AcinarCellsContributetotheMolecularHeterogeneityofPancreaticIntraepithelialNeoplasia
...tudieshaveshownthatpancreaticductaladenocarcinomadevelopsthroughprecursorlesionstermedpancreaticintraepithelialneoplasia(PanIN).PanINsarethoughttoinitiateinthesmallductsofthepancreasthroughactivatingmutationsintheKRASproto-oncogene.Whatremainsunansweredistheidentificationoftheindividualcelltype(s)th...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第7期CD4–CD8–Tcellscontrolintracellularbacterialinfectionsbothinvitroandinvivo
...ministration,Rockville,MD208522DepartmentofMicrobiologyandImmunology,UniversityofNorthCarolina,ChapelHill,ChapelHill,NC275993CenterforImmunology,UniversityofTexasSouthwesternMedicalCenter,Dallas,TX75390MemoryTcells,includingthewell-knownCD4+andCD8+Tcells,arecentralcomponentsoftheacquiredimmunesystem...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第2期OngoingCoxsackievirusMyocarditisIsAssociatedwithIncreasedFormationandActivityofMyocardialImmunoproteasomes
...eofviralmyocarditis.Susceptiblemousestrainsdevelopchronicmyocarditisonthebasisofrestrictedviralreplication,whereasresistantstrainsrecoveraftersuccessfulviruselimination.Incomparativewhole-genomemicroarrayanalysesofinfectedhearts,severalgenesinvolvedintheprocessingandpresentationofviralepitopeswerefo...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第5期AmutationintheIcsbp1genecausessusceptibilitytoinfectionandachronicmyeloidleukemia–likesyndromeinBXH-2mice
1DepartmentofBiochemistry,McGillCancerCenter2CenterfortheStudyofHostResistance,DepartmentofHumanGenetics,McGillUniversity,Montreal,QuebecH3G1Y6,Canada3BiotechnologyResearchInstitute,Montreal,QuebecH4P2R2,CanadaBXH-2micedevelopafatalmyeloidleukemiabyatwo-stepmutagenicprocess.First,aBXH-2–specificre...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第6期Selectivetyrosinekinaseinhibitionbyimatinibmesylateforthetreatmentofautoimmunearthritis
1DivisionofImmunologyandRheumatology,DepartmentofMedicine,StanfordUniversitySchoolofMedicine,Stanford,California,USA.2GeriatricResearch,Education,andClinicalCenter,PaloAltoVAHealthCareSystem,PaloAlto,California,USA.3DepartmentofNeurologyandNeurologicalSciences,4DepartmentofPathology,and5Departmentof...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期SuppressionofhREV1ExpressionReducestheRateatWhichHumanOvarianCarcinomaCellsAcquireResistancetoCisplatin
DepartmentofMedicineandtheRebeccaandJohnMooresCancerCenter,UniversityofCalifornia,SanDiego,LaJolla,CaliforniaAbstractReplicativebypassofmanyDNAadductsisdependentontheinteractionofhREV1withDNApolymeraseandpotentiallywithmembersoftheYfamilyofDNApolymerases.ToexaminetheroleofhREV1inthedevelopmentofcisp...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第6期MAPkinasesandtheadaptiveresponsetohypertonicity:functionalpreservationfromyeasttomammals
【摘要】Theadaptationtohypertonicityinmammaliancellsisdrivenbymultiplesignalingpathwaysthatincludep38kinase,Fyn,thecatalyticsubunitofPKA,ATM,andJNK2.Inadditiontothewell-characterizedtonicityenhancer(TonE)-TonEbindingproteininteraction,othertranscriptionfactors(andtheirrespectiveciselements)canpo...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第12期Genetherapytargetingsurvivinselectivelyinducespulmonaryvascularapoptosisandreversespulmonaryarterialhypertension
1TheVascularBiologyGroupandPulmonaryHypertensionProgram,UniversityofAlberta,Edmonton,Alberta,Canada.2DepartmentofCancerBiologyandtheCancerCenter,UniversityofMassachusettsMedicalSchool,Worcester,Massachusetts,USA.3DepartmentofPathology,UniversityofAlberta,Edmonton,Alberta,Canada.AbstractPulmonaryarte...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期TheTelomericProteinTRF2IsCriticalfortheProtectionofA549CellsfromBothTelomereErosionandDNADouble-StrandBreaksDrivenbySalvicine
【关键词】TelomericTelomererepeatbindingfactor2(TRF2)hasbeenincreasinglyrecognizedtobeinvolvedinDNAdamageresponseandtelomeremaintenance.Ourpreviousreportfoundthatsalvicine(SAL),anoveltopoisomeraseIIpoison,elicitedDNAdouble-strandbreaksandtelomereerosioninseparateexperimentalsystems.However,itre...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期Protectionoftransplant-inducedrenalischemia-reperfusioninjurywithcarbonmonoxide
...mbyhemeoxygenases,isknowntoimpartprotectionagainstoxidativestress.WehypothesizedthatCOwouldprotectischemia-reperfusion(I/R)injuryoftransplantedorgans,andtheefficacyofCOwasstudiedintheratkidneytransplantationmodel.ALewisratkidneygraft,preservedinUniversityofWisconsinsolutionat4°Cfor24h,wasorthoto...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第11期