IdentificationandCharacterizationofTwoAminoAcidsCriticalfortheSubstrateInhibitionofHumanDehydroepiandrosteroneSulfotransferase(SULT2A1)
...FH,and1OV4,respectively)haveenabledustoelucidatethespecificaminoacidsresponsibleforsubstrateinhibition.Basedonthestructuralanalyses,substitutionofthesmallerresiduealanineforTyr-238(Y238A)significantlyincreasestheKivaluefordehydroepiandrosterone(DHEA)andtotallyeliminatessubstrateinhibitionforandroste...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期InnateNKTlymphocytesconfersuperioradaptiveimmunityviatumor-capturingdendriticcells
1LaboratoryofCellularPhysiologyandImmunology,TheRockefellerUniversity,NewYork,NY100212InstitutoLeloir,InstitutodeInvestigacionesBioquimicas3DepartamentodeQuímicaBiológica,FacultaddeCienciasExactasyNaturales,UniversidaddeBuenosAires,1650BuenosAires,Argentina4DivisionofCancerImmunology,DepartmentofP...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第11期MolecularDeterminantsofPyrantelSelectivityinNicotinicReceptors
...ularDeterminantsNicotinicreceptors(acetylcholinereceptors,AChRs)playkeyrolesinsynaptictransmissionthroughoutthenervoussystem.AChRsmediateneuromusculartransmissioninnematodes,andtheyaretargetsforantiparasiticdrugs.Theanthelminticagentslevamisoleandpyrantel,whicharepotentagonistsofnematodemuscleAChRs,...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期NeurotoxicityofDomoicAcidinCerebellarGranuleNeuronsinaGeneticModelofGlutathioneDeficiency
...rotoxicityThisstudyinvestigatedtheroleofcellularantioxidantdefensemechanismsinmodulatingtheneurotoxicityofdomoicacid(DomA),byusingcerebellargranuleneurons(CGNs)frommicelackingthemodifiersubunitofglutamate-cysteineligase(Gclm).Glutamate-cysteineligase(Glc)catalyzesthefirstandrate-limitingstepinglutat...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第12期GeneExpressionChangesduringtheDevelopmentofAcuteLungInjuryRoleofTransformingGrowthFactor
DepartmentofEnvironmentalHealth,CenterforEnvironmentalGenetics,andDivisionofPulmonaryandCriticalCareMedicine,DepartmentofInternalMedicine,UniversityofCincinnatiMedicalCenter,UniversityofCincinnati,Cincinnati,OhioABSTRACTRationale:Acutelunginjurycanoccurfrommultiplecauses,resultinginhighmortality.The...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第12期Galectin-AssociateswiththePrimaryCiliumandModulatesCystGrowthinCongenitalPolycysticKidneyDisease
【摘要】Severallinesofevidenceimplicatetheß-galactoside-bindinglectingalectin-3indevelopmentandpathologicalprocessesinrenalcollectingducts:galectin-3isexpressedintheuretericbud/collectingductlineageduringnephrogenesis,modulatescollectingductgrowth/differentiationinvitro,andisexpressedinhum...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期NF-BregulationofendothelialcellfunctionduringLPS-inducedtoxemiaandcancer
...ofMicrobiology,2DepartmentofMedicine,and3DepartmentofPathology,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,NewYork,NewYork,USA.AbstractThetranscriptionfactorNF-Bisanimportantregulatorofhomeostaticgrowthandinflammation.Althoughgene-targetingstudieshaverevealedimportantrolesforNF-B,theyhavebeenc...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期LocalapplicationofFTY720tothelungabrogatesexperimentalasthmabyalteringdendriticcellfunction
1DepartmentofPulmonaryMedicine,ErasmusUniversityMedicalCenter,Rotterdam,TheNetherlands.2DepartmentofPneumology,UniversityofFreiburg,Freiburg,Germany.AbstractAirwayDCsplayacrucialroleinthepathogenesisofallergicasthma,andinterferingwiththeirfunctioncouldconstituteanovelformoftherapy.Thesphingosine1–...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期第14届国际HIV药物耐药会议(2005-7)
第14届国际HIV药物耐药会议HighlightsoftheXIVInternationalHIVDrugResistanceWorkshop2005年7月7-11日加拿大魁北克July7-11,2005,QuebecCity,Quebec,CanadaAntiretroviralDrugResistance:MuchMoreCommonThanWeThoughtWilliamO‘Brien,MDIntroduction:The14thInternationalHIVDrugResistanceWorksh...
医学教育;学术活动RegulationofTypeIICollagenSynthesisduringOsteoarthritisbyProlyl--Hydroxylases
...eoarthritic(OA)chondrocytesaremetabolicallyactive,displayingincreasedsynthesisoftypeIIcollagen.Here,weshowbyimmunohistochemistryandpolymerasechainreactionthatincomparisonwithhealthycartilage,OAarticularchondrocytesexhibitincreasedinvivosynthesisofcollagenprolyl-4-hydroxylasetypeII,apivotalenzymeinco...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期