Enhancedautoantigenexpressioninregeneratingmusclecellsinidiopathicinflammatorymyopathy
...nowntobeassociatedwithautoimmunemyositis,butnotintheirrelatednormaltissues,demonstratingthattumorcellsandundifferentiatedmyoblastsareantigenicallysimilar.Weproposethatincancer-associatedmyositis,anautoimmuneresponsedirectedagainstcancercross-reactswithregeneratingmusclecells,enablingafeed-forwardloo...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第4期TransmissionofBurkholderiacepaciaComplex:EvidenceforNewEpidemicClonesInfectingCysticFibrosisPatientsinItaly
...aples,ItalyABSTRACTToanalyzenationalprevalence,genomovardistribution,andepidemiologyoftheBurkholderiacepaciacomplexinItaly,225putativeB.cepaciacomplexisolateswereobtainedfrom225cysticfibrosis(CF)patientsattending18CFcenters.Thegenomovarstatusoftheseisolateswasdeterminedbyapolyphasicapproach,whichinc...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第10期SelectiveaccumulationofdifferentiatedCD8+Tcellsspecificforrespiratoryvirusesinthehumanlung
1DepartmentofPulmonology,AcademicMedicalCenter,UniversityofAmsterdam,1100DEAmsterdam,Netherlands2DepartmentofExperimentalImmunology,AcademicMedicalCenter,UniversityofAmsterdam,1100DEAmsterdam,Netherlands3DepartmentofNephrology,AcademicMedicalCenter,UniversityofAmsterdam,1100DEAmsterdam,NetherlandsTh...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第10期MUCACaGel-FormingMucinAccumulatinginGallstoneDiseaseIsOverproducedviaanEpidermalGrowthFactorReceptorPathwayintheHumanGallbladder
...detectedintheepitheliumandwithinmucusgelinthelumen.StudiesinprimaryculturesdemonstratedthatMUC5ACup-regulationinducedbythecombinationofTNF-withEGF-RligandswascompletelybluntedbyinhibitorsofEGF-Rtyrosinekinaseandmitogen-activatedprotein/extracellularsignal-relatedkinasekinase.Inconclusion,aninflammat...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期GestationalVitaminBDeficiencyLeadstoHomocysteine-AssociatedBrainApoptosisandAltersNeurobehavioralDevelopmentinRats
...stalkbetweenneuronsandastrocytes.Itmustbenoticed,however,thatithasbeennewlydemonstratedthatCBSissignificantlyexpressedinastrocytesthroughoutthemousebrain.46Inthehippocampusofdeficientrats,apoptosiswasfoundincellscontainingHcy,inlinewithanincreasedexpressionofp53,onemajorstepthroughwhichHcyhasbeensho...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第2期ShortPolybasicPeptideSequencesArePotentInhibitorsofPC5/6andPC7:UseofPositionalScanning-SyntheticPeptideCombinatorialLibrariesasaToolfort
...sbeenfarlessinvestigatedandstillremainspoorlyunderstood.AlthoughmanystudiesdemonstratedasignificantleveloffunctionalredundancyamongsomePCsandforsomesubstrates(Roebroeketal.,2004),distinctcleavagepatternsarealsoobserved.Forexample,PC2canprocesssubstrateswithaP1LysandmostotherPCsareapparentlylessstrin...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期CD4+CD25+regulatoryTcellsinhibitnaturalkillercellfunctionsinatransforminggrowthfactor––dependentmanner
...NSERM,U362,InstitutGustaveRoussy,94805Villejuif,France5INSERM,U517,FacultédeMédecine,UniversityofBurgundy,21079Dijon,France6Centred‘Immunologie,INSERM/CentreNationaldelaRechercheScientifiquedeMarseilleLuminy,13288Marseille,France7HospicesCivilsdeLyon,HpitalEdouardHériot,69003Lyon,France8CentreJ...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第8期HepatitisCVirusReplicationinTransfectedandSerum-InfectedCulturedHumanFetalHepatocytes
...ectableuntil4daysaftertransfection,buthighexpressionwaspresentatdays8and16,demonstratingafluctuatingpattern(notshown).CytoplasmicNS3wasdetectablebyimmunofluorescenceinclustersofcellstransfectedwithWTHCVRNA(Figure3).Figure2.DetectionofHCVnegative-strandRNAbystrand-specificinsituhybridizationandexpres...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第2期Lossofconstitutiveactivityofthegrowthhormonesecretagoguereceptorinfamilialshortstature
...alierUniversitaireHenri-Mondor,Créteil,France.2UniversitéParis12,FacultédeMédecine,Créteil,France.3AssistancePublique–H?pitauxdeParis,H?pitalArmand-Trousseau,Serviced’ExplorationsFonctionnellesEndocriniennes,Paris,France.4INSERM,U515,Paris,France.5UniversitéPierreetMarieCurie–Paris6,Pari...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期NovelStableCamptothecinDerivativesReplacingtheE-RingLactonebyaKetoneFunctionArePotentInhibitorsofTopoisomeraseIandPromisingAntitumorDrugs
...entopo1poisoning,formationofcleavablecomplexincells,andinductionofapoptosisdemonstratesthattopo1isthemainintracellulartargetofS38809.Invivo,S38809showedamarkedantitumoractivityagainstHCT116xenografts.98%asmeasuredbyanalyticalchiralchromatographyonaChiralpakAScolumninmethanol(flowrate:1ml/min).Thedru...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期