DesensitizationoftheDopamineD1andD2ReceptorHetero-OligomerMediatedCalciumSignalbyAgonistOccupancyofEitherReceptor
【关键词】DesensitizationWhendopamineD1andD2receptorswerecoactivatedinD1-D2receptorhetero-oligomericcomplexes,anovelphospholipaseC-mediatedcalciumsignalwasgenerated.Inthisreport,desensitizationofthisGq/11-mediatedcalciumsignalwasdemonstratedbypretreatmentwithdopamineorwiththeD1-selectiveagonist...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期AnUnsuspectedMetabolicRoleforAtrialNatriureticPeptides
...nstitutNationaldelaSantéetdelaRechercheMédicale(Inserm),InsermU586;theObesityResearchUnit;BP84225;31432Toulousecedex4;andtheUniversitéPaulSabatier,31052Toulousecedex4,France.CorrespondencetoDoctorMaxLafontan,IFR-31,InstitutLouisBugnard,ObesityResearchUnit,Inserm-UPSU586,BP84225,31432Toulousecedex...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第10期cAMPInhibitsTransformingGrowthFactor--StimulatedCollagenSynthesisviaInhibitionofExtracellularSignal-RegulatedKinase1/2andSmadSignalinginCard
...forminggrowthfactor-(TGF-)playafundamentalroleinthedevelopmentoftissuefibrosisbystimulatingmatrixdepositionandotherprofibroticresponses,butlessisknownaboutpathwaysthatmightinhibitfibrosis.IncreasedcAMPformationinhibitsmyofibroblastdifferentiationandcollagenproductionbycardiacfibroblasts,butthemechan...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第12期ThehumanmacrophagemannosereceptordirectsMycobacteriumtuberculosislipoarabinomannan-mediatedphagosomebiogenesis
1DivisionofInfectiousDiseases,DepartmentsofInternalMedicineandMolecularVirology,Immunology,andMedicalGenetics,andtheCenterforMicrobialInterfaceBiology,TheOhioStateUniversity,Columbus,OH432102DivisionofInfectiousDiseases,DepartmentsofInternalMedicineandMicrobiology,theImmunologyProgram,andtheVAMedica...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第7期Caveolin-1RegulatesStore-OperatedCa2+InfluxbyBindingofItsScaffoldingDomaintoTransientReceptorPotentialChannel-1inEndothelialCells
...nedtheroleofthecaveolin-1scaffoldingdomain(CSD)inregulatingtheSOC[i.e.,transientreceptorpotentialchannel-1(TRPC1)]inhumanpulmonaryarteryendothelialcells(HPAECs).Weusedthecellpermeantantennapedia(AP)-conjugatedCSDpeptide,whichcompetesforproteinbindingpartnerswithcaveolin-1,toassesstheinteractionsofca...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期RevascularizationofischemictissuesbyPDGF-CCviaeffectsonendothelialcellsandtheirprogenitors
1TheCenterforTransgeneTechnologyandGeneTherapy,FlandersInteruniversitaryInstituteforBiotechnology(VIB),UniversityofLeuven,Leuven,Belgium.2LudwigInstituteforCancerResearch,KarolinskaInstitute,Stockholm,Sweden.3Cardiovascular/ThrombosisResearchDepartment,Sanofi-Aventis,Toulouse,France.4LaboratoiredeBi...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第1期Hemeoxygenase-1isamodulatorofinflammationandvaso-occlusionintransgenicsicklemice
1DivisionofHematology,Oncology,andTransplantation,DepartmentofMedicineandVascularBiologyCenter,UniversityofMinnesota,Minneapolis,Minnesota,USA.2DepartmentofSurgery,HarvardMedicalSchool,BethIsraelDeaconessMedicalCenter,Boston,Massachusetts,USA.AbstractTransgenicsicklemiceexpressing?Shemoglobinhaveact...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期TAT-mediatedintracellulardeliveryofpurinenucleosidephosphorylasecorrectsitsdeficiencyinmice
1Infection,Immunity,InjuryandRepairProgram,ResearchInstitute,and2DivisionofAllergyandClinicalImmunology,HospitalforSickChildrenandUniversityofToronto,Toronto,Ontario,Canada.AbstractDefectsinpurinenucleosidephosphorylase(PNP)enzymeactivityresultinabnormalnucleosidehomeostasis,severeTcellimmunodeficie...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期TGF--activatedkinase1andTAK1-bindingprotein1cooperatetomediateTGF-1-inducedMKK3-p38MAPKactivationandstimulationoftypeIcollagen
...GF-1)rapidlyactivatesthemitogen-activatedproteinkinasekinase3(MKK3)-p38MAPKsignalingcascade,leadingtotheinductionoftypeIcollagensynthesisinmouseglomerularmesangialcells(WangL,MaR,FlavellRA,ChoiME.JBiolChem277:47257-47262,2002).Inthepresentstudy,weinvestigatedthefunctionalroleofupstreamTGF--activated...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第5期Alterationsinregulationofenergyhomeostasisincyclicnucleotidephosphodiesterase3B–nullmice
...IH,Bethesda,Maryland,USA.2DepartmentofExperimentalMedicalScience,LundUniversity,Lund,Sweden.3DiabetesBranch,NIDDK,NIH,Bethesda,Maryland,USA.Addresscorrespondenceto:YoungHunChoi,PCCMB,NHLBI,NIH,9000RockvillePike,Building10,Room5N307,Bethesda,Maryland20892,USA.Phone:(301)402-4774;Fax:(301)402-1610;E-m...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第12期