TheadaptormoleculesLATandSLP-76arespecificallytargetedbyYersiniatoinhibitTcellactivation
...ells;MCC,mothcytochromec;MOI,multiplicityofinfection;PH,pleckstrinhomology;PI3K,phosphoinositide3–kinase;SLAP-130,SLP-76–associatedphosphoproteinof130kD;SLP-76,SH2-domain–containingleukocyteproteinof76kD;YFP,yellowfluorescentprotein.Thesuccessofapathogeninestablishinganinfectionisdependentonit...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期TheTransformingGrowthFactor-SuperfamilyMemberGrowth-DifferentiationFactor-15ProtectstheHeartFromIschemia/ReperfusionInjury
...rmanentcoronaryarteryligation.MyocardialGDF-15mRNAandpro-peptideabundancerapidlyincreasedinthearea-at-riskafterischemicinjury.Similarly,patientswithanacutemyocardialinfarctionhadenhancedmyocardialGDF-15pro-peptideexpressionlevels.Asshownbyimmunohistochemistry,cardiomyocytesintheischemicareacontribut...
医源资料库;在线期刊;循环研究杂志;2006年第96卷第2期应重视胸腔积液生化检查
...,供临床医生及同道参考。 1总蛋白40g/L,肿瘤感染性渗出液总蛋白可<40g/L,其灵敏度可达100%。也可通过计算积液与血清总蛋白比值鉴别其性质。 2蛋白电泳 chen等[1]报道,将蛋白质区带电泳运用到积液性质鉴别中...
医源资料库;在线期刊;中国民康医学;2009年第21卷第9期Trendsinwaist-to-hipratioanditsdeterminantsinadultsinFinlandfrom1987to
MarjaanaLahti-Koski,PirjoPietinen,SatuMännistöandErkkiVartiainen1FromtheDepartmentofNutrition,theDepartmentofEpidemiologyandHealthPromotion,NationalPublicHealthInstitute,Helsinki.2SupportedbytheJuhoVainioFoundation.3AddressreprintrequeststoMLahti-Koski,DepartmentofNutrition,NationalPublicH...
医源资料库;在线期刊;美国临床营养学杂志;2000年72卷第6期II型α亚型磷脂酰肌醇-4-激酶的结构功能研究获得突破
图a,hPI4KIIα催化核心ADP结合状态整体结构;图b,ATP结合口袋ADP与hPI4KIIα的相互作用;图c,ATP结合口袋重要氨基酸残基突变体激酶活性;图d,基于分子动力学模拟推测的PI结合口袋;图e,棕榈酰化插入片段突变体激酶活性测定...
医药经济;生物技术;技术要闻LesionPatternsandStrokeMechanisminAtheroscleroticMiddleCerebralArteryDisease
...ionpatternswereclassifiedas(1)single(smallperforator2cm;largeperforator2cm;pial;largeterritorial;border-zone)and(2)multiple.ResultsMCAdiseasewasdiagnosedin63patients,32(50.8%)ofwhomshowedmultiplelesions.Concomitantperforatorandpialinfarcts(14/63,P0.001),concomitantperforator,pial,andborder-zoneinfar...
医源资料库;在线期刊;中风学杂志;2005年第36卷第12期胰腺癌的靶点治疗
...ncreatictumornormallyislethalanddifficulttotreat.Survivalhasnotimproved,despiteroutineuseofchemotherapyandradiotherapy;thissituationsignifiesanurgentneedfornewtherapeuticapproaches.Overthepastdecade,alargenumberofstudiesthataimedtotargetthemolecularabnormalitiesimplicatedinpancreatictumorgrowth,inva...
医源资料库;在线期刊;中华实用医药杂志;2010年第10卷第6期医科院召开PI年中汇报评估会
上海交通大学医学科学研究院PI年中汇报评估会于6月30日上午在西院图书馆底楼演讲厅召开,此次评估会采取了PI口头汇报、PI互评的方式进行考核,同时邀请了“985”创新工程监理汤雪明教授、周光炎教授作为专家进行点评,医...
医学教育;校园动态;上海交通大学医学院AntiangiogenicActivityofaDomainDeletionMutantofTissuePlasminogenActivatorContainingKringle2
...eWeatherallInstituteofMolecularMedicine,UniversityofOxford,JohnRadcliffeHospital,Oxford,UK.CorrespondencetoAdrianL.Harris,JohnRadcliffeHospital,Headington,Oxfordshire,OX39DSUnitedKingdom.E-mailaharris.lab@cancer.org.ukAbstractObjective—Thethrombolytictherapydrug,Reteplase,isadomaindeletionmutantof...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第4期LRP、TOPOⅡ及GSTπ在非小细胞肺癌中的表达及临床意义
...flungresistanceprotein,topoisomeraseⅡandglutathioneStransferaseπinnonsmallcelllungcancerWANGXia1WANGPeiyuan2WUShuhua1etal1DeptartmentofPathology,BinzhouMedicalUniversity,Binzhou256603;2DeptartmentofRadiology,BinzhouMedicalUniversity【Abstract】ObjectiveToinvestigatetheexpressionan...
医源资料库;在线期刊;滨州医学院学报;2009年第32卷第3期