Inbornerrorsofimmunitytoinfection:theruleratherthantheexception
...unctionistoprotectagainstmicroorganisms,butinfectionisnonethelessthemostfrequentcauseofdeathinhumanhistory.Untilthelastcentury,lifeexpectancywasonly25years.Recentincreasesinhumanlifespanprimarilyreflectthedevelopmentofhygiene,vaccines,andanti-infectiousdrugs,ratherthantheadjustmentofourimmunesystemt...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第2期两个物理问题与心血管疾病的关系探讨
...气体分压升高,气蚀余量减少。可设动脉血内的O含量为Q,其中游离O为s,结合O为q,O分压为p,溶解度为k,根据乌拉尔定律得s=p*k。则Q=s+q=p*k+q(2)对两边对温度T求导并整理得:dp/dT=-pdk/kdT-dq/kdt(3)由于q为s数十倍,且k的...
合作平台;医学论文;外科论文;心脏外科学Dualspecificityphosphatase1(DUSP1)regulatesasubsetofLPS-inducedgenesandprotectsmicefromlethalendotoxinshock
...tivatecytokinegeneexpression.Abalancedresponsetosignalsofinfectiousdangerrequiresthatcellularactivationistransient.Here,weidentifytheMAPKphosphatasedualspecificityphosphatase1(DUSP1)asanessentialendogenousregulatoroftheinflammatoryresponsetolipopolysaccharide(LPS).DUSP1-deficient(DUSP1–/–)bonema...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期Pagetdiseaseofbone
...athwayscanbeactivated,includingNF-B,AKT,JNK,p38MAPK,andERK,resultinginsubsequentactivationofgenesthatregulateosteoclastformation,boneresorption,andsurvival.TRAF6appearstoplayacentralroleintheactivationofmostofthesepathways.AP1,activatorprotein1;aPKC,atypicalPKC;IB,inhibitorofB;ASK1,apoptosissignal...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第2期LowConcentrationsofNitricOxideExertaHormeticEffectonMycobacteriumtuberculosisInVitro
...snewfindingsuggeststhatRNIexertahormeticeffectonM.tuberculosisinvitro.Consequently,ahormeticresponsetolowconcentrationsofRNImayplayaroleintheabilityofM.tuberculosistopersistforextendedperiodsoftimewithinthehost.TheM.tuberculosisisolatesusedinthisstudywereobtainedfromtuberculosis(TB)patientsthroughou...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期Gadd45andGadd45arecriticalforregulatingautoimmunity
...n;PAMP,pathogen-associatedmolecularpattern.L.Liu,E.Tran,andB.Lucontributedequallytothiswork.Gadd45andGadd45arecriticalfortheinitiationoftheTh1typeresponseandtheyfunctionaspartoftheimmuneresponsethatcombatsintracellularpathogens.Gadd45expressionisinducedinDCsandmacrophagesbypathogen-associatedmolecul...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第10期OligonucleotideLigationAssayforDetectionofMutationsAssociatedwithReverseTranscriptaseandProteaseInhibitorResistanceinNon-BSubtypesandRecomb
...danddevelopedfornon-Bsubtypesandrecombinantstrainsandhasbeenevaluatedwithsequencing,resultinginamoresensitiveassaythansequencingfornon-Bsubtypes.TEXTMethodstoidentifyresistancemutationsinthehumanimmunodeficiencyvirustype1(HIV-1)polgeneareneededsincetheuseofprotease(PR)and/orreversetranscriptase(RT)i...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第10期HelperTcelldifferentiationentersanewera:LeRoiestmort;viveleRoi!
...ellularpathogens,whereaseradicationofhelminthicinfestationsisdependentonadequateTh2responses.However,theimmunopathogenesisofautoimmunediseasedoesnotfitquitesoneatlyintothisdichotomy.CD4+TcellscanalsodifferentiateintocellsthatproducetheimmunosuppressivecytokinesIL-10andTGF,so-calledTh3cells,andcanbec...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期ValidationofPerformanceofPlasticversusGlassBottlesforCulturingAnaerobesfromBloodinBacT/ALERTSNMedium
...xineHCl,andsodiumpyruvate.Thebottlehasasmallerstopperandcontainsamodifiedliquidemulsionsensortoreducetheriskoffalse-positivebottles.Toassesstheresultofthesechanges,wecomparedthenewPSNbottletotheexistingGSNbottlewhenusedinconjunctionwithanaerobicSAbottleforboththerecoveryofmicroorganismsandthetimetod...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期SingleNucleotidePolymorphismsintheHumanNorepinephrineTransporterGeneAffectExpression,Trafficking,AntidepressantInteraction,andProteinKinaseC
...videnceofitsdysfunctionindisease,anditsroleasatargetfortherapeuticsraisethequestionofwhetheralterationsinNEhomeostasisordrugresponsederivefromhNETgeneticvariation.AnumberofhNETpromoter,intron,andcoding-regionpolymorphismshavebeenidentifiedeitherthroughdiscovery-orientedstudiesofhNETinvariousclinical...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第2期