ShortPolybasicPeptideSequencesArePotentInhibitorsofPC5/6andPC7:UseofPositionalScanning-SyntheticPeptideCombinatorialLibrariesasaToolfort
...sbeenfarlessinvestigatedandstillremainspoorlyunderstood.AlthoughmanystudiesdemonstratedasignificantleveloffunctionalredundancyamongsomePCsandforsomesubstrates(Roebroeketal.,2004),distinctcleavagepatternsarealsoobserved.Forexample,PC2canprocesssubstrateswithaP1LysandmostotherPCsareapparentlylessstrin...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期CD4+CD25+regulatoryTcellsinhibitnaturalkillercellfunctionsinatransforminggrowthfactor––dependentmanner
...NSERM,U362,InstitutGustaveRoussy,94805Villejuif,France5INSERM,U517,FacultédeMédecine,UniversityofBurgundy,21079Dijon,France6Centred‘Immunologie,INSERM/CentreNationaldelaRechercheScientifiquedeMarseilleLuminy,13288Marseille,France7HospicesCivilsdeLyon,HpitalEdouardHériot,69003Lyon,France8CentreJ...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第8期HepatitisCVirusReplicationinTransfectedandSerum-InfectedCulturedHumanFetalHepatocytes
...ectableuntil4daysaftertransfection,buthighexpressionwaspresentatdays8and16,demonstratingafluctuatingpattern(notshown).CytoplasmicNS3wasdetectablebyimmunofluorescenceinclustersofcellstransfectedwithWTHCVRNA(Figure3).Figure2.DetectionofHCVnegative-strandRNAbystrand-specificinsituhybridizationandexpres...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第2期Lossofconstitutiveactivityofthegrowthhormonesecretagoguereceptorinfamilialshortstature
...alierUniversitaireHenri-Mondor,Créteil,France.2UniversitéParis12,FacultédeMédecine,Créteil,France.3AssistancePublique–H?pitauxdeParis,H?pitalArmand-Trousseau,Serviced’ExplorationsFonctionnellesEndocriniennes,Paris,France.4INSERM,U515,Paris,France.5UniversitéPierreetMarieCurie–Paris6,Pari...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期NovelStableCamptothecinDerivativesReplacingtheE-RingLactonebyaKetoneFunctionArePotentInhibitorsofTopoisomeraseIandPromisingAntitumorDrugs
...entopo1poisoning,formationofcleavablecomplexincells,andinductionofapoptosisdemonstratesthattopo1isthemainintracellulartargetofS38809.Invivo,S38809showedamarkedantitumoractivityagainstHCT116xenografts.98%asmeasuredbyanalyticalchiralchromatographyonaChiralpakAScolumninmethanol(flowrate:1ml/min).Thedru...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期Morethancolocalizingwithpolycystin-1,polycystin-Lisinthecentrosome
...somaljunctionthanwithE-cadherin.AsubpopulationofPCLwasalsopresentintheER,asdemonstratedbythecostainingwithconcanavalinA(Fig.2B,j-l).Fig.2.CommondistributionofPCLandPC1inconfluentinnermedullarycollectingduct(IMCD)cells.LocalizationofPC1andPCLwasdeterminedbyimmunofluorescencemicroscopyinpolarizedIMCDc...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期ModulationofpMitogen-ActivatedProteinKinaseCascadeandMetalloproteinaseActivityinDiaphragmMuscleinResponsetoFreeRadicalScavengerAdministrati
...erofadaptorproteinsinvolvedinavarietyofsignalingcascades.13,14Ithasalsobeendemonstratedthattheinteractionofdystroglycanwithlamininhasaninhibitoryeffectontheactivationoftheextracellularsignal-regulatedkinase(ERK)-mitogen-activatedprotein(MAP)kinasecascadeinresponsetothebindingofintegrinstolaminin.8Th...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第2期Subunit-StoichiometricEvidenceforKir6.2ChannelGating,ATPBinding,andBinding-GatingCoupling
...rstandsubunitstoichiometryfortheATP-dependentchannelgating,weconstructedtandem-multimericKir6.2channelsbyselectivedisruptionofthebindingorgatingmechanismincertainsubunits.StepwisedisruptionsofchannelgatingcausedgradedlossesinATPsensitivityandincreasesinbasalPopen,withnoeffectonmaximumATPinhibition.P...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期Identificationofhumanurinarytrefoilfactor1asanovelcalciumoxalatecrystalgrowthinhibitor
...time-of-flightMSandelectrosprayionization–quadrupole–time-of-flighttandemMSashumantrefoilfactor1(TFF1).Westernblotanalysisconfirmedthemassspectrometricproteinidentification.FunctionalstudiesofurinaryTFF1demonstratedthatitsinhibitorypotencywassimilartothatofnephrocalcin.Theinhibitoryactivityofuri...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第12期Megalinmediatesrenaluptakeofheavymetalmetallothioneincomplexes
...lableintheproximaltubuleforcompetitionwithMTtoactasprotectiveagents,ifwecandemonstratethatinhibitionobservedindirectmolecularinteractionsmatchesthewholeanimalpathophysiology.Ourresults,reportedhere,indicatethatmegalinbindsMTandimplicatesthehighlyconservedhingeorinterdomainregionofMT,centeredonalysin...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第9期