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Antibodyisotype-specificengagementofFcreceptorsregulatesBlymphocytedepletionduringCD20immunotherapy
...bulin(Ig)GFcreceptor(FcR)-dependentpathwayswithahierarchyofIgG2a/cIgG1/IgG2bIgG3.TounderstandthemolecularbasisfortheseCD20mAbsubclassdifferences,BcelldepletionwasassessedinmicedeficientorblockedforstimulatoryFcRI,FcRIII,FcRIV,orFcRcommonchain,orinhibitoryFcRIIB.IgG1CD20mAbsinducedBcelldepletionthrou...
医源资料库；在线期刊；实验医学杂志；2006年第203卷第3期 -
参麦注射液治疗脑卒中的临床观察
...心房纤颤30例（31.25%），风湿性心脏病20例（20.8%），高血压68例（70.8%）。根据临床症状及头颅CT检查诊断为脑卒中，诊断标准参照1996年全国第四届脑血管会议制定的标准［1］。临床症状有头晕、头痛、呕吐、失语、失算、失认...
合作平台；在线期刊；中华中西医杂志；2004年第5卷第12期；论著 -
DevelopmentofaQuantitativeReal-TimePCRAssayforDetectionofMycoplasmagenitalium
DepartmentofMedicalMicrobiologyandImmunology,TheBartholinBuilding,AarhusUniversity,DK-8000AarhusC,DenmarkMycoplasmaLaboratory,StatensSerumInstitut,DK-2300CopenhagenS,DenmarkDepartmentofDermatovenereology,HuddingeUniversityHospital,KarolinskaInstitutet,S-14186Huddinge,SwedenABSTRACTMycoplasmagenitali...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第7期 -
胆囊结石成因的研究进展
...运至肝脏代谢。参与该摄取过程的是肝脏清道夫受体(SR2BI)，研究表明SR2BI在调节血脂过程中具有重要作用，它和胆石病的关系正受到关注［10］。当小鼠肝脏过度表达该受体时，血浆中HDL受体含量降低，而胆汁中胆固醇含量升高...
医源资料库；在线期刊；局解手术学杂志；2009年第18卷第1期 -
MultilocusSequenceTypingofMethicillin-ResistantStaphylococcusaureusfromanAreaofLowEndemicitybyReal-TimePCR
DepartmentsofClinicalMicrobiologyInfectiousDiseases,rebroUniversityHospital,SE-70185rebro,SwedenABSTRACTAprotocolformultilocussequencetyping(MLST)ofmethicillin-resistantStaphylococcusaureus(MRSA)wasadaptedtoreal-timeLightCyclerSystemPCRforefficientandrapidamplificationofsevenhousekeepinggenesinthesa...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第9期 -
LiverXreceptorsasintegratorsofmetabolicandinflammatorysignaling
...yresponsesinmacrophages.SyntheticLXRagonistspromotecholesteroleffluxandinhibitinflammationinvivoandinhibitthedevelopmentofatherosclerosisinanimalmodels.TheabilityofLXRstointegratemetabolicandinflammatorysignalingmakesthemparticularlyattractivetargetsforinterventioninhumanmetabolicdisease.LiverXrecep...
医源资料库；在线期刊；临床研究杂志；2006年第116卷第3期 -
ThenucleocytoplasmicshuttlingproteinCIZreducesadultbonemassbyinhibitingbonemorphogeneticprotein–inducedboneformation
...y.TheseresultsestablishthatCIZsuppressesthelevelsofadultbonemassthroughinhibitionofBMP-inducedactivationofosteoblasts.Abbreviationsused:ALP,alkalinephosphatase;BMP,bonemorphogeneticprotein;CIZ,Cas-interactingzincfingerprotein;COL,typeIcollagen;LRP5,low-densitylipoproteinreceptor-relatedprotein5;OPN,...
医源资料库；在线期刊；实验医学杂志；2005年第201卷第6期 -
速碧林TM治疗急性脑梗死48例临床观察
...排除标准 （1）明确为心源性脑梗死者;（2）严重高血压，收缩压200.8mmHg（1mmHg=0.133kPa），舒张压110.5mmHg者;（3）伴心房纤颤或严重心功能不全者;（4）伴消化道溃疡或有消化道出血病史者;（5）伴严重糖尿病（空腹血糖11.2mmol/L...
合作平台；在线期刊；中华现代临床医学杂志；2005年第3卷第13期 -
Identificationof43StreptococcusSpeciesbyPyrosequencingAnalysisofthernpBGene
DepartmentofClinicalMicrobiology,UppsalaUniversityHospital,SE-75185Uppsala,SwedenBiotageAB,Kungsgatan76,SE-75318Uppsala,SwedenABSTRACTPyrosequencingtechnologywasevaluatedforidentificationofspecieswithintheStreptococcusgenus.TwovariableregionsinthernpBgene,whichencodestheRNAsubunitofendonucleaseP,wer...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第12期 -
Absenceofghrelinprotectsagainstearly-onsetobesity
...animportantroleforendogenousghrelininthemetabolicadaptationtonutrientavailability.SeetherelatedCommentarybeginningonpage3393IntroductionGhrelinisa28-aapeptideproducedpredominantlybythestomachandistheendogenousligandforthegrowthhormonesecretagoguereceptor(GHSR)(1).Inadditiontopotentlystimulatinggrowt...
医源资料库；在线期刊；临床研究杂志；2005年第115卷第12期