiationandPro
...hfactor-(TGF)isamajormediatorofnormalwoundhealingandofpathologicalconditionsinvolvingfibrosis,suchasidiopathicpulmonaryfibrosis.TGFalsostimulatesthedifferentiationofmyofibroblasts,ahallmarkoffibroticdiseases.Inthisstudy,weexaminedtheunderlyingprocessesofTGFRIkinaseactivityinmyofibroblastconversionof...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期CaMkinaseIIselectivelysignalstohistonedeacetylase4duringcardiomyocytehypertrophy
DepartmentofMolecularBiology,UniversityofTexasSouthwesternMedicalCenter,Dallas,Texas,USA.AbstractClassIIahistonedeacetylases(HDACs)regulateavarietyofcellularprocesses,includingcardiacgrowth,bonedevelopment,andspecificationofskeletalmusclefibertype.Multipleserine/threoninekinasescontrolthesubcellular...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第7期CXCL1inducedbyprostaglandinE2promotesangiogenesisincolorectalcancer
...entalBiologyandPharmacology,5Vanderbilt-IngramCancerCenter,VanderbiltUniversityMedicalCenter,Nashville,TN372326DivisionofPulmonaryandCriticalCareMedicine,DavidGeffenSchoolofMedicine,UniversityofCalifornia,LosAngeles,LosAngeles,CA90095Chronicinflammationisawell-knownriskfactorforcancer.Proinflammator...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期DecreasedExpressionofBmiIsCloselyAssociatedwithCellularSenescenceinSmallBileDuctsinPrimaryBiliaryCirrhosis
...Cellularsenescenceofbiliaryepithelialcellswithp16INK4aandp21WAF1/Cipexpressionindamagedsmallbileductsmaybecriticalforprogressivebileductlossinprimarybiliarycirrhosis.Weinvestigatedtheinvolvementofbmi1,apolycombgroupgenerepressingp16INK4aexpression,inthepathogenesisofbiliarycellularsenescence.Bmi1exp...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期Lightchaineditinggeneratespolyreactiveantibodiesinchronicgraft-versus-hostreaction
1DepartmentofPathology,GwenKnappCenterforLupusandImmunologyResearch,UniversityofChicago,Chicago,IL606372LaboratoryofMolecularGeneticsandImmunology,TheRockefellerUniversity,NewYork,NY10021Thechronicgraft-versus-host(cGvH)reactionisamodelofinducedlupuscausedbyalloreactiveCD4+TcellsfromaBm-12mouseinaC5...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期