SignalTransducerandActivatorofTranscriptionbPromotesMucosalToleranceinPediatricCrohn??sDiseaseandMurineColitis
...PPAR)suppressesmucosalinflammationandisregulatedbyGHthroughSTAT5b.WehypothesizedthattheGH:STAT5baxisinfluencessusceptibilitytocolitisviaregulationoflocalPPARabundance.ColonbiopsiesfromchildrenwithnewlydiagnosedCrohn??sdisease(CD)andcontrolswereexposedtoGHinshort-termorganculture.Trinitrobenzenesulfo...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期ScavengerReceptorsinAtherosclerosis
【摘要】Atheroscleroticvasculardiseasearisesasaconsequenceofthedepositionandretentionofserumlipoproteinsinthearterywall.Macrophagesinlesionshavebeenshowntoexpress6structurallydifferentscavengerreceptorsforuptakeofmodifiedformsoflow-densitylipoproteins(LDLs)thatpromotethecellularaccumulationofcho...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第8期EphA2:expressionintherenalmedullaandregulationbyhypertonicityandureastressinvitroandinvivo
【关键词】medullaDivisionofNephrologyandHypertension,OregonHealth&ScienceUniversityandthePortlandVeteransAffairsMedicalCenter,Portland,OregonSectionofNephrology,DepartmentofMedicine,BostonUniversitySchoolofMedicineandBostonMedicalCenter,Boston,MassachusettsDepartmentofPathology,JohnsHopkinsUniv...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第4期TargetGenesofNeuron-RestrictiveSilencerFactorAreAbnormallyUp-RegulatedinHumanMyotilinopathy
...摘要】Myotilinopathyisasubgroupofmyofibrillarmyopathiescausedbymutationsinthemyotilingeneinwhichthereisaggregationofabnormalcytoskeletalproteinsandubiquitin.Wereporthereontheaccumulationofneuron-relatedproteinssuchasubiquitincarboxy-terminalhydrolaseL1(UCHL1),synaptosomal-associatedprotein25,syna...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第10期Platelet-ActivatingFactorIsCrucialinPsoralenandUltravioletA-InducedImmuneSuppressionInflammationandApoptosis
...A)isusedasaveryeffectivetreatmentmodalityforvariousdiseases,includingpsoriasisandcutaneousT-celllymphoma.PUVA-inducedimmunesuppressionand/orapoptosisarethoughttoberesponsibleforthetherapeuticaction.However,themolecularmechanismsbywhichPUVAactsarenotwellunderstood.Wehavepreviouslyidentifiedplatelet-a...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期BrainCholesterol:LongSecretLifeBehindaBarrier
FromtheDivisionofClinicalChemistry,KarolinskaInstitute,HuddingeUniversityHospital,Stockholm,Sweden.ABSTRACTAlthoughanimmenseknowledgehasaccumulatedconcerningregulationofcholesterolhomeostasisinthebody,thisdoesnotincludethebrain,wheredetailsarejustemerging.Approximately25%ofthetotalamountofthecholest...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第5期ActivatedmacrophagesareessentialinamurinemodelforTcell–mediatedchronicpsoriasiformskininflammation
1DepartmentofDermatologyandAllergicDiseases,UniversityofUlm,Ulm,Germany.2DepartmentofCellBiology,FreeUniversity,Amsterdam,TheNetherlands.3DepartmentofDermatologyandCenterforMolecularMedicine,UniversityofCologne(CMMC),Cologne,Germany.AbstractTheCD18hypomorphic(CD18hypo)PL/Jmousemodelclinicallyresembl...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第8期MinimalLipidationofPre-ßHDLbyABCA1ResultsinReducedAbilitytoInteractwithABCA
...minetheroleofATPbindingcassettetransporterA1(ABCA1)ongenerationofdifferent-sizednascentHDLs.MethodsandResults-HEK293cellsstably-transfectedwithABCA1(HEK293-ABCA1)ornon-transfected(control)cellswereincubatedwithlipidfree125I-apoA-Ifor24hours.IncubationofapoA-IwithHEK293-ABCA1cells,butnotcontrolcells,...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第8期Ligationofprotease-activatedreceptor1enhancesv?6integrin-dependentTGF-?activationandpromotesacutelunginjury
...enter,UCSF,SanFrancisco,California,USA.2CentreforRespiratoryResearch,UniversityCollegeLondon,London,UnitedKingdom.3CardiovascularResearchInstitute,UCSF,SanFrancisco,California,USA.4DepartmentofPathologyandLaboratoryMedicine,TexasAMUniversitySystemHealthScienceCenter,CollegeStation,Texas,USA.Abstract...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期ImportanceofintegrinLFA-1deactivationforthegenerationofimmuneresponses
1DepartmentofSurgery,Immunology,andHygiene,TechnischeUniversittMünchen,81675Munich,Germany2InstituteofMedicalMicrobiology,Immunology,andHygiene,TechnischeUniversittMünchen,81675Munich,Germany3CancerResearchUK,LondonResearchInstitute,LondonWC2A3PX,England,UK4InstituteofMedicalMicrobiology,Universit...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第12期