SuppressionofOsteoclastogenesisbyN,N-Dimethyl-D-erythro-sphingosine:ASphingosineKinaseInhibition-IndependentAction
...l-D-erythro-sphingosine(DMS)competitivelyinhibitssphingosinekinase(SPHK)andhasbeenwidelyusedtoassesstheroleofSPHKduringcellularevents,includingmotility,proliferation,anddifferentiation.Inthepresentstudy,theeffectofDMSonthedifferentiationofbonemarrowmacrophages(BMMs)toosteoclastswasinvestigated.Whent...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期LiverXreceptorsand?regulatereninexpressioninvivo
1DukeUniversityMedicalCenter,Durham,NorthCarolina,USA.2BrighamandWomen’sHospitalandHarvardMedicalSchool,Boston,Massachusetts,USA.3KarolinskaInstitutet,Huddinge,Sweden.4CVTherapeuticsInc.,PaloAlto,California,USA.5ErasmusMC,Rotterdam,TheNetherlands.AbstractTherenin-angiotensin-aldosteronesystemcontr...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期TristetraprolinRegulatestheExpressionoftheHumanInducibleNitric-OxideSynthaseGene
DepartmentofPharmacology,JohannesGutenbergUniversity,Mainz,Germany(M.F.,K.L.,A.P.,T.H.,U.F.,H.K.)CentrodeInvestigacionesBioleicas,ConsejoSuperiordeInvestigacionesCienteicas,Madrid,Spain(F.R.-P.)AbstractTheexpressionofhumaninducibleNOsynthase(iNOS)isregulatedbothbytranscriptionalandpost-transcription...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第6期TheEffectofHydroxylamineonKATPChannelsinVascularSmoothMuscleandUnderlyingMechanisms
DepartmentsofPhysiology(G.T.,R.W.)andPharmacology(L.W.),CollegeofMedicine,UniversityofSaskatchewan,Saskatoon,CanadaAbstractHydroxylamine(HA)isaputativeintermediateintheconversionofL-argininetonitricoxide(NO).HAwasreportedtocausetherelaxationofprecontractedaortastrips;however,theionicmechanismsofHA-i...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第5期肝窦内皮细胞的结构及其功能
...明某些细胞外基质成分主要通过SEC内吞清除。透明质酸(HA)是由葡萄糖醛酸和乙酰葡萄糖胺构成的二糖单位聚合的基质多糖,是基质的主要构成成分,Fraser报道约88%放射标记的HA通过肝脏降解吸收。随后的研究表明SEC在HA的吸收...
医源资料库;在线期刊;中华现代外科学杂志;2005年第2卷第24期RegulationofD1DopamineReceptorTraffickingandSignalingbyCaveolin-1
【关键词】RegulationThereisaccumulatingevidencethatGprotein-coupledreceptorsignalingisregulatedbylocalizationinlipidraftmicrodomains.Inthisreport,wedeterminedthattheD1dopaminereceptor(D1R)islocalizedincaveolae,asubsetoflipidrafts,bysucrosegradientfractionationandconfocalmicroscopy.Throughcoimmu...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期大孔径速降解磷酸钙骨水泥的制备
...】磷酸钙骨水泥大孔降解Macroporous,quikdegradatablecalciumphosphatecement∥WUFei-yan,LIUXing-yan,GHENKe-ming,etal.LanzhouUniversity,Lanzhou730000,ChinaAbstract:[Objective]Toinvestigatetheeffectofaneffervescent-sucroseonthepropertiesofcalciumphosphatecement.[Method]Thesucrosepart...
医源资料库;在线期刊;中国矫形外科杂志;2008年第16卷第15期AroleforIgGimmunecomplexesduringinfectionwiththeintracellularpathogenLeishmania
...tibodiesinmediatinghostdefensetotheintracellularparasite,Leishmania.WeshowthatIgGnotonlyfailstoprovideprotectionagainstthisintracellularpathogen,butitactuallycontributestodiseaseprogression.TheJHstrainofBALB/cmice,whichlackIgGbecausetheyhaveatargeteddeletionintheIgheavychain(J)locus,weremoreresistan...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第5期UseofImmunoglobulinGAvidityAssaysforDifferentiationofPrimaryfromPreviousInfectionswithWestNileVirus
...CanadaEUROIMMUNAG,Luebeck,GermanyNationalMicrobiologyLaboratory,PublicHealthAgencyofCanada,Winnipeg,Manitoba,CanadaRobertKochInstitute,Berlin,GermanyABSTRACTSinceitsintroductionin1999,WestNilevirus(WNV)infectionshavespreadrapidlyacrosstheNorthAmericancontinent.DiagnosisofacuteWNVinfectionbydetection...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期纳米羟基磷灰石修复颌骨缺损的实验研究
...两种纳米羟基磷灰石进行家兔骨缺损修复。实验表明Nano-HA具有良好的生物相容性和降解性;为多中心成骨,参与骨的代谢,它的吸收速度与组织的长入速度一致;且750Nano-HA优于70Nano-HA。【关键词】纳米羟基磷灰石;骨缺损;骨生...
医源资料库;在线期刊;中华实用医药杂志;2011年第11卷第1期